SHC2 | ENSG00000129946 | NCBI 25759

Details for: SHC2

Gene ID: 25759

Symbol: SHC2

Ensembl ID: ENSG00000129946

Description: SHC adaptor protein 2

Associated with

Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signalling to erks
(R-HSA-187687)
Signalling to ras
(R-HSA-167044)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Cellular_component
(GO:0005575)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor tyrosine kinase binding
(GO:0030971)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

SHC-transforming protein 2

Genular Protein ID: 2944276500

Symbol: SHC2_HUMAN

Name: SHC-transforming protein 2

UniProtKB Accession Codes:

P98077 O60230 Q9NPL5 Q9UCX4

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9507002

Title: N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.

PubMed ID: 9507002

DOI: 10.1074/jbc.273.12.6960

PubMed ID: 8760305

Title: A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.

PubMed ID: 8760305

PubMed ID: 7527937

Title: An alternative to SH2 domains for binding tyrosine-phosphorylated proteins.

PubMed ID: 7527937

DOI: 10.1126/science.7527937

PubMed ID: 12006576

Title: ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.

PubMed ID: 12006576

DOI: 10.1074/jbc.m111659200

PubMed ID: 15851471

Title: Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.

PubMed ID: 15851471

DOI: 10.1074/jbc.m413411200

Sequence Information:

Length: 582
Mass: 61916
Checksum: F640AC298DA37B68
Sequence:

MTQGPGGRAP PAPPAPPEPE APTTFCALLP RMPQWKFAAP GGFLGRGPAA ARAAGASGGA 
DPQPEPAGPG GVPALAAAVL GACEPRCAAP CPLPALSRCR GAGSRGSRGG RGAAGSGDAA 
AAAEWIRKGS FIHKPAHGWL HPDARVLGPG VSYVVRYMGC IEVLRSMRSL DFNTRTQVTR 
EAINRLHEAV PGVRGSWKKK APNKALASVL GKSNLRFAGM SISIHISTDG LSLSVPATRQ 
VIANHHMPSI SFASGGDTDM TDYVAYVAKD PINQRACHIL ECCEGLAQSI ISTVGQAFEL 
RFKQYLHSPP KVALPPERLA GPEESAWGDE EDSLEHNYYN SIPGKEPPLG GLVDSRLALT 
QPCALTALDQ GPSPSLRDAC SLPWDVGSTG TAPPGDGYVQ ADARGPPDHE EHLYVNTQGL 
DAPEPEDSPK KDLFDMRPFE DALKLHECSV AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE 
QLRQEPWYHG RMSRRAAERM LRADGDFLVR DSVTNPGQYV LTGMHAGQPK HLLLVDPEGV 
VRTKDVLFES ISHLIDHHLQ NGQPIVAAES ELHLRGVVSR EP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SHC2

Associated with

Other Information

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. PubMed ID: 9507002

A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. PubMed ID: 8760305

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. PubMed ID: 7527937

ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. PubMed ID: 12006576