Details for: ALX3

Gene ID: 257

Symbol: ALX3

Ensembl ID: ENSG00000156150

Description: ALX homeobox 3

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Mitf-m-regulated melanocyte development
    (R-HSA-9730414)
  • Transcriptional and post-translational regulation of mitf-m expression and activity
    (R-HSA-9856649)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic hindlimb morphogenesis
    (GO:0035116)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.8383
    Cell Significance Index: -3.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1856
    Cell Significance Index: 18.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3132
    Cell Significance Index: 6.5600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2189
    Cell Significance Index: 3.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1941
    Cell Significance Index: 4.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0589
    Cell Significance Index: 0.8700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.0464
    Cell Significance Index: 0.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0349
    Cell Significance Index: 1.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0228
    Cell Significance Index: 0.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0180
    Cell Significance Index: 3.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0026
    Cell Significance Index: 1.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0024
    Cell Significance Index: 0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0023
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0017
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0031
    Cell Significance Index: -1.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0043
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0064
    Cell Significance Index: -1.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0071
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0079
    Cell Significance Index: -0.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0087
    Cell Significance Index: -0.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0109
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0112
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0112
    Cell Significance Index: -1.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0115
    Cell Significance Index: -2.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0130
    Cell Significance Index: -0.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0132
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0140
    Cell Significance Index: -2.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0149
    Cell Significance Index: -0.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0162
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0209
    Cell Significance Index: -2.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0242
    Cell Significance Index: -1.4900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0281
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0327
    Cell Significance Index: -3.4000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0338
    Cell Significance Index: -0.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0352
    Cell Significance Index: -2.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0361
    Cell Significance Index: -0.9000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0398
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0404
    Cell Significance Index: -1.1000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0412
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0421
    Cell Significance Index: -1.9100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0443
    Cell Significance Index: -0.7100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0456
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0457
    Cell Significance Index: -3.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0461
    Cell Significance Index: -3.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0468
    Cell Significance Index: -6.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0489
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0506
    Cell Significance Index: -2.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0520
    Cell Significance Index: -0.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0535
    Cell Significance Index: -1.0500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0556
    Cell Significance Index: -0.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0610
    Cell Significance Index: -2.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0633
    Cell Significance Index: -1.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0651
    Cell Significance Index: -0.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0654
    Cell Significance Index: -3.0800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0686
    Cell Significance Index: -0.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0728
    Cell Significance Index: -1.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0733
    Cell Significance Index: -5.0700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0744
    Cell Significance Index: -0.8200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0766
    Cell Significance Index: -1.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0784
    Cell Significance Index: -2.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0786
    Cell Significance Index: -0.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0791
    Cell Significance Index: -0.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0806
    Cell Significance Index: -2.0100
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0810
    Cell Significance Index: -0.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0825
    Cell Significance Index: -6.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0851
    Cell Significance Index: -0.8200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0851
    Cell Significance Index: -0.9300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0861
    Cell Significance Index: -1.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0861
    Cell Significance Index: -3.8100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0870
    Cell Significance Index: -0.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0874
    Cell Significance Index: -4.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0889
    Cell Significance Index: -3.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0893
    Cell Significance Index: -1.5300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0945
    Cell Significance Index: -1.2400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0948
    Cell Significance Index: -1.0600
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0955
    Cell Significance Index: -1.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0957
    Cell Significance Index: -2.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0992
    Cell Significance Index: -3.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0999
    Cell Significance Index: -3.2700
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1020
    Cell Significance Index: -1.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1030
    Cell Significance Index: -2.5000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1034
    Cell Significance Index: -1.0700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1064
    Cell Significance Index: -0.8400
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1099
    Cell Significance Index: -1.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1116
    Cell Significance Index: -2.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1117
    Cell Significance Index: -4.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1118
    Cell Significance Index: -1.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** ALX3 is a transcription factor that regulates the expression of target genes involved in developmental processes, cell fate determination, and tissue homeostasis. 2. **Homeobox domain:** The ALX3 protein contains a homeobox domain, which is a conserved DNA-binding motif that recognizes and binds to specific DNA sequences, thereby regulating gene expression. 3. **Wnt/β-catenin signaling:** ALX3 interacts with the Wnt/β-catenin signaling pathway, a key regulator of embryonic development and tissue homeostasis. 4. **Immunological significance:** ALX3 is expressed in immune cells, including GABAergic interneurons in the cerebral cortex, suggesting its potential role in immune system regulation. **Pathways and Functions:** 1. **Embryonic morphogenesis:** ALX3 regulates the development of embryonic tissues, including the forelimb and hindlimb, through its interaction with the Wnt/β-catenin signaling pathway. 2. **Pattern specification:** ALX3 plays a crucial role in pattern specification during embryonic development, ensuring the correct formation of tissues and organs. 3. **Transcriptional regulation:** ALX3 regulates the expression of target genes involved in cell fate determination, tissue homeostasis, and immune system development. 4. **Apoptosis regulation:** ALX3 interacts with the regulation of apoptotic processes, influencing cell survival and death in various tissues. **Clinical Significance:** 1. **Immune system dysregulation:** ALX3 expression in immune cells suggests its potential role in immune system dysregulation, including autoimmune diseases and cancer. 2. **Cancer development:** ALX3 expression in cancer cells, including colon and kidney cancer, suggests its involvement in tumor development and progression. 3. **Neurological disorders:** ALX3 expression in GABAergic interneurons in the cerebral cortex suggests its potential role in neurological disorders, including epilepsy and schizophrenia. 4. **Regenerative medicine:** ALX3's role in tissue homeostasis and regeneration makes it a potential target for regenerative medicine therapies. In conclusion, ALX3 is a multifunctional transcription factor that plays a crucial role in developmental biology, immune system regulation, and tissue homeostasis. Further research is needed to fully elucidate its clinical significance and potential therapeutic applications in various diseases.

Genular Protein ID: 454557686

Symbol: ALX3_HUMAN

Name: Homeobox protein aristaless-like 3

UniProtKB Accession Codes:

O95076 O95075 Q5T8M4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11807986

Title: Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma.

PubMed ID: 11807986

DOI: 10.1002/gcc.10030

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19409524

Title: Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.

PubMed ID: 19409524

DOI: 10.1016/j.ajhg.2009.04.009

Sequence Information:

  • Length: 343
  • Mass: 36935
  • Checksum: 0BB20630D5CB817B
  • Sequence:
    • MDPEHCAPFR VGPAPGPYVA SGDEPPGPQG TPAAAPHLHP APPRGPRLTR FPACGPLEPY 
LPEPAKPPAK YLQDLGPGPA LNGGHFYEGP AEAEEKTSKA ASFPQLPLDC RGGPRDGPSN 
LQGSPGPCLA SLHLPLSPGL PDSMELAKNK SKKRRNRTTF STFQLEELEK VFQKTHYPDV 
YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKIQEG RNPFTAAYDI SVLPRTDSHP 
QLQNSLWASP GSGSPGGPCL VSPEGIPSPC MSPYSHPHGS VAGFMGVPAP SAAHPGIYSI 
HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN WTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.