Plcg1 | ENSRNOG00000051490 | NCBI 25738

Details for: Plcg1

Gene ID: 25738

Symbol: Plcg1

Ensembl ID: ENSRNOG00000051490

Description: phospholipase C, gamma 1

Associated with

Calcium-dependent phospholipase c activity
(GO:0050429)
Calcium-mediated signaling
(GO:0019722)
Calcium ion binding
(GO:0005509)
Calcium ion transport
(GO:0006816)
Cell-cell junction
(GO:0005911)
Cell migration
(GO:0016477)
Cell projection
(GO:0042995)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Clathrin-coated vesicle
(GO:0030136)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Glutamate receptor binding
(GO:0035254)
Glutamatergic synapse
(GO:0098978)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Inositol trisphosphate biosynthetic process
(GO:0032959)
Inositol trisphosphate metabolic process
(GO:0032957)
Insulin receptor binding
(GO:0005158)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Lamellipodium
(GO:0030027)
Metal ion binding
(GO:0046872)
Modulation of chemical synaptic transmission
(GO:0050804)
Neurotrophin trka receptor binding
(GO:0005168)
Phosphatidylinositol-mediated signaling
(GO:0048015)
Phosphatidylinositol catabolic process
(GO:0031161)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c activity
(GO:0004629)
Phospholipid catabolic process
(GO:0009395)
Phosphoprotein binding
(GO:0051219)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Receptor tyrosine kinase binding
(GO:0030971)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to curcumin
(GO:1904643)
Response to gravity
(GO:0009629)
Response to hydrogen peroxide
(GO:0042542)
Response to organonitrogen compound
(GO:0010243)
Ruffle
(GO:0001726)
Ruffle membrane
(GO:0032587)
Schaffer collateral - ca1 synapse
(GO:0098685)
T cell receptor signaling pathway
(GO:0050852)

Other Information

Proteins

Phosphoinositide phospholipase C-gamma-1

Genular Protein ID: 1080526307

Symbol: PLCG1_RAT

Name: Phosphoinositide phospholipase C-gamma-1

UniProtKB Accession Codes:

P10686

Database IDs:

Citations:

PubMed ID: 2840660

Title: Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

PubMed ID: 2840660

DOI: 10.1073/pnas.85.15.5419

PubMed ID: 8392838

Title: Promoter region of the rat phospholipase C-gamma 1 gene.

PubMed ID: 8392838

DOI: 10.1006/bbrc.1993.1818

PubMed ID: 7518429

Title: Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.

PubMed ID: 7518429

DOI: 10.1016/s0021-9258(17)32309-8

PubMed ID: 7531435

Title: src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity.

PubMed ID: 7531435

DOI: 10.1042/bj3050745

PubMed ID: 11823862

Title: Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.

PubMed ID: 11823862

DOI: 10.1038/415541a

PubMed ID: 15252117

Title: Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis.

PubMed ID: 15252117

DOI: 10.1242/jcs.01220

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 16500902

Title: Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.

PubMed ID: 16500902

DOI: 10.1074/jbc.m600336200

Sequence Information:

Length: 1290
Mass: 148548
Checksum: BB3240C27972CE3B
Sequence:

MAGVGTPCAN GCGPSAPSEA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 
TWSRGADKIE GSIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 
SLQATSEDEV NMWIKGLTWL MEDTLQAATP LQIERWLRKQ FYSVDRNRED RISAKDLKNM 
LSQVNYRVPN MRFLRERLTD FEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLETNTLRT 
GERPELCQVS LSEFQQFLLE YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDELVT 
FLFSKENSVW NSQLDAVCPE TMNNPLSHYW ISSSHNTYLT GDQFSSESSL EAYARCLRMG 
CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH AFVASEYPVI LSIEDHCSIA 
QQRNMAQHFR KVLGDTLLTK PVDIAADGLP SPNQLKRKIL IKHKKLAEGS AYEEVPTSVM 
YSENDISNSI KNGILYLEDP VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEASG 
STELHSSEKW FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE MRLSEPVPQT 
NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN SYAISFRAEG KIKHCRVQQE 
GQTVMLGNSE FDSLVDLISY YEKHPLYRKM KLRYPINEEA LEKIGTAEPD YGALYEGRNP 
GFYVEANPMP TFKCAVKALF DYKAQREDEL TFTKSAIIQN VEKQDGGWWR GDYGGKKQLW 
FPSNYVEEMI NPAILEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 
MPSVAQWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KMMERRKKIA LELSELVVYC 
RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF LQYNRLQLSR IYPKGQRLDS 
SNYDPLPMWI CGSQLVALNF QTPDKPMQMN QALFMAGGHC GYVLQPSTMR DEAFDPFDKS 
SLRGLEPCVI CIEVLGARHL PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW 
PAKPFHFQIS NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 
ELASLLIKID IFPAKENGDL SPFSGTSLRE RASDASSQLF HVRAREGSFE ARYQQPFEDF 
RISQEHLADH FDSRERRAPR RTRVNGDNRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plcg1

Associated with

Other Information

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. PubMed ID: 2840660

Promoter region of the rat phospholipase C-gamma 1 gene. PubMed ID: 8392838

Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1. PubMed ID: 7518429

src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase C gamma 1 structure and activity. PubMed ID: 7531435

Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. PubMed ID: 11823862

Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis. PubMed ID: 15252117

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3. PubMed ID: 16500902