Lep | ENSRNOG00000045797 | NCBI 25608

Details for: Lep

Gene ID: 25608

Symbol: Lep

Ensembl ID: ENSRNOG00000045797

Description: leptin

Associated with

Incretin synthesis, secretion, and inactivation
(R-RNO-400508)
Metabolism of proteins
(R-RNO-392499)
Peptide hormone metabolism
(R-RNO-2980736)
Synthesis, secretion, and deacylation of ghrelin
(R-RNO-422085)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-RNO-381771)
Adult feeding behavior
(GO:0008343)
Angiogenesis
(GO:0001525)
Aorta development
(GO:0035904)
Bile acid metabolic process
(GO:0008206)
Bone mineralization involved in bone maturation
(GO:0035630)
Camp-mediated signaling
(GO:0019933)
Cardiac muscle hypertrophy
(GO:0003300)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to leptin stimulus
(GO:0044320)
Central nervous system neuron development
(GO:0021954)
Cholesterol metabolic process
(GO:0008203)
Circadian rhythm
(GO:0007623)
Cytokine activity
(GO:0005125)
Determination of adult lifespan
(GO:0008340)
Dna binding
(GO:0003677)
Eating behavior
(GO:0042755)
Energy reserve metabolic process
(GO:0006112)
Fatty acid beta-oxidation
(GO:0006635)
Fatty acid catabolic process
(GO:0009062)
Female pregnancy
(GO:0007565)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Glycerol biosynthetic process
(GO:0006114)
Growth factor activity
(GO:0008083)
Hormone activity
(GO:0005179)
Hormone metabolic process
(GO:0042445)
Insulin secretion
(GO:0030073)
Intracellular signal transduction
(GO:0035556)
Leptin-mediated signaling pathway
(GO:0033210)
Leptin receptor binding
(GO:1990460)
Lipid metabolic process
(GO:0006629)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of appetite
(GO:0032099)
Negative regulation of appetite by leptin-mediated signaling pathway
(GO:0038108)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of metabolic process
(GO:0009892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Ovulation from ovarian follicle
(GO:0001542)
Peptide hormone receptor binding
(GO:0051428)
Phagocytosis
(GO:0006909)
Placenta development
(GO:0001890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of luteinizing hormone secretion
(GO:0033686)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of monoatomic ion transport
(GO:0043270)
Positive regulation of myeloid cell differentiation
(GO:0045639)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of blood pressure
(GO:0008217)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of gluconeogenesis
(GO:0006111)
Regulation of intestinal cholesterol absorption
(GO:0030300)
Regulation of metabolic process
(GO:0019222)
Regulation of natural killer cell activation
(GO:0032814)
Regulation of natural killer cell mediated cytotoxicity
(GO:0042269)
Regulation of natural killer cell proliferation
(GO:0032817)
Regulation of protein phosphorylation
(GO:0001932)
Response to activity
(GO:0014823)
Response to dietary excess
(GO:0002021)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to nutrient
(GO:0007584)
Response to nutrient levels
(GO:0031667)
Response to vitamin e
(GO:0033197)
Sexual reproduction
(GO:0019953)
Signaling receptor binding
(GO:0005102)
T cell differentiation
(GO:0030217)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Leptin

Genular Protein ID: 1709800414

Symbol: LEP_RAT

Name: Leptin

UniProtKB Accession Codes:

P50596

Database IDs:

Citations:

PubMed ID: 7657834

Title: Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats.

PubMed ID: 7657834

DOI: 10.1172/jci118204

PubMed ID: 7794258

Title: Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats.

PubMed ID: 7794258

DOI: 10.1006/bbrc.1995.1837

PubMed ID: 7733988

Title: Cloning of rat obese cDNA and its expression in obese rats.

PubMed ID: 7733988

DOI: 10.1006/bbrc.1995.1589

PubMed ID: 9003024

Title: Leptin activates neurons in ventrobasal hypothalamus and brainstem.

PubMed ID: 9003024

DOI: 10.1210/endo.138.2.5033

PubMed ID: 10482243

Title: Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.

PubMed ID: 10482243

DOI: 10.1016/s0896-6273(01)80035-0

PubMed ID: 11460888

Title: Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro.

PubMed ID: 11460888

DOI: 10.1038/emm.2001.17

PubMed ID: 11677594

Title: Intracellular signaling. Key enzyme in leptin-induced anorexia.

PubMed ID: 11677594

DOI: 10.1038/35101657

PubMed ID: 15122202

Title: The weight of leptin in immunity.

PubMed ID: 15122202

DOI: 10.1038/nri1350

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

Sequence Information:

Length: 167
Mass: 18866
Checksum: 3B5B563DA42EC84E
Sequence:

MCWRPLCRFL WLWSYLSYVQ AVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL 
DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP 
QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lep

Associated with

Other Information

Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. PubMed ID: 7657834

Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. PubMed ID: 7794258

Cloning of rat obese cDNA and its expression in obese rats. PubMed ID: 7733988

Leptin activates neurons in ventrobasal hypothalamus and brainstem. PubMed ID: 9003024

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. PubMed ID: 10482243

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. PubMed ID: 11460888

Intracellular signaling. Key enzyme in leptin-induced anorexia. PubMed ID: 11677594

The weight of leptin in immunity. PubMed ID: 15122202

20 years of leptin: connecting leptin signaling to biological function. PubMed ID: 25232147