Associated with
Other Information
Genular Protein ID: 2824785277
Symbol: CPT1A_RAT
Name: Carnitine O-palmitoyltransferase 1, liver isoform
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8449948
Title: Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.
PubMed ID: 8449948
PubMed ID: 9136891
Title: Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris.
PubMed ID: 9136891
DOI: 10.1021/bi962875p
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17478130
Title: Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.
PubMed ID: 17478130
PubMed ID: 8348957
Title: Mature carnitine palmitoyltransferase I retains the N-terminus of the nascent protein in rat liver.
PubMed ID: 8348957
PubMed ID: 8449947
Title: Inhibitors of mitochondrial carnitine palmitoyltransferase I limit the action of proteases on the enzyme. Isolation and partial amino acid analysis of a truncated form of the rat liver isozyme.
PubMed ID: 8449947
PubMed ID: 8636126
Title: Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes.
PubMed ID: 8636126
PubMed ID: 9169604
Title: Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane.
PubMed ID: 9169604
DOI: 10.1042/bj3230711
PubMed ID: 11553629
Title: Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.
PubMed ID: 11553629
PubMed ID: 12499375
Title: Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
PubMed ID: 12499375
PubMed ID: 14711372
Title: Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.
PubMed ID: 14711372
DOI: 10.1042/bj20031373
PubMed ID: 16908527
Title: The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity.
PubMed ID: 16908527
PubMed ID: 18192268
Title: CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.
PubMed ID: 18192268
PubMed ID: 18349115
Title: A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels.
PubMed ID: 18349115
PubMed ID: 19136561
Title: Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs.
PubMed ID: 19136561
PubMed ID: 21622568
Title: Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.
PubMed ID: 21622568
PubMed ID: 21990363
Title: An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A.
PubMed ID: 21990363
PubMed ID: 24222496
Title: Comparison of the catalytic activities of three isozymes of carnitine palmitoyltransferase 1 expressed in COS7 cells.
PubMed ID: 24222496
Sequence Information:
- Length: 773
- Mass: 88125
- Checksum: 8C15594D45430CB8
- Sequence:
MAEAHQAVAF QFTVTPDGID LRLSHEALKQ ICLSGLHSWK KKFIRFKNGI ITGVFPANPS SWLIVVVGVI SSMHAKVDPS LGMIAKISRT LDTTGRMSSQ TKNIVSGVLF GTGLWVAVIM TMRYSLKVLL SYHGWMFAEH GKMSRSTKIW MAMVKVLSGR KPMLYSFQTS LPRLPVPAVK DTVSRYLESV RPLMKEEDFQ RMTALAQDFA VNLGPKLQWY LKLKSWWATN YVSDWWEEYI YLRGRGPLMV NSNYYAMEML YITPTHIQAA RAGNTIHAIL LYRRTLDREE LKPIRLLGST IPLCSAQWER LFNTSRIPGE ETDTIQHIKD SRHIVVYHRG RYFKVWLYHD GRLLRPRELE QQMQQILDDP SEPQPGEAKL AALTAADRVP WAKCRQTYFA RGKNKQSLDA VEKAAFFVTL DESEQGYREE DPEASIDSYA KSLLHGRCFD RWFDKSITFV VFKNSKIGIN AEHSWADAPV VGHLWEYVMA TDVFQLGYSE DGHCKGDTNP NIPKPTRLQW DIPGECQEVI DASLSSASLL ANDVDLHSFP FDSFGKGLIK KCRTSPDAFI QLALQLAHYK DMGKFCLTYE ASMTRLFREG RTETVRSCTM ESCNFVQAMM DPKSTAEQRL KLFKIACEKH QHLYRLAMTG AGIDRHLFCL YVVSKYLAVD SPFLKEVLSE PWRLSTSQTP QQQVELFDFE KNPDYVSCGG GFGPVADDGY GVSYIIVGEN FIHFHISSKF SSPETDSHRF GKHLRQAMMD IITLFGLTIN SKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.