Details for: Cd74

Gene ID: 25599

Symbol: Cd74

Ensembl ID: ENSRNOG00000018735

Description: CD74 molecule

Associated with

  • Adaptive immune system
    (R-RNO-1280218)
  • Cell surface interactions at the vascular wall
    (R-RNO-202733)
  • Hemostasis
    (R-RNO-109582)
  • Immune system
    (R-RNO-168256)
  • Mhc class ii antigen presentation
    (R-RNO-2132295)
  • Amyloid-beta binding
    (GO:0001540)
  • Antigen processing and presentation
    (GO:0019882)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ii
    (GO:0019886)
  • Canonical nf-kappab signal transduction
    (GO:0007249)
  • Cd4 receptor binding
    (GO:0042609)
  • Cell surface
    (GO:0009986)
  • Chaperone cofactor-dependent protein refolding
    (GO:0051085)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine binding
    (GO:0019955)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytoplasm
    (GO:0005737)
  • Defense response
    (GO:0006952)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Immunoglobulin mediated immune response
    (GO:0016064)
  • Intracellular protein transport
    (GO:0006886)
  • Late endosome
    (GO:0005770)
  • Lysosome
    (GO:0005764)
  • Macrophage migration inhibitory factor binding
    (GO:0035718)
  • Macrophage migration inhibitory factor receptor complex
    (GO:0035692)
  • Macrophage migration inhibitory factor signaling pathway
    (GO:0035691)
  • Membrane
    (GO:0016020)
  • Mhc class ii protein binding
    (GO:0042289)
  • Mhc class ii protein binding, via antigen binding groove
    (GO:0042658)
  • Mhc class ii protein complex
    (GO:0042613)
  • Mhc class ii protein complex binding
    (GO:0023026)
  • Multivesicular body
    (GO:0005771)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:1902166)
  • Negative regulation of mature b cell apoptotic process
    (GO:0002906)
  • Negative regulation of peptide secretion
    (GO:0002792)
  • Negative regulation of t cell differentiation
    (GO:0045581)
  • Negative regulation of viral entry into host cell
    (GO:0046597)
  • Negative thymic t cell selection
    (GO:0045060)
  • Nitric-oxide synthase binding
    (GO:0050998)
  • Nos2-cd74 complex
    (GO:0035693)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of b cell proliferation
    (GO:0030890)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000343)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cytokine-mediated signaling pathway
    (GO:0001961)
  • Positive regulation of cytokine production involved in inflammatory response
    (GO:1900017)
  • Positive regulation of dendritic cell antigen processing and presentation
    (GO:0002606)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of macrophage migration inhibitory factor signaling pathway
    (GO:2000448)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of monocyte differentiation
    (GO:0045657)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of prostaglandin biosynthetic process
    (GO:0031394)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of type 2 immune response
    (GO:0002830)
  • Positive regulation of viral entry into host cell
    (GO:0046598)
  • Positive thymic t cell selection
    (GO:0045059)
  • Prostaglandin biosynthetic process
    (GO:0001516)
  • Protein-containing complex
    (GO:0032991)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein folding
    (GO:0006457)
  • Protein folding chaperone
    (GO:0044183)
  • Protein stabilization
    (GO:0050821)
  • Protein trimerization
    (GO:0070206)
  • Response to type ii interferon
    (GO:0034341)
  • Signal transduction involved in regulation of gene expression
    (GO:0023019)
  • T cell activation involved in immune response
    (GO:0002286)
  • Vacuole
    (GO:0005773)

Other Information

Genular Protein ID: 501463719

Symbol: HG2A_RAT

Name: Ia antigen-associated invariant chain

UniProtKB Accession Codes:

P10247

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 2 Ensembl 4 ExpressionAtlas 1 GO 73 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 2 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2499873

Title: Sequence of a rat MHC class II-associated invariant chain cDNA clone containing a 64 amino acid thyroglobulin-like domain.

PubMed ID: 2499873

DOI: 10.1093/nar/17.10.3983

PubMed ID: 3264906

Title: Nucleotide sequence of rat invariant gamma chain cDNA clone pLR gamma 34.3.

PubMed ID: 3264906

DOI: 10.1093/nar/16.24.11822

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 280
  • Mass: 31642
  • Checksum: D935D169A98B5732
  • Sequence:
    • MDDQRDLISN HEQLPILGQR ARAPESNCNR GVLYTSVSVL VALLLAGQAT TAYFLYQQQG 
RLDKLTVTSQ NLQLENLRMK LPKSAKPVSP MRMATPLLMR PLSMDNMLQA PVKNVTKYGN 
MTQDHVMHLL TKSGPVNYPQ LKGSFPENLK HLKNSMNGLD WKVFESWMKQ WLLFEMSKNS 
LEEKQPTQTP PKVLTKCQEE VSHIPDVHPG AFRPKCDENG NYMPLQCHGS TGYCWCVFPN 
GTEVPHTKSR GRHNCSEPLD MEDPSSGLGV TKQDMGQMFL

Genular Protein ID: 1692583255

Symbol: Q6GT70_RAT

Name: N/A

UniProtKB Accession Codes:

Q6GT70

Database IDs:

AlphaFoldDB 1 CTD 1 EMBL 5 ExpressionAtlas 1 GO 7 Gene3D 1 HOGENOM 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 Pfam 4 Proteomes 1 RGD 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

  • Length: 216
  • Mass: 24503
  • Checksum: 33677FA259B84F8E
  • Sequence:
    • MDDQRDLISN HEQLPILGQR ARAPESNCNR GVLYTSVSVL VALLLAGQAT TAYFLYQQQG 
RLDKLTVTSQ NLQLENLRMK LPKSAKPVSP MRMATPLLMR PLSMDNMLQA PVKNVTKYGN 
MTQDHVMHLL TKSGPVNYPQ LKGSFPENLK HLKNSMNGLD WKVFESWMKQ WLLFEMSKNS 
LEEKQPTQTP PKEPLDMEDP SSGLGVTKQD MGQMFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.