Details for: Gnai3

Gene ID: 25643

Symbol: Gnai3

Description: G protein subunit alpha i3

Associated with

Other Information

Genular Protein ID: 3758343460

Symbol: GNAI3_RAT

Name: Guanine nucleotide-binding protein G(i) subunit alpha-3

UniProtKB Accession Codes:

P08753

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 BioGRID 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 DIP 1 EMBL 2 Ensembl 3 GO 29 Gene3D 2 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 RGD 1 Reactome 4 RefSeq 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 2834384

Title: Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.

PubMed ID: 2834384

DOI: 10.1016/s0021-9258(18)68692-2

PubMed ID: 2820999

Title: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

PubMed ID: 2820999

DOI: 10.1016/s0021-9258(18)47929-x

PubMed ID: 2159473

Title: Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

PubMed ID: 2159473

DOI: 10.1016/s0021-9258(19)39064-7

PubMed ID: 11121039

Title: Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.

PubMed ID: 11121039

DOI: 10.1073/pnas.97.26.14364

PubMed ID: 11387333

Title: RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor activity.

PubMed ID: 11387333

DOI: 10.1074/jbc.m103208200

PubMed ID: 16870394

Title: Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.

PubMed ID: 16870394

DOI: 10.1016/j.cellsig.2006.06.002

PubMed ID: 19211784

Title: GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.

PubMed ID: 19211784

DOI: 10.1073/pnas.0900294106

PubMed ID: 20462955

Title: A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.

PubMed ID: 20462955

DOI: 10.1091/mbc.e10-01-0028

PubMed ID: 21653697

Title: G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.

PubMed ID: 21653697

DOI: 10.1074/jbc.m110.204099

PubMed ID: 25187647

Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

PubMed ID: 25187647

DOI: 10.1091/mbc.e14-05-0978

PubMed ID: 31363053

Title: Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.

PubMed ID: 31363053

DOI: 10.1073/pnas.1906658116

PubMed ID: 31570568

Title:

PubMed ID: 31570568

DOI: 10.1073/pnas.1916094116

Sequence Information:

  • Length: 354
  • Mass: 40522
  • Checksum: A65D63CE5A32C777
  • Sequence:
    • MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG 
YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR ADDARQLFVL AGSAEEGVMT 
SELAGVIKRL WRDGGVQACF SRSREYQLND SASYYLNDLD RISQTNYIPT QQDVLRTRVK 
TTGIVETHFT FKELYFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM 
NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKIKR SPLTICYPEY TGSNTYEEAA 
AYIQCQFEDL NRRKDTKEVY THFTCATDTK NVQFVFDAVT DVIIKNNLKE CGLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.