Details for: Pou1f1

Gene ID: 25517

Symbol: Pou1f1

Ensembl ID: ENSRNOG00000000715

Description: POU class 1 homeobox 1

Associated with

  • Adenohypophysis development
    (GO:0021984)
  • B cell differentiation
    (GO:0030183)
  • Cell fate specification
    (GO:0001708)
  • Cell population proliferation
    (GO:0008283)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cytosol
    (GO:0005829)
  • Determination of adult lifespan
    (GO:0008340)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Inositol trisphosphate biosynthetic process
    (GO:0032959)
  • Lncrna binding
    (GO:0106222)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of inositol trisphosphate biosynthetic process
    (GO:0032962)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatotropin secreting cell development
    (GO:0060133)
  • Somatotropin secreting cell differentiation
    (GO:0060126)

Other Information

Genular Protein ID: 2733609679

Symbol: PIT1_RAT

Name: Pituitary-specific positive transcription factor 1

UniProtKB Accession Codes:

P10037 Q63431

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 CDD 1 CORUM 1 CTD 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 GO 31 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2902927

Title: The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein.

PubMed ID: 2902927

DOI: 10.1016/0092-8674(88)90037-2

PubMed ID: 2902928

Title: A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.

PubMed ID: 2902928

DOI: 10.1016/0092-8674(88)90038-4

PubMed ID: 1600947

Title: Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.

PubMed ID: 1600947

DOI: 10.1002/j.1460-2075.1992.tb05285.x

PubMed ID: 1569967

Title: Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.

PubMed ID: 1569967

DOI: 10.1210/mend.6.2.1569967

PubMed ID: 1561093

Title: An alternatively spliced Pit-1 isoform altered in its ability to trans-activate.

PubMed ID: 1561093

DOI: 10.1093/nar/20.6.1355

PubMed ID: 9009203

Title: Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.

PubMed ID: 9009203

DOI: 10.1101/gad.11.2.198

Sequence Information:

  • Length: 291
  • Mass: 32903
  • Checksum: 2651876B2F7668A1
  • Sequence:
    • MSCQPFTSAD TFIPLNSDAS AALPLRMHHS AAEGLPASNH ATNVMSTATG LHYSVPSCHY 
GNQPSTYGVM AGTLTPCLYK FPDHTLSHGF PPLHQPLLAE DPTASEFKQE LRRKSKLVEE 
PIDMDSPEIR ELEQFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF 
KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEHSKPS 
SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R

Genular Protein ID: 1066748904

Symbol: A6K4W6_RAT

Name: N/A

UniProtKB Accession Codes:

A6K4W6

Database IDs:

ARBA 7 CDD 1 CTD 1 EMBL 2 GO 3 Gene3D 2 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RGD 2 RefSeq 1 RuleBase 2 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 317
  • Mass: 35770
  • Checksum: F217B4F2307D7940
  • Sequence:
    • MSCQPFTSAD TFIPLNSDAS AALPLRMHHS AAEGLPASNH ATNVMSTVPS ILSLIQTPKC 
LHTYFSMTTM GNTATGLHYS VPSCHYGNQP STYGVMAGTL TPCLYKFPDH TLSHGFPPLH 
QPLLAEDPTA SEFKQELRRK SKLVEEPIDM DSPEIRELEQ FANEFKVRRI KLGYTQTNVG 
EALAAVHGSE FSQTTICRFE NLQLSFKNAC KLKAILSKWL EEAEQVGALY NEKVGANERK 
RKRRTTISIA AKDALERHFG EHSKPSSQEI MRMAEELNLE KEVVRVWFCN RRQREKRVKT 
SLNQSLFSIS KEHLECR

Genular Protein ID: 2564976487

Symbol: Q6P7Q8_RAT

Name: N/A

UniProtKB Accession Codes:

Q6P7Q8

Database IDs:

ARBA 7 AlphaFoldDB 1 CDD 1 CTD 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 Pfam 2 RGD 2 RefSeq 1 RuleBase 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 291
  • Mass: 32930
  • Checksum: 265E745B2F724291
  • Sequence:
    • MSCQPFTSAD TFIPLNSDAS AALPLRMHHN AAEGLPASNH ATNVMSTATG LHYSVPSCHY 
GNQPSTYGVM AGTLTPCLYK FPDHTLSHGF PPLHQPLLAE DPTASEFKQE LRRKSKLVEE 
PIDMDSPEIR ELEQFANEFK VRRIKLGYTQ TNVGEALAAV HGSEFSQTTI CRFENLQLSF 
KNACKLKAIL SKWLEEAEQV GALYNEKVGA NERKRKRRTT ISIAAKDALE RHFGEHSKPS 
SQEIMRMAEE LNLEKEVVRV WFCNRRQREK RVKTSLNQSL FSISKEHLEC R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.