Details for: Oprm1
Associated with
Other Information
Genular Protein ID: 3554677279
Symbol: OPRM_RAT
Name: Mu-type opioid receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8394245
Title: Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.
PubMed ID: 8394245
PubMed ID: 8234282
Title: Mu opiate receptor: cDNA cloning and expression.
PubMed ID: 8234282
PubMed ID: 8393525
Title: Molecular cloning and functional expression of a mu-opioid receptor from rat brain.
PubMed ID: 8393525
PubMed ID: 8240812
Title: Cloning and pharmacological characterization of a rat mu opioid receptor.
PubMed ID: 8240812
PubMed ID: 8189219
Title: Cloning, characterization, and distribution of a mu-opioid receptor in rat brain.
PubMed ID: 8189219
PubMed ID: 15525342
Title: Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy.
PubMed ID: 15525342
PubMed ID: 15057822
Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
PubMed ID: 15057822
DOI: 10.1038/nature02426
PubMed ID: 7733926
Title: Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages.
PubMed ID: 7733926
PubMed ID: 7532594
Title: Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1.
PubMed ID: 7532594
PubMed ID: 1846076
Title: Activation of mu opioid receptors inhibits transient high- and low-threshold Ca2+ currents, but spares a sustained current.
PubMed ID: 1846076
PubMed ID: 7678862
Title: Inhibition of Ca2+ currents by a mu-opioid in a defined subset of rat sensory neurons.
PubMed ID: 7678862
PubMed ID: 8051154
Title: -mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.
PubMed ID: 8051154
PubMed ID: 8624732
Title: The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores.
PubMed ID: 8624732
PubMed ID: 7595566
Title: Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins.
PubMed ID: 7595566
PubMed ID: 9224819
Title: The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation.
PubMed ID: 9224819
DOI: 10.1124/mol.52.1.105
PubMed ID: 9877183
Title: Palmitoylation of the rat mu opioid receptor.
PubMed ID: 9877183
PubMed ID: 9572309
Title: Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C.
PubMed ID: 9572309
PubMed ID: 10488100
Title: Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase.
PubMed ID: 10488100
PubMed ID: 10820022
Title: Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.
PubMed ID: 10820022
DOI: 10.1021/bi991938b
PubMed ID: 10842167
Title: Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.
PubMed ID: 10842167
PubMed ID: 10744734
Title: Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
PubMed ID: 10744734
PubMed ID: 11580279
Title: Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.
PubMed ID: 11580279
DOI: 10.1021/bi0100945
PubMed ID: 11695897
Title: Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.
PubMed ID: 11695897
DOI: 10.1021/bi010917q
PubMed ID: 11060299
Title: Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes.
PubMed ID: 11060299
PubMed ID: 11278523
Title: Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization.
PubMed ID: 11278523
PubMed ID: 12356297
Title: The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the mu opioid receptor and reduces the constitutive activity of its T6.34(279)K mutant.
PubMed ID: 12356297
DOI: 10.1021/bi026067b
PubMed ID: 11896051
Title: Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization.
PubMed ID: 11896051
PubMed ID: 12519790
Title: ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.
PubMed ID: 12519790
PubMed ID: 14645661
Title: Functional interactions between mu opioid and alpha 2A-adrenergic receptors.
PubMed ID: 14645661
PubMed ID: 14729105
Title: Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor.
PubMed ID: 14729105
PubMed ID: 15857684
Title: Biochemical demonstration of mu-opioid receptor association with Gsalpha: enhancement following morphine exposure.
PubMed ID: 15857684
PubMed ID: 15944153
Title: Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes.
PubMed ID: 15944153
PubMed ID: 17384143
Title: Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers.
PubMed ID: 17384143
PubMed ID: 17548356
Title: Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling.
PubMed ID: 17548356
PubMed ID: 17005904
Title: Interaction of the mu-opioid receptor with synaptophysin influences receptor trafficking and signaling.
PubMed ID: 17005904
PubMed ID: 16682964
Title: mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis.
PubMed ID: 16682964
PubMed ID: 18558479
Title: Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins.
PubMed ID: 18558479
PubMed ID: 17947509
Title: Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation.
PubMed ID: 17947509
PubMed ID: 19324084
Title: Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling.
PubMed ID: 19324084
PubMed ID: 19959593
Title: Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy.
PubMed ID: 19959593
PubMed ID: 21292762
Title: Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability.
PubMed ID: 21292762
Sequence Information:
- Length: 398
- Mass: 44494
- Checksum: 9C916DE7C1C33743
- Sequence:
MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.