Pde4a | ENSRNOG00000020828 | NCBI 25638

Details for: Pde4a

Gene ID: 25638

Symbol: Pde4a

Ensembl ID: ENSRNOG00000020828

Description: phosphodiesterase 4A

Associated with

Darpp-32 events
(R-RNO-180024)
G alpha (i) signalling events
(R-RNO-418594)
G alpha (s) signalling events
(R-RNO-418555)
Gpcr downstream signalling
(R-RNO-388396)
Opioid signalling
(R-RNO-111885)
Signaling by gpcr
(R-RNO-372790)
3',5'-cyclic-amp phosphodiesterase activity
(GO:0004115)
3',5'-cyclic-gmp phosphodiesterase activity
(GO:0047555)
3',5'-cyclic-nucleotide phosphodiesterase activity
(GO:0004114)
Camp-mediated signaling
(GO:0019933)
Camp binding
(GO:0030552)
Camp catabolic process
(GO:0006198)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extrinsic component of membrane
(GO:0019898)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Modulation of chemical synaptic transmission
(GO:0050804)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106070)
Regulation of protein kinase a signaling
(GO:0010738)
Response to xenobiotic stimulus
(GO:0009410)
Schaffer collateral - ca1 synapse
(GO:0098685)
Sensory perception of smell
(GO:0007608)
Signal transduction
(GO:0007165)

Other Information

Proteins

DPDE2

Genular Protein ID: 4294729387

Symbol: PDE4A_RAT

Name: DPDE2

UniProtKB Accession Codes:

P54748 P14645 Q9EQR7

Database IDs:

Citations:

PubMed ID: 2542942

Title: Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

PubMed ID: 2542942

DOI: 10.1073/pnas.86.10.3604

PubMed ID: 7958996

Title: Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases.

PubMed ID: 7958996

DOI: 10.1016/0378-1119(94)90155-4

PubMed ID: 8557632

Title: Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

PubMed ID: 8557632

DOI: 10.1074/jbc.271.2.1065

PubMed ID: 2546153

Title: Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.

PubMed ID: 2546153

DOI: 10.1073/pnas.86.14.5325

PubMed ID: 11306681

Title: Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10.

PubMed ID: 11306681

DOI: 10.1124/mol.59.5.996

PubMed ID: 21323643

Title: Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

PubMed ID: 21323643

DOI: 10.1042/bj20101184

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 8663181

Title: Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs.

PubMed ID: 8663181

DOI: 10.1074/jbc.271.28.16703

Sequence Information:

Length: 844
Mass: 93439
Checksum: 1A5F5101E4DBF1B6
Sequence:

MEPPAAPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYPD SAERSETERS 
PHRPIERADA VDTGDRPGLR TTRMSWPSSF HGTGTGGGSS RRLEAENGPT PSPGRSPLDS 
QASPGLVLHA GATTSQRRES FLYRSDSDYD MSPKAVSRSS SVASEAHAED LIVTPFAQVL 
ASLRSVRSNF SLLTNVPIPS NKRSPLGGPP SVCKATLSEE TCQQLARETL EELDWCLEQL 
ETMQTYRSVS EMASHKFKRM LNRELTHLSE MSRSGNQVSE YISNTFLDKQ NEVEIPSPTP 
RQRAFQQPPP SVLRQSQPMS QITGLKKLVH TGSLNTNVPR FGVKTDQEDL LAQELENLSK 
WGLNIFCVSE YAGGRSLSCI MYTIFQERDL LKKFHIPVDT MMMYMLTLED HYHADVAYHN 
SLHAADVLQS THVLLATPAL DAVFTDLEIL AALFAAAIHD VDHPGVSNQF LINTNSELAL 
MYNDESVLEN HHLAVGFKLL QEENCDIFQN LSKRQRQSLR KMVIDMVLAT DMSKHMTLLA 
DLKTMVETKK VTSSGVLLLD NYSDRIQVLR NMVHCADLSN PTKPLELYRQ WTDRIMAEFF 
QQGDRERERG MEISPMCDKH TASVEKSQVG FIDYIVHPLW ETWADLVHPD AQDILDTLED 
NRDWYHSAIR QSPSPPLEEE PGGLGHPSLP DKFQFELTLE EEEEEDSLEV PGLPTTEETF 
LAAEDARAQA VDWSKVKGPS TTVVEVAERL KQETASAYGA PQESMEAVGC SFSPGTPILP 
DVRTLSSSEE APGLLGLPST AAEVEAPRDH LAATRACSAC SGTSGDNSAI ISAPGRWGSG 
GDPA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pde4a

Associated with

Other Information

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene. PubMed ID: 2542942

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. PubMed ID: 7958996

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8. PubMed ID: 8557632

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. PubMed ID: 2546153

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10. PubMed ID: 11306681

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. PubMed ID: 21323643

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs. PubMed ID: 8663181