Smad3 | ENSRNOG00000008620 | NCBI 25631

Details for: Smad3

Gene ID: 25631

Symbol: Smad3

Ensembl ID: ENSRNOG00000008620

Description: SMAD family member 3

Associated with

Deubiquitination
(R-RNO-5688426)
Developmental biology
(R-RNO-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-RNO-2173795)
Downregulation of tgf-beta receptor signaling
(R-RNO-2173788)
Foxo-mediated transcription
(R-RNO-9614085)
Foxo-mediated transcription of cell cycle genes
(R-RNO-9617828)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Metabolism of proteins
(R-RNO-392499)
Post-translational protein modification
(R-RNO-597592)
Rna polymerase ii transcription
(R-RNO-73857)
Runx3 regulates cdkn1a transcription
(R-RNO-8941855)
Signaling by activin
(R-RNO-1502540)
Signaling by nodal
(R-RNO-1181150)
Signaling by tgf-beta receptor complex
(R-RNO-170834)
Signaling by tgfb family members
(R-RNO-9006936)
Signal transduction
(R-RNO-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-RNO-2173796)
Tgf-beta receptor signaling activates smads
(R-RNO-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-RNO-2173793)
Transcriptional regulation by runx3
(R-RNO-8878159)
Ub-specific processing proteases
(R-RNO-5689880)
Anatomical structure morphogenesis
(GO:0009653)
Apoptotic process
(GO:0006915)
Beta-catenin binding
(GO:0008013)
Bhlh transcription factor binding
(GO:0043425)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Co-smad binding
(GO:0070410)
Collagen binding
(GO:0005518)
Dead/h-box rna helicase binding
(GO:0017151)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity
(GO:0001217)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic pattern specification
(GO:0009880)
Endoderm development
(GO:0007492)
Enzyme binding
(GO:0019899)
Gastrulation
(GO:0007369)
Heart looping
(GO:0001947)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system development
(GO:0002520)
In utero embryonic development
(GO:0001701)
Jnk cascade
(GO:0007254)
Liver development
(GO:0001889)
Mapk cascade
(GO:0000165)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Nuclear mineralocorticoid receptor binding
(GO:0031962)
Nuclear receptor binding
(GO:0016922)
Osteoblast development
(GO:0002076)
Osteoblast differentiation
(GO:0001649)
Phosphatase binding
(GO:0019902)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of striated muscle tissue development
(GO:0016202)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to hypoxia
(GO:0001666)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Skeletal system development
(GO:0001501)
Somitogenesis
(GO:0001756)
Sterol response element binding
(GO:0032810)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription corepressor binding
(GO:0001222)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Mothers against decapentaplegic homolog 3

Genular Protein ID: 2988321211

Symbol: SMAD3_RAT

Name: Mothers against decapentaplegic homolog 3

UniProtKB Accession Codes:

P84025 O09064 O09144 O14510 O35273 Q92940 Q93002 Q9GKR4

Database IDs:

Citations:

PubMed ID: 8917532

Title: Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins.

PubMed ID: 8917532

DOI: 10.1073/pnas.93.23.12992

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11274402

Title: Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling.

PubMed ID: 11274402

DOI: 10.1073/pnas.061358098

PubMed ID: 16619037

Title: Cited2 modulates TGF-beta-mediated upregulation of MMP9.

PubMed ID: 16619037

DOI: 10.1038/sj.onc.1209552

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

Sequence Information:

Length: 425
Mass: 48081
Checksum: 46DF5E8B371321AC
Sequence:

MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV 
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP 
PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL 
NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 
GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF 
EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR 
CSSVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Smad3

Associated with

Other Information

Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. PubMed ID: 8917532

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. PubMed ID: 11274402