Rab3a | ENSRNOG00000019433 | NCBI 25531

Details for: Rab3a

Gene ID: 25531

Symbol: Rab3a

Ensembl ID: ENSRNOG00000019433

Description: RAB3A, member RAS oncogene family

Associated with

Acetylcholine neurotransmitter release cycle
(R-RNO-264642)
Dopamine neurotransmitter release cycle
(R-RNO-212676)
Gaba synthesis, release, reuptake and degradation
(R-RNO-888590)
Glutamate neurotransmitter release cycle
(R-RNO-210500)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Neuronal system
(R-RNO-112316)
Neurotransmitter release cycle
(R-RNO-112310)
Neutrophil degranulation
(R-RNO-6798695)
Norepinephrine neurotransmitter release cycle
(R-RNO-181430)
Post-translational protein modification
(R-RNO-597592)
Rab gefs exchange gtp for gdp on rabs
(R-RNO-8876198)
Rab geranylgeranylation
(R-RNO-8873719)
Rab regulation of trafficking
(R-RNO-9007101)
Serotonin neurotransmitter release cycle
(R-RNO-181429)
Transmission across chemical synapses
(R-RNO-112315)
Vesicle-mediated transport
(R-RNO-5653656)
Acrosomal vesicle
(GO:0001669)
Acrosomal vesicle exocytosis
(GO:0060478)
Atpase activator activity
(GO:0001671)
Atpase binding
(GO:0051117)
Axon
(GO:0030424)
Axonogenesis
(GO:0007409)
Calcium-ion regulated exocytosis
(GO:0017156)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Establishment of localization in cell
(GO:0051649)
Evoked neurotransmitter secretion
(GO:0061670)
Exocytosis
(GO:0006887)
Gdp-dissociation inhibitor binding
(GO:0051021)
Gtp-dependent protein binding
(GO:0030742)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Insulin secretion
(GO:0030073)
Intracellular protein transport
(GO:0006886)
Lung development
(GO:0030324)
Lysosome
(GO:0005764)
Lysosome localization
(GO:0032418)
Maintenance of presynaptic active zone structure
(GO:0048790)
Mitochondrion organization
(GO:0007005)
Myosin v binding
(GO:0031489)
Neuromuscular synaptic transmission
(GO:0007274)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Plasma membrane repair
(GO:0001778)
Positive regulation of regulated secretory pathway
(GO:1903307)
Post-embryonic development
(GO:0009791)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Presynaptic active zone
(GO:0048786)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein secretion
(GO:0009306)
Rab protein signal transduction
(GO:0032482)
Regulated exocytosis
(GO:0045055)
Regulation of dopamine secretion
(GO:0014059)
Regulation of exocytosis
(GO:0017157)
Regulation of plasma membrane repair
(GO:1905684)
Regulation of presynaptic dense core granule exocytosis
(GO:0099161)
Regulation of short-term neuronal synaptic plasticity
(GO:0048172)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Regulation of synaptic vesicle fusion to presynaptic active zone membrane
(GO:0031630)
Regulation of synaptic vesicle priming
(GO:0010807)
Respiratory system process
(GO:0003016)
Response to electrical stimulus
(GO:0051602)
Secretory granule
(GO:0030141)
Sensory perception of touch
(GO:0050975)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle clustering
(GO:0097091)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle maturation
(GO:0016188)
Synaptic vesicle membrane
(GO:0030672)
Synaptic vesicle recycling
(GO:0036465)
Synaptic vesicle transport
(GO:0048489)
Terminal bouton
(GO:0043195)
Vesicle docking involved in exocytosis
(GO:0006904)

Other Information

Proteins

Ras-related protein Rab-3A

Genular Protein ID: 79955896

Symbol: RAB3A_RAT

Name: Ras-related protein Rab-3A

UniProtKB Accession Codes:

P63012 P05713

Database IDs:

Citations:

PubMed ID: 3317403

Title: Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

PubMed ID: 3317403

DOI: 10.1073/pnas.84.23.8210

PubMed ID: 3344209

Title: Complete coding sequences of the ras related rab 3 and 4 cDNAs.

PubMed ID: 3344209

DOI: 10.1093/nar/16.3.1204

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18407218

Title: Role of the Rab3A GTPase in regulated secretion from neuroendocrine cells.

PubMed ID: 18407218

DOI: 10.1016/1043-2760(94)p3201-h

PubMed ID: 7532276

Title: Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A.

PubMed ID: 7532276

DOI: 10.1128/mcb.15.3.1137

PubMed ID: 10748113

Title: The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins.

PubMed ID: 10748113

DOI: 10.1074/jbc.m909008199

PubMed ID: 17311845

Title: Differential dynamics of Rab3A and Rab27A on secretory granules.

PubMed ID: 17311845

DOI: 10.1242/jcs.03406

PubMed ID: 17149709

Title: Visualization of Rab3A dissociation during exocytosis: a study by total internal reflection microscopy.

PubMed ID: 17149709

DOI: 10.1002/jcp.20938

PubMed ID: 21689256

Title: Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.

PubMed ID: 21689256

DOI: 10.1111/j.1600-0854.2011.01237.x

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 28057568

Title: Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism.

PubMed ID: 28057568

DOI: 10.1016/j.ijbiomac.2016.12.074

PubMed ID: 10025402

Title: Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A.

PubMed ID: 10025402

DOI: 10.1016/s0092-8674(00)80549-8

PubMed ID: 10196122

Title: Structural basis of activation and GTP hydrolysis in rab proteins.

PubMed ID: 10196122

DOI: 10.1016/s0969-2126(99)80054-9

Sequence Information:

Length: 220
Mass: 24970
Checksum: 1A3E9F8C9D09EB40
Sequence:

MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA FVSTVGIDFK 
VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL MYDITNEESF NAVQDWSTQI 
KTYSWDNAQV LLVGNKCDME DERVVSSERG RQLADHLGFE FFEASAKDNI NVKQTFERLV 
DVICEKMSES LDTADPAVTG AKQGPQLTDQ QAPPHQDCAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rab3a

Associated with

Other Information

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. PubMed ID: 3317403

Complete coding sequences of the ras related rab 3 and 4 cDNAs. PubMed ID: 3344209

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of the Rab3A GTPase in regulated secretion from neuroendocrine cells. PubMed ID: 18407218

Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. PubMed ID: 7532276

The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. PubMed ID: 10748113

Differential dynamics of Rab3A and Rab27A on secretory granules. PubMed ID: 17311845

Visualization of Rab3A dissociation during exocytosis: a study by total internal reflection microscopy. PubMed ID: 17149709

Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1. PubMed ID: 21689256

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Localization of Rab3A-binding site on C2A domain of synaptotagmin I to reveal its regulatory mechanism. PubMed ID: 28057568

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. PubMed ID: 10025402

Structural basis of activation and GTP hydrolysis in rab proteins. PubMed ID: 10196122