Details for: Snai2

Gene ID: 25554

Symbol: Snai2

Ensembl ID: ENSRNOG00000047699

Description: snail family transcriptional repressor 2

Associated with

  • Cartilage morphogenesis
    (GO:0060536)
  • Cell migration involved in endocardial cushion formation
    (GO:0003273)
  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to ionizing radiation
    (GO:0071479)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Cytoplasm
    (GO:0005737)
  • Desmosome disassembly
    (GO:0035921)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • Endothelial cell migration
    (GO:0043542)
  • Epithelial cell migration
    (GO:0010631)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • Epithelium development
    (GO:0060429)
  • Hematopoietic stem cell proliferation
    (GO:0071425)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Negative regulation of anoikis
    (GO:2000811)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell adhesion involved in substrate-bound cell migration
    (GO:0006933)
  • Negative regulation of cell adhesion mediated by integrin
    (GO:0033629)
  • Negative regulation of chondrocyte differentiation
    (GO:0032331)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of hematopoietic stem cell proliferation
    (GO:1902034)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Negative regulation of keratinocyte proliferation
    (GO:0010839)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of vitamin d biosynthetic process
    (GO:0010957)
  • Negative regulation of vitamin d receptor signaling pathway
    (GO:0070563)
  • Neural crest cell development
    (GO:0014032)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Osteoblast differentiation
    (GO:0001649)
  • Pigmentation
    (GO:0043473)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Regulation of bicellular tight junction assembly
    (GO:2000810)
  • Regulation of branching involved in salivary gland morphogenesis
    (GO:0060693)
  • Regulation of chemokine production
    (GO:0032642)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Response to radiation
    (GO:0009314)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Substrate-dependent cell migration
    (GO:0006929)
  • White fat cell differentiation
    (GO:0050872)

Other Information

Genular Protein ID: 2744325771

Symbol: SNAI2_RAT

Name: Zinc finger protein SNAI2

UniProtKB Accession Codes:

O08954 Q8R482

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CTD 1 EMBL 2 Ensembl 4 GO 56 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UniProtKB 1 eggNOG 1

Citations:

PubMed ID: 9182671

Title: The zinc-finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.

PubMed ID: 9182671

DOI: 10.1083/jcb.137.6.1403

PubMed ID: 16924233

Title: Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug.

PubMed ID: 16924233

DOI: 10.1038/sj.onc.1209902

Sequence Information:

  • Length: 268
  • Mass: 29936
  • Checksum: 92B6325E54CEFD4B
  • Sequence:
    • MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLCESYPMP VIPKPEILTS GAYSPITVWT 
SAVPFHSPLP SGLSPLTGYS SSLGRVSPLP SSDTSSKDHS GSESPISDEE ERLQPKLSDP 
HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH CDAQARKSFS CKYCDKEYVS LGALKMHIRT 
HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK 
YQCKNCSKTF SRMSLLHKHE ESGCCVAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.