Chrna4 | ENSRNOG00000011202 | NCBI 25590

Details for: Chrna4

Gene ID: 25590

Symbol: Chrna4

Ensembl ID: ENSRNOG00000011202

Description: cholinergic receptor nicotinic alpha 4 subunit

Associated with

Acetylcholine binding and downstream events
(R-RNO-181431)
Highly calcium permeable nicotinic acetylcholine receptors
(R-RNO-629597)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-RNO-629594)
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
(R-RNO-629587)
Neuronal system
(R-RNO-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-RNO-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-RNO-622327)
Presynaptic nicotinic acetylcholine receptors
(R-RNO-622323)
Transmission across chemical synapses
(R-RNO-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
B cell activation
(GO:0042113)
Behavioral response to nicotine
(GO:0035095)
Calcium ion transport
(GO:0006816)
Cholinergic synapse
(GO:0098981)
Cognition
(GO:0050890)
Dendrite
(GO:0030425)
Dna repair
(GO:0006281)
Dopaminergic synapse
(GO:0098691)
Excitatory postsynaptic potential
(GO:0060079)
Exploration behavior
(GO:0035640)
External side of plasma membrane
(GO:0009897)
Heterocyclic compound binding
(GO:1901363)
Inhibitory postsynaptic potential
(GO:0060080)
Locomotory behavior
(GO:0007626)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Nervous system process
(GO:0050877)
Neuronal action potential
(GO:0019228)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Quaternary ammonium group binding
(GO:0050997)
Regulation of dopamine secretion
(GO:0014059)
Regulation of membrane potential
(GO:0042391)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to acetylcholine
(GO:1905144)
Response to hypoxia
(GO:0001666)
Response to nicotine
(GO:0035094)
Response to oxidative stress
(GO:0006979)
Sensory perception of pain
(GO:0019233)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)
Transmembrane signaling receptor activity
(GO:0004888)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Neuronal acetylcholine receptor subunit alpha-4

Genular Protein ID: 3101769275

Symbol: ACHA4_RAT

Name: Neuronal acetylcholine receptor subunit alpha-4

UniProtKB Accession Codes:

P09483 O35769

Database IDs:

Citations:

PubMed ID: 3829125

Title: Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system.

PubMed ID: 3829125

DOI: 10.1016/0092-8674(87)90705-7

PubMed ID: 3609304

Title: Neuronal nicotinic acetylcholine receptor beta-subunit is coded for by the cDNA clone alpha 4.

PubMed ID: 3609304

DOI: 10.1016/0014-5793(87)80272-7

PubMed ID: 15929983

Title: Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor.

PubMed ID: 15929983

DOI: 10.1074/jbc.m504229200

PubMed ID: 22593584

Title: A highly conserved cytoplasmic cysteine residue in the alpha4 nicotinic acetylcholine receptor is palmitoylated and regulates protein expression.

PubMed ID: 22593584

DOI: 10.1074/jbc.m111.328294

PubMed ID: 22751014

Title: alpha6 nAChR subunit residues that confer alpha-conotoxin BuIA selectivity.

PubMed ID: 22751014

DOI: 10.1096/fj.12-204487

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 630
Mass: 70193
Checksum: 1DFFC9E1378E5417
Sequence:

MANSGTGAPP PLLLLPLLLL LGTGLLPASS HIETRAHAEE RLLKRLFSGY NKWSRPVANI 
SDVVLVRFGL SIAQLIDVDE KNQMMTTNVW VKQEWHDYKL RWDPGDYENV TSIRIPSELI 
WRPDIVLYNN ADGDFAVTHL TKAHLFYDGR VQWTPPAIYK SSCSIDVTFF PFDQQNCTMK 
FGSWTYDKAK IDLVSMHSRV DQLDFWESGE WVIVDAVGTY NTRKYECCAE IYPDITYAFI 
IRRLPLFYTI NLIIPCLLIS CLTVLVFYLP SECGEKVTLC ISVLLSLTVF LLLITEIIPS 
PTSLVIPLIG EYLLFTMIFV TLSIVITVFV LNVHHRSPRT HTMPAWVRRV FLDIVPRLLF 
MKRPSVVKDN CRRLIESMHK MANAPRFWPE PVGEPGILSD ICNQGLSPAP TFCNPTDTAV 
ETQPTCRSPP LEVPDLKTSE VEKASPCPSP GSCPPPKSSS GAPMLIKARS LSVQHVPSSQ 
EAAEDGIRCR SRSIQYCVSQ DGAASLADSK PTSSPTSLKA RPSQLPVSDQ ASPCKCTCKE 
PSPVSPVTVL KAGGTKAPPQ HLPLSPALTR AVEGVQYIAD HLKAEDTDFS VKEDWKYVAM 
VIDRIFLWMF IIVCLLGTVG LFLPPWLAAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrna4

Associated with

Other Information

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system. PubMed ID: 3829125

Neuronal nicotinic acetylcholine receptor beta-subunit is coded for by the cDNA clone alpha 4. PubMed ID: 3609304

Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. PubMed ID: 15929983

A highly conserved cytoplasmic cysteine residue in the alpha4 nicotinic acetylcholine receptor is palmitoylated and regulates protein expression. PubMed ID: 22593584

alpha6 nAChR subunit residues that confer alpha-conotoxin BuIA selectivity. PubMed ID: 22751014