Pam | ENSRNOG00000033280 | NCBI 25508

Details for: Pam

Gene ID: 25508

Symbol: Pam

Ensembl ID: ENSRNOG00000033280

Description: peptidylglycine alpha-amidating monooxygenase

Associated with

Calcium ion binding
(GO:0005509)
Cell surface
(GO:0009986)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Condensed chromosome
(GO:0000793)
Copper ion binding
(GO:0005507)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid primary amide biosynthetic process
(GO:0062112)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
L-ascorbic acid binding
(GO:0031418)
Lactation
(GO:0007595)
Limb development
(GO:0060173)
Long-chain fatty acid metabolic process
(GO:0001676)
Lyase activity
(GO:0016829)
Maternal process involved in female pregnancy
(GO:0060135)
Mitotic chromosome condensation
(GO:0007076)
Neuronal cell body
(GO:0043025)
Ovulation cycle process
(GO:0022602)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
(GO:0016715)
Peptide amidation
(GO:0001519)
Peptide metabolic process
(GO:0006518)
Peptidylamidoglycolate lyase activity
(GO:0004598)
Peptidylglycine monooxygenase activity
(GO:0004504)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to copper ion
(GO:0046688)
Response to estradiol
(GO:0032355)
Response to glucocorticoid
(GO:0051384)
Response to hypoxia
(GO:0001666)
Response to ph
(GO:0009268)
Response to xenobiotic stimulus
(GO:0009410)
Response to zinc ion
(GO:0010043)
Secretory granule
(GO:0030141)
Toxin metabolic process
(GO:0009404)
Trans-golgi network
(GO:0005802)
Transport vesicle membrane
(GO:0030658)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

AMD_RAT

Genular Protein ID: 2189050143

Symbol: AMD_RAT

Name: N/A

UniProtKB Accession Codes:

P14925 P70710 Q64616 Q64668

Database IDs:

Citations:

PubMed ID: 2911604

Title: Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

PubMed ID: 2911604

DOI: 10.1073/pnas.86.2.735

PubMed ID: 1988445

Title: Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation.

PubMed ID: 1988445

DOI: 10.1016/s0021-9258(18)52352-8

PubMed ID: 2401356

Title: Isolation and functional expression of pituitary peptidylglycine alpha-amidating enzyme mRNA. A variant lacking the transmembrane domain.

PubMed ID: 2401356

DOI: 10.1016/0014-5793(90)81184-p

PubMed ID: 2337358

Title: Cloning and characterization of two alternatively spliced rat alpha-amidating enzyme cDNAs from rat medullary thyroid carcinoma.

PubMed ID: 2337358

DOI: 10.1016/0003-9861(90)90466-c

PubMed ID: 1740449

Title: Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM).

PubMed ID: 1740449

DOI: 10.1016/s0021-9258(19)50625-1

PubMed ID: 2211657

Title: Purification and characterization of functional recombinant alpha-amidating enzyme secreted from mammalian cells.

PubMed ID: 2211657

DOI: 10.1016/s0021-9258(18)38219-x

PubMed ID: 1448112

Title: The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains.

PubMed ID: 1448112

DOI: 10.1210/mend.6.10.1448112

PubMed ID: 9837933

Title: P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes.

PubMed ID: 9837933

DOI: 10.1074/jbc.273.50.33524

PubMed ID: 10079066

Title: N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides.

PubMed ID: 10079066

DOI: 10.1021/bi982255j

PubMed ID: 12369828

Title: Essential features of the catalytic core of peptidyl-alpha-hydroxyglycine alpha-amidating lyase.

PubMed ID: 12369828

DOI: 10.1021/bi0260280

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 10504734

Title: Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase.

PubMed ID: 10504734

DOI: 10.1038/13351

PubMed ID: 19604476

Title: Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme.

PubMed ID: 19604476

DOI: 10.1016/j.str.2009.05.008

Sequence Information:

Length: 976
Mass: 108675
Checksum: 7233021BEBEFD9B9
Sequence:

MAGRARSGLL LLLLGLLALQ SSCLAFRSPL SVFKRFKETT RSFSNECLGT IGPVTPLDAS 
DFALDIRMPG VTPKESDTYF CMSMRLPVDE EAFVIDFKPR ASMDTVHHML LFGCNMPSST 
GSYWFCDEGT CTDKANILYA WARNAPPTRL PKGVGFRVGG ETGSKYFVLQ VHYGDISAFR 
DNHKDCSGVS VHLTRVPQPL IAGMYLMMSV DTVIPPGEKV VNADISCQYK MYPMHVFAYR 
VHTHHLGKVV SGYRVRNGQW TLIGRQNPQL PQAFYPVEHP VDVTFGDILA ARCVFTGEGR 
TEATHIGGTS SDEMCNLYIM YYMEAKYALS FMTCTKNVAP DMFRTIPAEA NIPIPVKPDM 
VMMHGHHKEA ENKEKSALMQ QPKQGEEEVL EQGDFYSLLS KLLGEREDVH VHKYNPTEKT 
ESGSDLVAEI ANVVQKKDLG RSDAREGAEH EEWGNAILVR DRIHRFHQLE STLRPAESRA 
FSFQQPGEGP WEPEPSGDFH VEEELDWPGV YLLPGQVSGV ALDSKNNLVI FHRGDHVWDG 
NSFDSKFVYQ QRGLGPIEED TILVIDPNNA EILQSSGKNL FYLPHGLSID TDGNYWVTDV 
ALHQVFKLDP HSKEGPLLIL GRSMQPGSDQ NHFCQPTDVA VEPSTGAVFV SDGYCNSRIV 
QFSPSGKFVT QWGEESSGSS PRPGQFSVPH SLALVPHLDQ LCVADRENGR IQCFKTDTKE 
FVREIKHASF GRNVFAISYI PGFLFAVNGK PYFGDQEPVQ GFVMNFSSGE IIDVFKPVRK 
HFDMPHDIVA SEDGTVYIGD AHTNTVWKFT LTEKMEHRSV KKAGIEVQEI KEAEAVVEPK 
VENKPTSSEL QKMQEKQKLS TEPGSGVSVV LITTLLVIPV LVLLAIVMFI RWKKSRAFGD 
HDRKLESSSG RVLGRFRGKG SGGLNLGNFF ASRKGYSRKG FDRVSTEGSD QEKDEDDGTE 
SEEEYSAPLP KPAPSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pam

Associated with

Other Information

Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium. PubMed ID: 2911604

Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation. PubMed ID: 1988445

Isolation and functional expression of pituitary peptidylglycine alpha-amidating enzyme mRNA. A variant lacking the transmembrane domain. PubMed ID: 2401356

Cloning and characterization of two alternatively spliced rat alpha-amidating enzyme cDNAs from rat medullary thyroid carcinoma. PubMed ID: 2337358

Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM). PubMed ID: 1740449

Purification and characterization of functional recombinant alpha-amidating enzyme secreted from mammalian cells. PubMed ID: 2211657

The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains. PubMed ID: 1448112

P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. PubMed ID: 9837933

N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides. PubMed ID: 10079066

Essential features of the catalytic core of peptidyl-alpha-hydroxyglycine alpha-amidating lyase. PubMed ID: 12369828

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase. PubMed ID: 10504734

Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme. PubMed ID: 19604476