Rabggtb | ENSRNOG00000009992 | NCBI 25533

Details for: Rabggtb

Gene ID: 25533

Symbol: Rabggtb

Ensembl ID: ENSRNOG00000009992

Description: Rab geranylgeranyltransferase subunit beta

Associated with

Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Metabolism of proteins
(R-RNO-392499)
Post-translational protein modification
(R-RNO-597592)
Rab geranylgeranylation
(R-RNO-8873719)
Rna polymerase ii transcription
(R-RNO-73857)
Tp53 regulates transcription of cell death genes
(R-RNO-5633008)
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
(R-RNO-6803205)
Transcriptional regulation by tp53
(R-RNO-3700989)
Isoprenoid binding
(GO:0019840)
Metal ion binding
(GO:0046872)
Protein binding
(GO:0005515)
Protein geranylgeranylation
(GO:0018344)
Rab-protein geranylgeranyltransferase complex
(GO:0005968)
Rab geranylgeranyltransferase activity
(GO:0004663)
Small gtpase binding
(GO:0031267)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Geranylgeranyl transferase type-2 subunit beta
A6HWN7_RAT

Genular Protein ID: 1008564701

Symbol: PGTB2_RAT

Name: Geranylgeranyl transferase type-2 subunit beta

UniProtKB Accession Codes:

Q08603

Database IDs:

Citations:

PubMed ID: 8505342

Title: cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.

PubMed ID: 8505342

DOI: 10.1016/s0021-9258(19)50329-5

PubMed ID: 11675392

Title: Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

PubMed ID: 11675392

DOI: 10.1074/jbc.m108241200

PubMed ID: 10745007

Title: Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.

PubMed ID: 10745007

DOI: 10.1016/s0969-2126(00)00102-7

PubMed ID: 12620235

Title: Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

PubMed ID: 12620235

DOI: 10.1016/s1097-2765(03)00044-3

PubMed ID: 18399557

Title: Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex.

PubMed ID: 18399557

DOI: 10.1002/anie.200705795

PubMed ID: 18756270

Title: Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.

PubMed ID: 18756270

DOI: 10.1038/emboj.2008.164

PubMed ID: 19894725

Title: Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors.

PubMed ID: 19894725

DOI: 10.1021/jm901117d

PubMed ID: 22480322

Title: Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.

PubMed ID: 22480322

DOI: 10.1021/ja211305j

PubMed ID: 22963166

Title: Development of selective, potent RabGGTase inhibitors.

PubMed ID: 22963166

DOI: 10.1021/jm300624s

Sequence Information:

Length: 331
Mass: 36856
Checksum: 4B12DEC0245979D6
Sequence:

MGTQQKDVTI KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGV YWGLTVMDLM 
GQLHRMNKEE ILVFIKSCQH ECGGVSASIG HDPHLLYTLS AVQILTLYDS IHVINVDKVV 
AYVQSLQKED GSFAGDIWGE IDTRFSFCAV ATLALLGKLD AINVEKAIEF VLSCMNFDGG 
FGCRPGSESH AGQIYCCTGF LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC 
YSWWVLASLK IIGRLHWIDR EKLRSFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL 
LGEEQIKPVS PVFCMPEEVL QRVNVQPELV S

Genular Protein ID: 2702465693

Symbol: A6HWN7_RAT

Name: N/A

UniProtKB Accession Codes:

A6HWN7 Q68G48

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 331
Mass: 36842
Checksum: 4B12DEC024583CD6
Sequence:

MGTQQKDVTI KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGV YWGLTVMDLM 
GQLHRMNKEE ILVFIKSCQH ECGGVSASIG HDPHLLYTLS AVQILTLYDS IHVINVDKVV 
AYVQSLQKED GSFAGDIWGE IDTRFSFCAV ATLALLGKLD AINVEKAIEF VLSCMNFDGG 
FGCRPGSESH AGQIYCCTGF LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC 
YSWWVLASLK IIGRLHWIDR EKLRSFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL 
LGEEQIKPVS PVFCMPEDVL QRVNVQPELV S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rabggtb

Associated with

Other Information

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. PubMed ID: 8505342

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1. PubMed ID: 11675392

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. PubMed ID: 10745007

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. PubMed ID: 12620235

Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. PubMed ID: 18399557

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. PubMed ID: 18756270

Design, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitors. PubMed ID: 19894725

Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. PubMed ID: 22480322

Development of selective, potent RabGGTase inhibitors. PubMed ID: 22963166

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822