Details for: ALX3

Gene ID: 257

Symbol: ALX3

Ensembl ID: ENSG00000156150

Description: ALX homeobox 3

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic hindlimb morphogenesis
    (GO:0035116)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.49
    Marker Score: 3347
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.57
    Marker Score: 7361.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1178
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.42
    Marker Score: 1413
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4829
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.06
    Marker Score: 2192
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71842.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48067
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.43
    Marker Score: 819
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.38
    Marker Score: 188
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5753
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.31
    Marker Score: 537
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 623
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.3
    Marker Score: 158.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.3
    Marker Score: 432
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.29
    Marker Score: 67
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.26
    Marker Score: 304
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 176
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 478
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 375
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.14
    Marker Score: 314
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.1
    Marker Score: 140
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.08
    Marker Score: 736
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.07
    Marker Score: 395
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.04
    Marker Score: 8
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 186
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.03
    Marker Score: 407.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.03
    Marker Score: 113
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.03
    Marker Score: 349
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.02
    Marker Score: 67
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.02
    Marker Score: 54
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.02
    Marker Score: 75
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.02
    Marker Score: 6

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - ALX3 is a member of the ALX family of homeobox genes. - It is expressed in a variety of cell types, including retina horizontal cells, retinal cone cells, colon goblet cells, enterocytes of the epithelium of the large intestine, intestinal crypt stem cells of the small intestine, transit amplifying cells of the small intestine, enterocytes of the epithelium of the small intestine, transit amplifying cells of the colon, kidney proximal convoluted tubule epithelial cells, and cerebral cortex GABAergic interneurons. - It is a key regulator of embryonic forelimb and hindlimb morphogenesis. **Pathways and functions:** - ALX3 is a key regulator of embryonic forelimb and hindlimb morphogenesis. - It is required for the development of the optic nerve and the surrounding tissue in the eye. - It is also required for the development of the inner ear and the surrounding tissue. - ALX3 is also involved in the regulation of apoptosis. **Clinical significance:** - Mutations in the ALX3 gene have been linked to a number of human diseases, including retinitis pigmentosa, which is an eye disorder that is caused by mutations in genes that are involved in the development of the retina. - ALX3 is also a potential therapeutic target for cancer. - Inhibition of ALX3 has been shown to inhibit cancer cell growth and migration. - Therefore, ALX3 is a promising target for the treatment of cancer.

Genular Protein ID: 454557686

Symbol: ALX3_HUMAN

Name: Homeobox protein aristaless-like 3

UniProtKB Accession Codes:

O95076 O95075 Q5T8M4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11807986

Title: Combined restriction landmark genomic scanning and virtual genome scans identify a novel human homeobox gene, ALX3, that is hypermethylated in neuroblastoma.

PubMed ID: 11807986

DOI: 10.1002/gcc.10030

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19409524

Title: Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene.

PubMed ID: 19409524

DOI: 10.1016/j.ajhg.2009.04.009

Sequence Information:

  • Length: 343
  • Mass: 36935
  • Checksum: 0BB20630D5CB817B
  • Sequence:
    • MDPEHCAPFR VGPAPGPYVA SGDEPPGPQG TPAAAPHLHP APPRGPRLTR FPACGPLEPY 
LPEPAKPPAK YLQDLGPGPA LNGGHFYEGP AEAEEKTSKA ASFPQLPLDC RGGPRDGPSN 
LQGSPGPCLA SLHLPLSPGL PDSMELAKNK SKKRRNRTTF STFQLEELEK VFQKTHYPDV 
YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKIQEG RNPFTAAYDI SVLPRTDSHP 
QLQNSLWASP GSGSPGGPCL VSPEGIPSPC MSPYSHPHGS VAGFMGVPAP SAAHPGIYSI 
HGFPPTLGGH SFEPSSDGDY KSPSLVSLRV KPKEPPGLLN WTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.