Details for: Scn5a

Gene ID: 25665

Symbol: Scn5a

Ensembl ID: ENSRNOG00000015049

Description: sodium voltage-gated channel alpha subunit 5

Associated with

  • Action potential
    (GO:0001508)
  • Ankyrin binding
    (GO:0030506)
  • Atrial cardiac muscle cell action potential
    (GO:0086014)
  • Av node cell action potential
    (GO:0086016)
  • Av node cell to bundle of his cell communication
    (GO:0086067)
  • Axon
    (GO:0030424)
  • Brainstem development
    (GO:0003360)
  • Bundle of his cell action potential
    (GO:0086043)
  • Calcium ion homeostasis
    (GO:0055074)
  • Calmodulin binding
    (GO:0005516)
  • Cardiac muscle cell action potential involved in contraction
    (GO:0086002)
  • Cardiac muscle contraction
    (GO:0060048)
  • Cardiac ventricle development
    (GO:0003231)
  • Caveola
    (GO:0005901)
  • Cell communication involved in cardiac conduction
    (GO:0086065)
  • Cell surface
    (GO:0009986)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cerebellum development
    (GO:0021549)
  • Endoplasmic reticulum
    (GO:0005783)
  • Enzyme binding
    (GO:0019899)
  • Establishment of localization in cell
    (GO:0051649)
  • Fibroblast growth factor binding
    (GO:0017134)
  • Intercalated disc
    (GO:0014704)
  • Lateral plasma membrane
    (GO:0016328)
  • Membrane
    (GO:0016020)
  • Membrane depolarization
    (GO:0051899)
  • Membrane depolarization during action potential
    (GO:0086010)
  • Membrane depolarization during atrial cardiac muscle cell action potential
    (GO:0098912)
  • Membrane depolarization during av node cell action potential
    (GO:0086045)
  • Membrane depolarization during bundle of his cell action potential
    (GO:0086048)
  • Membrane depolarization during cardiac muscle cell action potential
    (GO:0086012)
  • Membrane depolarization during purkinje myocyte cell action potential
    (GO:0086047)
  • Membrane depolarization during sa node cell action potential
    (GO:0086046)
  • Muscle cell cellular homeostasis
    (GO:0046716)
  • Neuronal action potential
    (GO:0019228)
  • Nitric-oxide synthase binding
    (GO:0050998)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of action potential
    (GO:0045760)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of heart rate
    (GO:0010460)
  • Positive regulation of sodium ion transport
    (GO:0010765)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of atrial cardiac muscle cell membrane depolarization
    (GO:0060371)
  • Regulation of atrial cardiac muscle cell membrane repolarization
    (GO:0060372)
  • Regulation of cardiac muscle cell contraction
    (GO:0086004)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of sodium ion transmembrane transport
    (GO:1902305)
  • Regulation of ventricular cardiac muscle cell membrane depolarization
    (GO:0060373)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Response to denervation involved in regulation of muscle adaptation
    (GO:0014894)
  • Response to organic cyclic compound
    (GO:0014070)
  • Sa node cell action potential
    (GO:0086015)
  • Sarcolemma
    (GO:0042383)
  • Scaffold protein binding
    (GO:0097110)
  • Sodium channel complex
    (GO:0034706)
  • Sodium ion import across plasma membrane
    (GO:0098719)
  • Sodium ion transmembrane transport
    (GO:0035725)
  • Sodium ion transport
    (GO:0006814)
  • T-tubule
    (GO:0030315)
  • Telencephalon development
    (GO:0021537)
  • Transmembrane transporter binding
    (GO:0044325)
  • Ubiquitin protein ligase binding
    (GO:0031625)
  • Ventricular cardiac muscle cell action potential
    (GO:0086005)
  • Voltage-gated sodium channel activity
    (GO:0005248)
  • Voltage-gated sodium channel activity involved in av node cell action potential
    (GO:0086060)
  • Voltage-gated sodium channel activity involved in bundle of his cell action potential
    (GO:0086061)
  • Voltage-gated sodium channel activity involved in cardiac muscle cell action potential
    (GO:0086006)
  • Voltage-gated sodium channel activity involved in purkinje myocyte action potential
    (GO:0086062)
  • Voltage-gated sodium channel activity involved in sa node cell action potential
    (GO:0086063)
  • Voltage-gated sodium channel complex
    (GO:0001518)
  • Z disc
    (GO:0030018)

Other Information

Genular Protein ID: 4044388210

Symbol: SCN5A_RAT

Name: Sodium channel protein type 5 subunit alpha

UniProtKB Accession Codes:

P15389 Q925G6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 BMRB 1 BindingDB 1 BioGRID 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DrugCentral 1 EMBL 2 GO 70 Gene3D 4 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 UCSC 1 UniProtKB 4 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2554302

Title: Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform.

PubMed ID: 2554302

DOI: 10.1073/pnas.86.20.8170

PubMed ID: 9417050

Title: A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.

PubMed ID: 9417050

DOI: 10.1074/jbc.273.1.80

PubMed ID: 15579534

Title: Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.

PubMed ID: 15579534

DOI: 10.1073/pnas.0403711101

PubMed ID: 18386309

Title: New variants of Nav1.5/SCN5A encode Na+ channels in the brain.

PubMed ID: 18386309

DOI: 10.1080/01677060701672077

PubMed ID: 19661460

Title: Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes.

PubMed ID: 19661460

DOI: 10.1161/circresaha.109.201418

PubMed ID: 19376164

Title: Analysis of four novel variants of Nav1.5/SCN5A cloned from the brain.

PubMed ID: 19376164

DOI: 10.1016/j.neures.2009.04.003

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 24497506

Title: A disulfide tether stabilizes the block of sodium channels by the conotoxin muO[section sign]-GVIIJ.

PubMed ID: 24497506

DOI: 10.1073/pnas.1324189111

PubMed ID: 26039939

Title: Probing the redox states of sodium channel cysteines at the binding site of muO[section sign]-conotoxin GVIIJ.

PubMed ID: 26039939

DOI: 10.1021/acs.biochem.5b00390

Sequence Information:

  • Length: 2019
  • Mass: 227367
  • Checksum: CFC3B03CEAE708AD
  • Sequence:
    • MANLLLPRGT SSFRRFTRES LAAIEKRMAE KQARGGSATS QESREGLQEE EAPRPQLDLQ 
ASKKLPDLYG NPPRELIGEP LEDLDPFYST QKTFIVLNKG KTIFRFSATN ALYVLSPFHP 
VRRAAVKILV HSLFSMLIMC TILTNCVFMA QHDPPPWTKY VEYTFTAIYT FESLVKILAR 
GFCLHAFTFL RDPWNWLDFS VIVMAYTTEF VDLGNVSALR TFRVLRALKT ISVISGLKTI 
VGALIQSVKK LADVMVLTVF CLSVFALIGL QLFMGNLRHK CVRNFTELNG TNGSVEADGL 
VWNSLDVYLN DPANYLLKNG TTDVLLCGNS SDAGTCPEGY RCLKAGENPD HGYTSFDSFA 
WAFLALFRLM TQDCWERLYQ QTLRSAGKIY MIFFMLVIFL GSFYLVNLIL AVVAMAYEEQ 
NQATIAETEE KEKRFQEAME MLKKEHEALT IRGVDTVSRS SLEMSPLAPV TNHERKSKRR 
KRLSSGTEDG GDDRLPKSDS EDGPRALNQL SLTHGLSRTS MRPRSSRGSI FTFRRRDQGS 
EADFADDENS TAGESESHRT SLLVPWPLRH PSAQGQPGPG ASAPGYVLNG KRNSTVDCNG 
VVSLLGAGDA EATSPGSYLL RPMVLDRPPD TTTPSEEPGG PQMLTPQAPC ADGFEEPGAR 
QRALSAVSVL TSALEELEES HRKCPPCWNR FAQHYLIWEC CPLWMSIKQK VKFVVMDPFA 
DLTITMCIVL NTLFMALEHY NMTAEFEEML QVGNLVFTGI FTAEMTFKII ALDPYYYFQQ 
GWNIFDSIIV ILSLMELGLS RMGNLSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL 
GNLTLVLAII VFIFAVVGMQ LFGKNYSELR HRISDSGLLP RWHMMDFFHA FLIIFRILCG 
EWIETMWDCM EVSGQSLCLL VFLLVMVIGN LVVLNLFLAL LLSSFSADNL TAPDEDGEMN 
NLQLALARIQ RGLRFVKRTT WDFCCGILRR RPKKPAALAT HSQLPSCITA PRSPPPPEVE 
KVPPARKETR FEEDKRPGQG TPGDSEPVCV PIAVAESDTE DQEEDEENSL GTEEESSKQE 
SQVVSGGHEP YQEPRAWSQV SETTSSEAGA STSQADWQQE QKTEPQAPGC GETPEDSYSE 
GSTADMTNTA DLLEQIPDLG EDVKDPEDCF TEGCVRRCPC CMVDTTQSPG KVWWRLRKTC 
YRIVEHSWFE TFIIFMILLS SGALAFEDIY LEERKTIKVL LEYADKMFTY VFVLEMLLKW 
VAYGFKKYFT NAWCWLDFLI VDVSLVSLVA NTLGFAEMGP IKSLRTLRAL RPLRALSRFE 
GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFGRCINQTE GDLPLNYTIV 
NNKSECESFN VTGELYWTKV KVNFDNVGAG YLALLQVATF KGWMDIMYAA VDSRGYEEQP 
QWEDNLYMYI YFVVFIIFGS FFTLNLFIGV IIDNFNQQKK KLGGQDIFMT EEQKKYYNAM 
KKLGSKKPQK PIPRPLNKYQ GFIFDIVTKQ AFDVTIMFLI CLNMVTMMVE TDDQSPEKVN 
ILAKINLLFV AIFTGECIVK MAALRHYYFT NSWNIFDFVV VILSIVGTVL SDIIQKYFFS 
PTLFRVIRLA RIGRILRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMAN 
FAYVKWEAGI DDMFNFQTFA NSMLCLFQIT TSAGWDGLLS PILNTGPPYC DPNLPNSNGS 
RGNCGSPAVG ILFFTTYIII SFLIVVNMYI AIILENFSVA TEESTEPLSE DDFDMFYEIW 
EKFDPEATQF IEYLALSDFA DALSEPLRIA KPNQISLINM DLPMVSGDRI HCMDILFAFT 
KRVLGESGEM DALKIQMEEK FMAANPSKIS YEPITTTLRR KHEEVSATVI QRAFRRHLLQ 
RSVKHASFLF RQQAGGSGLS DEDAPEREGL IAYMMNGNFS RRSAPLSSSS ISSTSFPPSY 
DSVTRATSDN LPVRASDYSR SEDLADFPPS PDRDRESIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.