Parp1 | ENSRNOG00000003084 | NCBI 25591

Details for: Parp1

Gene ID: 25591

Symbol: Parp1

Ensembl ID: ENSRNOG00000003084

Description: poly (ADP-ribose) polymerase 1

Associated with

Base excision repair
(R-RNO-73884)
Dna damage recognition in gg-ner
(R-RNO-5696394)
Dna double-strand break repair
(R-RNO-5693532)
Downregulation of smad2/3:smad4 transcriptional activity
(R-RNO-2173795)
Dual incision in gg-ner
(R-RNO-5696400)
Formation of incision complex in gg-ner
(R-RNO-5696395)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Global genome nucleotide excision repair (gg-ner)
(R-RNO-5696399)
Hdr through mmej (alt-nhej)
(R-RNO-5685939)
Homology directed repair
(R-RNO-5693538)
Metabolism of proteins
(R-RNO-392499)
Nucleotide excision repair
(R-RNO-5696398)
Polb-dependent long patch base excision repair
(R-RNO-110362)
Post-translational protein modification
(R-RNO-597592)
Resolution of abasic sites (ap sites)
(R-RNO-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-RNO-110373)
Rna polymerase ii transcription
(R-RNO-73857)
Signaling by tgf-beta receptor complex
(R-RNO-170834)
Signaling by tgfb family members
(R-RNO-9006936)
Signal transduction
(R-RNO-162582)
Sumo e3 ligases sumoylate target proteins
(R-RNO-3108232)
Sumoylation
(R-RNO-2990846)
Sumoylation of dna damage response and repair proteins
(R-RNO-3108214)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-RNO-2173793)
Apoptotic process
(GO:0006915)
Base-excision repair
(GO:0006284)
Behavioral response to cocaine
(GO:0048148)
Carbohydrate biosynthetic process
(GO:0016051)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to uv
(GO:0034644)
Chromatin binding
(GO:0003682)
Damaged dna binding
(GO:0003684)
Decidualization
(GO:0046697)
Dna adp-ribosylation
(GO:0030592)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna metabolic process
(GO:0006259)
Dna repair
(GO:0006281)
Double-strand break repair
(GO:0006302)
Enzyme binding
(GO:0019899)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Mitochondrial dna metabolic process
(GO:0032042)
Mitochondrial dna repair
(GO:0043504)
Mitochondrion organization
(GO:0007005)
Nad+-histone h2be35 glutamate adp-ribosyltransferase activity
(GO:0140822)
Nad+-histone h2bs6 serine adp-ribosyltransferase activity
(GO:0140816)
Nad+-histone h3s10 serine adp-ribosyltransferase activity
(GO:0140817)
Nad+- protein-aspartate adp-ribosyltransferase activity
(GO:0140806)
Nad+-protein-glutamate adp-ribosyltransferase activity
(GO:0140807)
Nad+-protein-histidine adp-ribosyltransferase activity
(GO:0140815)
Nad+-protein-serine adp-ribosyltransferase activity
(GO:0140805)
Nad+-protein-tyrosine adp-ribosyltransferase activity
(GO:0140808)
Nad+-protein adp-ribosyltransferase activity
(GO:1990404)
Nad+ adp-ribosyltransferase activity
(GO:0003950)
Nad binding
(GO:0051287)
Nad dna adp-ribosyltransferase activity
(GO:0140294)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transcription elongation by rna polymerase ii
(GO:0034244)
Nuclear estrogen receptor binding
(GO:0030331)
Nucleosome binding
(GO:0031491)
Nucleotidyltransferase activity
(GO:0016779)
Pentosyltransferase activity
(GO:0016763)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of dna-templated transcription, elongation
(GO:0032786)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein modification process
(GO:0036211)
R-smad binding
(GO:0070412)
Regulation of circadian sleep/wake cycle, non-rem sleep
(GO:0045188)
Regulation of growth rate
(GO:0040009)
Regulation of protein localization
(GO:0032880)
Response to gamma radiation
(GO:0010332)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Telomere maintenance
(GO:0000723)
Transcription regulator activator activity
(GO:0140537)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin protein ligase binding
(GO:0031625)
Voluntary musculoskeletal movement
(GO:0050882)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Poly [ADP-ribose] polymerase 1

Genular Protein ID: 3874788455

Symbol: PARP1_RAT

Name: Poly [ADP-ribose] polymerase 1

UniProtKB Accession Codes:

P27008 O35937

Database IDs:

Citations:

PubMed ID: 9385436

Title: Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly (ADP-ribose) polymerase.

PubMed ID: 9385436

DOI: 10.1080/15216549700204571

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1601134

Title: Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase.

PubMed ID: 1601134

DOI: 10.1016/0014-5793(92)80457-r

PubMed ID: 2508731

Title: Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle.

PubMed ID: 2508731

DOI: 10.1139/o89-097

PubMed ID: 25625556

Title: The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1.

PubMed ID: 25625556

DOI: 10.1111/bph.13091

PubMed ID: 21967661

Title: Structural studies of the PARP-1 BRCT domain.

PubMed ID: 21967661

DOI: 10.1186/1472-6807-11-37

Sequence Information:

Length: 1014
Mass: 112660
Checksum: BE1B6F2B29B887ED
Sequence:

MAEATERLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV 
GHSIRQPDTE VDGFSELRWD DQQKVKKTAE AGGVAGKGQH GGGGKAEKTL GDFAAEYAKS 
NRSTCKGCME KIEKGQMRLS KKMLDPEKPQ LGMIDRWYHP TCFVKNRDEL GFRPEYSASQ 
LKGFSLLSAE DKEALKKQLP AVKSEGKRKC DEVDGIDEVA KKKSKKGKDK ESSKLEKALK 
AQNELVWNIK DELKKACSTN DLKELLIFNQ QQVPSGESAI LDRVADGMAF GALLPCKECS 
GQLVFKSDAY YCTGDVTAWT KCMVKTQNPS RKEWVTPKEF REISYLKKLK IKKQDRLFPP 
ESSAPAPPAP PVSITSAPTA VNSSAPADKP LSNMKILTLG KLSQNKDEAK AMIEKLGGKL 
TGSANKASLC ISTKKEVEKM SKKMEEVKAA NVRVVCEDFL QDVSASAKSL QELLSAHSLS 
SWGAEVKVEP GEVVVPKGKS AAPSKKSKGA VKEEGVNKSE KRMKLTLKGG AAVDPDSGLE 
HSAHVLEKGG KVFSATLGLV DIVKGTNSYY KLQLLESDKE SRYWIFRSWG RVGTVIGSNK 
LEQMPSKEDA VEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE AVKKLAVKPG 
TKSKLPKPVQ ELVGMIFDVE SMKKALVEYE IDLQKMPLGK LSRRQIQAAY SILSEVQQAV 
SQGSSESQIL DLSNRFYTLI PHDFGMKKPP LLNNTDSVQA KVEMLDNLLD IEVAYSLLRG 
GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEVIRKYVKN THATTHNAYD LEVIDIFKIE 
REGESQRYKP FRQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM 
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTAPDPSA 
SITLDGVEVP LGTGIPSGVN DTCLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Parp1

Associated with

Other Information

Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly (ADP-ribose) polymerase. PubMed ID: 9385436

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase. PubMed ID: 1601134

Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle. PubMed ID: 2508731

The orphan receptor NOR1 participates in isoprenaline-induced cardiac hypertrophy by regulating PARP-1. PubMed ID: 25625556