Ctsl | ENSRNOG00000018566 | NCBI 25697

Details for: Ctsl

Gene ID: 25697

Symbol: Ctsl

Ensembl ID: ENSRNOG00000018566

Description: cathepsin L

Associated with

Activation of matrix metalloproteinases
(R-RNO-1592389)
Adaptive immune system
(R-RNO-1280218)
Assembly of collagen fibrils and other multimeric structures
(R-RNO-2022090)
Collagen formation
(R-RNO-1474290)
Degradation of the extracellular matrix
(R-RNO-1474228)
Extracellular matrix organization
(R-RNO-1474244)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Mhc class ii antigen presentation
(R-RNO-2132295)
Rna polymerase ii transcription
(R-RNO-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-RNO-8939242)
Toll-like receptor cascades
(R-RNO-168898)
Trafficking and processing of endosomal tlr
(R-RNO-1679131)
Transcriptional regulation by runx1
(R-RNO-8878171)
Adaptive immune response
(GO:0002250)
Aminopeptidase activity
(GO:0004177)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Apoptotic process
(GO:0006915)
Autophagic cell death
(GO:0048102)
Cd4-positive, alpha-beta t cell lineage commitment
(GO:0043373)
Cellular response to starvation
(GO:0009267)
Cellular response to thyroid hormone stimulus
(GO:0097067)
Chromaffin granule
(GO:0042583)
Collagen binding
(GO:0005518)
Collagen catabolic process
(GO:0030574)
Cysteine-type carboxypeptidase activity
(GO:0016807)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasmic vesicle
(GO:0031410)
Decidualization
(GO:0046697)
Elastin catabolic process
(GO:0060309)
Endopeptidase activity
(GO:0004175)
Enkephalin processing
(GO:0034230)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Fusion of virus membrane with host endosome membrane
(GO:0039654)
Fusion of virus membrane with host plasma membrane
(GO:0019064)
Golgi apparatus
(GO:0005794)
Hair follicle morphogenesis
(GO:0031069)
Histone binding
(GO:0042393)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Keratinocyte proliferation
(GO:0043616)
Kininogen binding
(GO:0030984)
Lysosome
(GO:0005764)
Male gonad development
(GO:0008584)
Microvillus
(GO:0005902)
Multivesicular body
(GO:0005771)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Nerve development
(GO:0021675)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Peptide binding
(GO:0042277)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of peptidase activity
(GO:0010952)
Protein-containing complex binding
(GO:0044877)
Protein autoprocessing
(GO:0016540)
Protein catabolic process
(GO:0030163)
Protein processing
(GO:0016485)
Proteoglycan binding
(GO:0043394)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Regulation of actin cytoskeleton organization
(GO:0032956)
Response to glucocorticoid
(GO:0051384)
Response to glucose
(GO:0009749)
Response to gonadotropin
(GO:0034698)
Response to odorant
(GO:1990834)
Response to organic cyclic compound
(GO:0014070)
Secretory granule
(GO:0030141)
Serpin family protein binding
(GO:0097655)
Sertoli cell differentiation
(GO:0060008)
Spermatogenesis
(GO:0007283)
Symbiont entry into host cell
(GO:0046718)
Thyroid hormone generation
(GO:0006590)
Zymogen activation
(GO:0031638)

Other Information

Proteins

Procathepsin L

Genular Protein ID: 2262042549

Symbol: CATL1_RAT

Name: Procathepsin L

UniProtKB Accession Codes:

P07154 Q9QV07

Database IDs:

Citations:

PubMed ID: 3666143

Title: Molecular cloning and sequencing of cDNA for rat cathepsin L.

PubMed ID: 3666143

DOI: 10.1016/0014-5793(87)80511-2

PubMed ID: 2599113

Title: Gene structure and 5'-upstream sequence of rat cathepsin L.

PubMed ID: 2599113

DOI: 10.1016/0014-5793(89)81497-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11356678

Title: Male germ cells regulate transcription of the cathepsin L gene by rat Sertoli cells.

PubMed ID: 11356678

DOI: 10.1210/endo.142.6.8106

PubMed ID: 1791830

Title: Cyclic protein-2, a secretory product of rat Sertoli cells, is the proenzyme form of cathepsin L.

PubMed ID: 1791830

DOI: 10.1210/mend-5-12-1789

PubMed ID: 7777858

Title: Identification of a stimulator of steroid hormone synthesis isolated from testis.

PubMed ID: 7777858

DOI: 10.1126/science.7777858

PubMed ID: 10699763

Title: Precursor of rat epidermal cathepsin L: purification and immunohistochemical localization.

PubMed ID: 10699763

DOI: 10.1016/s0923-1811(99)00063-8

PubMed ID: 3402618

Title: Amino acid sequence of rat liver cathepsin L.

PubMed ID: 3402618

DOI: 10.1016/0014-5793(88)80285-0

PubMed ID: 26479776

Title: Peptidomics for studying limited proteolysis.

PubMed ID: 26479776

DOI: 10.1021/acs.jproteome.5b00820

Sequence Information:

Length: 334
Mass: 37660
Checksum: AFFA997582E34AF6
Sequence:

MTPLLLLAVL CLGTALATPK FDQTFNAQWH QWKSTHRRLY GTNEEEWRRA VWEKNMRMIQ 
LHNGEYSNGK HGFTMEMNAF GDMTNEEFRQ IVNGYRHQKH KKGRLFQEPL MLQIPKTVDW 
REKGCVTPVK NQGQCGSCWA FSASGCLEGQ MFLKTGKLIS LSEQNLVDCS HDQGNQGCNG 
GLMDFAFQYI KENGGLDSEE SYPYEAKDGS CKYRAEYAVA NDTGFVDIPQ QEKALMKAVA 
TVGPISVAMD ASHPSLQFYS SGIYYEPNCS SKDLDHGVLV VGYGYEGTDS NKDKYWLVKN 
SWGKEWGMDG YIKIAKDRNN HCGLATAASY PIVN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ctsl

Associated with

Other Information

Molecular cloning and sequencing of cDNA for rat cathepsin L. PubMed ID: 3666143

Gene structure and 5'-upstream sequence of rat cathepsin L. PubMed ID: 2599113

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Male germ cells regulate transcription of the cathepsin L gene by rat Sertoli cells. PubMed ID: 11356678

Cyclic protein-2, a secretory product of rat Sertoli cells, is the proenzyme form of cathepsin L. PubMed ID: 1791830

Identification of a stimulator of steroid hormone synthesis isolated from testis. PubMed ID: 7777858

Precursor of rat epidermal cathepsin L: purification and immunohistochemical localization. PubMed ID: 10699763

Amino acid sequence of rat liver cathepsin L. PubMed ID: 3402618

Peptidomics for studying limited proteolysis. PubMed ID: 26479776