Details for: Kcnb1
Associated with
Other Information
Genular Protein ID: 1957216362
Symbol: KCNB1_RAT
Name: Voltage-gated potassium channel subunit Kv2.1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2770868
Title: A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.
PubMed ID: 2770868
DOI: 10.1038/340642a0
PubMed ID: 1740690
Title: Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies.
PubMed ID: 1740690
PubMed ID: 2206531
Title: Alteration and restoration of K+ channel function by deletions at the N- and C-termini.
PubMed ID: 2206531
PubMed ID: 1875913
Title: Patterns of internal and external tetraethylammonium block in four homologous K+ channels.
PubMed ID: 1875913
PubMed ID: 1961744
Title: Immunological identification and characterization of a delayed rectifier K+ channel polypeptide in rat brain.
PubMed ID: 1961744
PubMed ID: 8508921
Title: Expression of Kv2.1 delayed rectifier K+ channel isoforms in the developing rat brain.
PubMed ID: 8508921
PubMed ID: 8463836
Title: Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily.
PubMed ID: 8463836
PubMed ID: 8083226
Title: Properties of Kv2.1 K+ channels expressed in transfected mammalian cells.
PubMed ID: 8083226
PubMed ID: 7623158
Title: Association and colocalization of K+ channel alpha- and beta-subunit polypeptides in rat brain.
PubMed ID: 7623158
PubMed ID: 7576642
Title: An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula.
PubMed ID: 7576642
PubMed ID: 8978827
Title: Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel.
PubMed ID: 8978827
PubMed ID: 8670833
Title: Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.
PubMed ID: 8670833
PubMed ID: 8980147
Title: Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.
PubMed ID: 8980147
PubMed ID: 9362476
Title: Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes.
PubMed ID: 9362476
PubMed ID: 9079713
Title: Modes of regulation of shab K+ channel activity by the Kv8.1 subunit.
PubMed ID: 9079713
PubMed ID: 9305895
Title: New modulatory alpha subunits for mammalian Shab K+ channels.
PubMed ID: 9305895
PubMed ID: 9351973
Title: Phosphorylation of the Kv2.1 K+ channel alters voltage-dependent activation.
PubMed ID: 9351973
DOI: 10.1124/mol.52.5.821
PubMed ID: 9696692
Title: Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits.
PubMed ID: 9696692
PubMed ID: 9616203
Title: Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.
PubMed ID: 9616203
DOI: 10.1172/jci333
PubMed ID: 9565597
Title: Cloning and expression of a novel K+ channel regulatory protein, KChAP.
PubMed ID: 9565597
PubMed ID: 9522360
Title: The K+ channel, Kv2.1, is apposed to astrocytic processes and is associated with inhibitory postsynaptic membranes in hippocampal and cortical principal neurons and inhibitory interneurons.
PubMed ID: 9522360
PubMed ID: 10414301
Title: Molecular diversity of K+ channels.
PubMed ID: 10414301
PubMed ID: 10024359
Title: Identification of the Kv2.1 K+ channel as a major component of the delayed rectifier K+ current in rat hippocampal neurons.
PubMed ID: 10024359
PubMed ID: 10414968
Title: Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels.
PubMed ID: 10414968
PubMed ID: 10618149
Title: Frequency-dependent regulation of rat hippocampal somato-dendritic excitability by the K+ channel subunit Kv2.1.
PubMed ID: 10618149
PubMed ID: 10719893
Title: A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons.
PubMed ID: 10719893
PubMed ID: 11463864
Title: Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.
PubMed ID: 11463864
PubMed ID: 12451110
Title: Delayed rectifier K+ currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons.
PubMed ID: 12451110
PubMed ID: 12127166
Title: Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells.
PubMed ID: 12127166
PubMed ID: 12403834
Title: Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
PubMed ID: 12403834
DOI: 10.1210/me.2002-0058
PubMed ID: 12065754
Title: Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies.
PubMed ID: 12065754
DOI: 10.1124/mol.62.1.48
PubMed ID: 12560340
Title: The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel.
PubMed ID: 12560340
PubMed ID: 12615930
Title: Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon.
PubMed ID: 12615930
PubMed ID: 12621036
Title: Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.
PubMed ID: 12621036
PubMed ID: 12807875
Title: Direct interaction of target SNAREs with the Kv2.1 channel. Modal regulation of channel activation and inactivation gating.
PubMed ID: 12807875
PubMed ID: 12832499
Title: Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels.
PubMed ID: 12832499
PubMed ID: 12954870
Title: MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain.
PubMed ID: 12954870
PubMed ID: 15322114
Title: NFATc3 regulates Kv2.1 expression in arterial smooth muscle.
PubMed ID: 15322114
PubMed ID: 15195093
Title: Regulation of ion channel localization and phosphorylation by neuronal activity.
PubMed ID: 15195093
DOI: 10.1038/nn1260
PubMed ID: 15858231
Title: Molecular determinants of voltage-gated potassium currents in vascular smooth muscle.
PubMed ID: 15858231
DOI: 10.1385/cbb:42:2:167
PubMed ID: 15855232
Title: Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains.
PubMed ID: 15855232
DOI: 10.1242/jcs.02348
PubMed ID: 16319318
Title: Calcium- and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia.
PubMed ID: 16319318
PubMed ID: 16273079
PubMed ID: 16407566
Title: The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels.
PubMed ID: 16407566
PubMed ID: 16988031
Title: Kv2.1 potassium channels are retained within dynamic cell surface microdomains that are defined by a perimeter fence.
PubMed ID: 16988031
PubMed ID: 17192433
Title: Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation.
PubMed ID: 17192433
PubMed ID: 16917065
Title: Graded regulation of the Kv2.1 potassium channel by variable phosphorylation.
PubMed ID: 16917065
PubMed ID: 18690023
Title: Proteomic analyses of K(v)2.1 channel phosphorylation sites determining cell background specific differences in function.
PubMed ID: 18690023
DOI: 10.4161/chan.4388
PubMed ID: 17606996
Title: A cytoskeletal-based perimeter fence selectively corrals a sub-population of cell surface Kv2.1 channels.
PubMed ID: 17606996
DOI: 10.1242/jcs.007351
PubMed ID: 17301173
Title: K+ channel facilitation of exocytosis by dynamic interaction with syntaxin.
PubMed ID: 17301173
PubMed ID: 17379638
Title: Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons.
PubMed ID: 17379638
PubMed ID: 17360683
Title: Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1.
PubMed ID: 17360683
PubMed ID: 17965280
Title: Localization and mobility of the delayed-rectifer K+ channel Kv2.1 in adult cardiomyocytes.
PubMed ID: 17965280
PubMed ID: 19014551
Title: The Kv2.1 K+ channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situ.
PubMed ID: 19014551
PubMed ID: 18463252
Title: Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel.
PubMed ID: 18463252
PubMed ID: 18542995
Title: VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation.
PubMed ID: 18542995
PubMed ID: 18167541
Title: Direct interaction of endogenous Kv channels with syntaxin enhances exocytosis by neuroendocrine cells.
PubMed ID: 18167541
PubMed ID: 19276663
Title: Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the KV2.1 potassium channel.
PubMed ID: 19276663
PubMed ID: 19074135
Title: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
PubMed ID: 19074135
PubMed ID: 19690160
Title: Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating.
PubMed ID: 19690160
PubMed ID: 19219384
Title: Regulation of the Kv2.1 potassium channel by MinK and MiRP1.
PubMed ID: 19219384
PubMed ID: 19077057
Title: The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity.
PubMed ID: 19077057
PubMed ID: 19622611
Title: Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling.
PubMed ID: 19622611
PubMed ID: 20202934
Title: Formation of heteromeric Kv2 channels in mammalian brain neurons.
PubMed ID: 20202934
PubMed ID: 20484665
Title: Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells.
PubMed ID: 20484665
DOI: 10.1242/jcs.063719
PubMed ID: 21712386
Title: Activity-dependent phosphorylation of neuronal Kv2.1 potassium channels by CDK5.
PubMed ID: 21712386
PubMed ID: 21518833
Title: SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons.
PubMed ID: 21518833
PubMed ID: 21818121
Title: Pancreatic beta-cell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels.
PubMed ID: 21818121
DOI: 10.1038/cdd.2011.102
PubMed ID: 22411134
Title: The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
PubMed ID: 22411134
PubMed ID: 22648171
Title: Kv2.1 cell surface clusters are insertion platforms for ion channel delivery to the plasma membrane.
PubMed ID: 22648171
PubMed ID: 22673903
Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
PubMed ID: 22673903
DOI: 10.1038/ncomms1871
PubMed ID: 23878373
Title: Kv2 channels regulate firing rate in pyramidal neurons from rat sensorimotor cortex.
PubMed ID: 23878373
PubMed ID: 24569993
Title: Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.
PubMed ID: 24569993
PubMed ID: 24477962
Title: A unique ion channel clustering domain on the axon initial segment of mammalian neurons.
PubMed ID: 24477962
DOI: 10.1002/cne.23551
PubMed ID: 24928958
Title: Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents.
PubMed ID: 24928958
PubMed ID: 18004376
Title: Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
PubMed ID: 18004376
DOI: 10.1038/nature06265
PubMed ID: 20360102
Title: A gating charge transfer center in voltage sensors.
PubMed ID: 20360102
PubMed ID: 23705070
Title: Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
PubMed ID: 23705070
DOI: 10.7554/elife.00594
Sequence Information:
- Length: 857
- Mass: 95637
- Checksum: B3C5B0839AB15FD0
- Sequence:
MPAGMTKHGS RSTSSLPPEP MEIVRSKACS RRVRLNVGGL AHEVLWRTLD RLPRTRLGKL RDCNTHDSLL QVCDDYSLED NEYFFDRHPG AFTSILNFYR TGRLHMMEEM CALSFSQELD YWGIDEIYLE SCCQARYHQK KEQMNEELKR EAETLREREG EEFDNTCCAE KRKKLWDLLE KPNSSVAAKI LAIISIMFIV LSTIALSLNT LPELQSLDEF GQSTDNPQLA HVEAVCIAWF TMEYLLRFLS SPKKWKFFKG PLNAIDLLAI LPYYVTIFLT ESNKSVLQFQ NVRRVVQIFR IMRILRILKL ARHSTGLQSL GFTLRRSYNE LGLLILFLAM GIMIFSSLVF FAEKDEDDTK FKSIPASFWW ATITMTTVGY GDIYPKTLLG KIVGGLCCIA GVLVIALPIP IIVNNFSEFY KEQKRQEKAI KRREALERAK RNGSIVSMNM KDAFARSIEM MDIVVEKNGE SIAKKDKVQD NHLSPNKWKW TKRALSETSS SKSFETKEQG SPEKARSSSS PQHLNVQQLE DMYSKMAKTQ SQPILNTKEM APQSKPPEEL EMSSMPSPVA PLPARTEGVI DMRSMSSIDS FISCATDFPE ATRFSHSPLA SLSSKAGSST APEVGWRGAL GASGGRLTET NPIPETSRSG FFVESPRSSM KTNNPLKLRA LKVNFVEGDP TPLLPSLGLY HDPLRNRGGA AAAVAGLECA SLLDKPVLSP ESSIYTTASA RTPPRSPEKH TAIAFNFEAG VHHYIDTDTD DEGQLLYSVD SSPPKSLHGS TSPKFSTGAR TEKNHFESSP LPTSPKFLRP NCVYSSEGLT GKGPGAQEKC KLENHTPPDV HMLPGGGAHG STRDQSI
Genular Protein ID: 65125242
Symbol: A0A0H2UI34_RAT
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15057822
Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
PubMed ID: 15057822
DOI: 10.1038/nature02426
PubMed ID: 22673903
Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
PubMed ID: 22673903
Sequence Information:
- Length: 853
- Mass: 95281
- Checksum: 7A08998839716165
- Sequence:
MTKHGSRSTS SLPPEPMEIV RSKACSRRVR LNVGGLAHEV LWRTLDRLPR TRLGKLRDCN THDSLLQVCD DYSLEDNEYF FDRHPGAFTS ILNFYRTGRL HMMEEMCALS FSQELDYWGI DEIYLESCCQ ARYHQKKEQM NEELKREAET LREREGEEFD NTCCAEKRKK LWDLLEKPNS SVAAKILAII SIMFIVLSTI ALSLNTLPEL QSLDEFGQST DNPQLAHVEA VCIAWFTMEY LLRFLSSPKK WKFFKGPLNA IDLLAILPYY VTIFLTESNK SVLQFQNVRR VVQIFRIMRI LRILKLARHS TGLQSLGFTL RRSYNELGLL ILFLAMGIMI FSSLVFFAEK DEDDTKFKSI PASFWWATIT MTTVGYGDIY PKTLLGKIVG GLCCIAGVLV IALPIPIIVN NFSEFYKEQK RQEKAIKRRE ALERAKRNGS IVSMNMKDAF ARSIEMMDIV VEKNGESIAK KDKVQDNHLS PNKWKWTKRA LSETSSSKSF ETKEQGSPEK ARSSSSPQHL NVQQLEDMYS KMAKTQSQPI LNTKEMAPQS KPPEELEMSS MPSPVAPLPA RTEGVIDMRS MSSIDSFISC ATDFPEATRF SHSPLASLSS KAGSSTAPEV GWRGALGASG GRLTETNPIP ETSRSGFFVE SPRSSMKTNN PLKLRALKVN FVEGDPTPLL PSLGLYHDPL RNRGGAAAAV AGLECASLLD KPVLSPESSI YTTASARTPP RSPEKHTAIA FNFEAGVHHY IDTDTDDEGQ LLYSVDSSPP KSLHGSTSPK FSTGARTEKN HFESSPLPTS PKFLRPNCVY SSEGLTGKGP GAQEKCKLEN HTPPDVHMLP GGGAHGSTRD QSI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.