Ptk2 | NCBI 25614 - Gene Details

Details for: Ptk2

Gene ID: 25614

Symbol: Ptk2

Description: protein tyrosine kinase 2

Associated with

Actin binding
(GO:0003779)
Angiogenesis
(GO:0001525)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
Blood vessel development
(GO:0001568)
Cell migration
(GO:0016477)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Central nervous system neuron axonogenesis
(GO:0021955)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endothelial cell migration
(GO:0043542)
Ephrin receptor signaling pathway
(GO:0048013)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Extracellular matrix organization
(GO:0030198)
Fat cell differentiation
(GO:0045444)
Growth hormone receptor signaling pathway
(GO:0060396)
Identical protein binding
(GO:0042802)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Intracellular chloride ion homeostasis
(GO:0030644)
Jnk cascade
(GO:0007254)
Jun kinase binding
(GO:0008432)
Mapk cascade
(GO:0000165)
Microtubule cytoskeleton organization
(GO:0000226)
Molecular function activator activity
(GO:0140677)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of axonogenesis
(GO:0050771)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of organ growth
(GO:0046621)
Negative regulation of synapse assembly
(GO:0051964)
Neuron migration
(GO:0001764)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nuclear migration
(GO:0007097)
Nucleus
(GO:0005634)
Organ growth
(GO:0035265)
Phosphatase binding
(GO:0019902)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of macrophage proliferation
(GO:0120041)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of synaptic transmission
(GO:0050806)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Positive regulation of wound healing
(GO:0090303)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of biological quality
(GO:0065008)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cell shape
(GO:0008360)
Regulation of cellular component organization
(GO:0051128)
Regulation of epithelial cell migration
(GO:0010632)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of modification of postsynaptic actin cytoskeleton
(GO:1905274)
Regulation of multicellular organismal process
(GO:0051239)
Regulation of osteoblast differentiation
(GO:0045667)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of substrate adhesion-dependent cell spreading
(GO:1900024)
Response to arsenic-containing substance
(GO:0046685)
Response to estradiol
(GO:0032355)
Response to glucose
(GO:0009749)
Response to mechanical stimulus
(GO:0009612)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to organonitrogen compound
(GO:0010243)
Response to xenobiotic stimulus
(GO:0009410)
Sh2 domain binding
(GO:0042169)
Signal complex assembly
(GO:0007172)
Stress fiber
(GO:0001725)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Vasculogenesis
(GO:0001570)
Vasodilation
(GO:0042311)

Other Information

Proteins

Focal adhesion kinase-related nonkinase

Genular Protein ID: 1649086434

Symbol: FAK1_RAT

Name: Focal adhesion kinase-related nonkinase

UniProtKB Accession Codes:

O35346 Q62900

Database IDs:

Citations:

PubMed ID: 8738136

Title: Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression.

PubMed ID: 8738136

DOI: 10.1016/0169-328x(95)00273-u

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 12732587

Title: Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium.

PubMed ID: 12732587

DOI: 10.1161/01.hyp.0000072772.74183.5f

PubMed ID: 12702722

Title: Direct interaction of focal adhesion kinase with p190RhoGEF.

PubMed ID: 12702722

DOI: 10.1074/jbc.m302381200

PubMed ID: 14500712

Title: PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.

PubMed ID: 14500712

DOI: 10.1074/jbc.m308562200

PubMed ID: 15494733

Title: Focal adhesion kinase in netrin-1 signaling.

PubMed ID: 15494733

DOI: 10.1038/nn1330

PubMed ID: 16373587

Title: Nuclear compartmentalization of FAK and FRNK in cardiac myocytes.

PubMed ID: 16373587

DOI: 10.1152/ajpheart.00659.2005

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1055
Mass: 119717
Checksum: 3AFB4ED682D14A33
Sequence:

MAAAYLDPNL NHTPSSSTKT HLGTGTERSP GAMERVLKVF HYFESSNEPT TWASIIRHGD 
ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW 
KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMLEIA DQVDQDIALK LGCLEIRRSY 
WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI 
LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFNQVQ 
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGATQSFII 
RPQKEGERAL PSIPKLANNE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE 
RIELGRCIGE GQFGDVHQGV YLSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH 
PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK 
RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT 
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA 
YDPSRRPRFT ELKAQLSTIL EEEKVQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY 
PSPRSSEGFY PSPQHMVQTN HYQISGYPGS HGIPAMAGSI YPGQASLLDQ TELWNHRPQE 
MSMWQPSVED SAALDLRGMG QVLPPHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS 
RGSIDREDGS FQGPTGNQHI YQPVGKPDPA APPKKPPRPG APGHLSNLSS ISSPAESYNE 
GVKPWRLQPQ EISPPPTANL DRSNDKVYEN VTGLVKAVIE MSSKIQPAPP EEYVPMVKEV 
GLALRTLLAT VDETIPILPA STHREIEMAQ KLLNSDLGEL ISKMKLAQQY VMTSLQQEYK 
KQMLTAAHAL AVDAKNLLDV IDQARLKMLG QTRPH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptk2

Associated with

Other Information

Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression. PubMed ID: 8738136

Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. PubMed ID: 9422762

Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium. PubMed ID: 12732587

Direct interaction of focal adhesion kinase with p190RhoGEF. PubMed ID: 12702722

PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. PubMed ID: 14500712

Focal adhesion kinase in netrin-1 signaling. PubMed ID: 15494733

Nuclear compartmentalization of FAK and FRNK in cardiac myocytes. PubMed ID: 16373587

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903