Details for: Gnai1
Associated with
Other Information
Genular Protein ID: 380347121
Symbol: GNAI1_RAT
Name: Guanine nucleotide-binding protein G(i) subunit alpha-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2820999
Title: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.
PubMed ID: 2820999
PubMed ID: 11121039
Title: Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.
PubMed ID: 11121039
PubMed ID: 11387333
Title: RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor activity.
PubMed ID: 11387333
PubMed ID: 16870394
Title: Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization.
PubMed ID: 16870394
PubMed ID: 17635935
Title: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.
PubMed ID: 17635935
PubMed ID: 19211784
Title: GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.
PubMed ID: 19211784
PubMed ID: 21158412
Title: Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.
PubMed ID: 21158412
DOI: 10.1021/bi101910n
PubMed ID: 21653697
Title: G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.
PubMed ID: 21653697
PubMed ID: 26253820
Title: G protein-membrane interactions I: Galphai1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization.
PubMed ID: 26253820
PubMed ID: 8073283
Title: Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
PubMed ID: 8073283
PubMed ID: 8521505
Title: The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
PubMed ID: 8521505
PubMed ID: 9108480
Title: Structure of RGS4 bound to AlF4-activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
PubMed ID: 9108480
PubMed ID: 9772163
Title: Crystal structures of the G protein Gi alpha 1 complexed with GDP and Mg2+: a crystallographic titration experiment.
PubMed ID: 9772163
DOI: 10.1021/bi9810306
PubMed ID: 9705312
Title: The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.
PubMed ID: 9705312
PubMed ID: 19703466
Title: Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins.
PubMed ID: 19703466
PubMed ID: 24596087
Title: A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Galphai1.
PubMed ID: 24596087
PubMed ID: 25037222
Title: A conserved phenylalanine as a relay between the alpha5 helix and the GDP binding region of heterotrimeric Gi protein alpha subunit.
PubMed ID: 25037222
Sequence Information:
- Length: 354
- Mass: 40345
- Checksum: 99E9D11B485C2DE3
- Sequence:
MGCTLSAEDK AAVERSKMID RNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEAG YSEEECKQYK AVVYSNTIQS IIAIIRAMGR LKIDFGDAAR ADDARQLFVL AGAAEEGFMT AELAGVIKRL WKDSGVQACF NRSREYQLND SAAYYLNDLD RIAQPNYIPT QQDVLRTRVK TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKIKK SPLTICYPEY AGSNTYEEAA AYIQCQFEDL NKRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.