FBXO7 | ENSG00000100225 | NCBI 25793

Details for: FBXO7

Gene ID: 25793

Symbol: FBXO7

Ensembl ID: ENSG00000100225

Description: F-box protein 7

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Autophagy of mitochondrion
(GO:0000422)
Classical lewy body
(GO:0097414)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glial cytoplasmic inclusion
(GO:0097409)
Lewy body core
(GO:1990037)
Lewy body corona
(GO:1990038)
Lewy neurite
(GO:0097462)
Lymphocyte differentiation
(GO:0030098)
Mitochondrion
(GO:0005739)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of lymphocyte differentiation
(GO:0045620)
Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903377)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of autophagy of mitochondrion
(GO:1903599)
Positive regulation of mitophagy
(GO:1901526)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein k48-linked ubiquitination
(GO:0070936)
Protein kinase binding
(GO:0019901)
Protein targeting to mitochondrion
(GO:0006626)
Protein ubiquitination
(GO:0016567)
Regulation of locomotion
(GO:0040012)
Regulation of neuron projection development
(GO:0010975)
Regulation of protein stability
(GO:0031647)
Scf ubiquitin ligase complex
(GO:0019005)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

F-box only protein 7

Genular Protein ID: 2493068689

Symbol: FBX7_HUMAN

Name: F-box only protein 7

UniProtKB Accession Codes:

Q9Y3I1 B4DNB3 B4DWX5 Q5TGC4 Q5TI86 Q96HM6 Q9UF21 Q9UKT2

Database IDs:

Citations:

PubMed ID: 10945468

Title: cDNA cloning and expression analysis of new members of the mammalian F-box protein family.

PubMed ID: 10945468

DOI: 10.1006/geno.2000.6211

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531035

Title: Identification of a family of human F-box proteins.

PubMed ID: 10531035

DOI: 10.1016/s0960-9822(00)80020-2

PubMed ID: 12527899

Title: Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma.

PubMed ID: 12527899

DOI: 10.1038/sj.onc.1206129

PubMed ID: 15145941

Title: Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.

PubMed ID: 15145941

DOI: 10.1074/jbc.m404950200

PubMed ID: 16096642

Title: Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

PubMed ID: 16096642

DOI: 10.1038/sj.emboj.7600775

PubMed ID: 16510124

Title: The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination.

PubMed ID: 16510124

DOI: 10.1016/j.bbrc.2006.02.061

PubMed ID: 18495667

Title: Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor.

PubMed ID: 18495667

DOI: 10.1074/jbc.m709900200

PubMed ID: 22212761

Title: Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

PubMed ID: 22212761

DOI: 10.1111/j.1582-4934.2012.01524.x

PubMed ID: 23933751

Title: The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

PubMed ID: 23933751

DOI: 10.1038/nn.3489

PubMed ID: 33010352

Title: The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappaB signaling pathway.

PubMed ID: 33010352

DOI: 10.1016/j.bbagen.2020.129754

PubMed ID: 34791250

Title: The F-box protein, FBXO7, is required to maintain chromosome stability in humans.

PubMed ID: 34791250

DOI: 10.1093/hmg/ddab330

PubMed ID: 36646384

Title: E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide.

PubMed ID: 36646384

DOI: 10.1016/j.jbc.2023.102909

PubMed ID: 24419388

Title: Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction.

PubMed ID: 24419388

DOI: 10.1107/s1399004713025820

PubMed ID: 18513678

Title: Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.

PubMed ID: 18513678

DOI: 10.1016/j.ajhg.2008.05.005

PubMed ID: 20853184

Title: Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability.

PubMed ID: 20853184

DOI: 10.1007/s10048-010-0259-0

PubMed ID: 32892229

Title: Segregation of ATP10B variants in families with autosomal recessive parkinsonism.

PubMed ID: 32892229

DOI: 10.1007/s00401-020-02219-6

Sequence Information:

Length: 522
Mass: 58503
Checksum: C4E5E70A0747287A
Sequence:

MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL NYKDPLTGDE 
ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN NEQPSLATSS NQTSMQDEQP 
SDSFQGQAAQ SGVWNDDSML GPSQNFEAES IQDNAHMAEG TGFYPSEPML CSESVEGQVP 
HSLETLYQSA DCSDANDALI VLIHLLMLES GYIPQGTEAK ALSMPEKWKL SGVYKLQYMH 
PLCEGSSATL TCVPLGNLIV VNATLKINNE IRSVKRLQLL PESFICKEKL GENVANIYKD 
LQKLSRLFKD QLVYPLLAFT RQALNLPDVF GLVVLPLELK LRIFRLLDVR SVLSLSAVCR 
DLFTASNDPL LWRFLYLRDF RDNTVRVQDT DWKELYRKRH IQRKESPKGR FVMLLPSSTH 
TIPFYPNPLH PRPFPSSRLP PGIIGGEYDQ RPTLPYVGDP ISSLIPGPGE TPSQFPPLRP 
RFDPVGPLPG PNPILPGRGG PNDRFPFRPS RGRPTDGRLS FM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FBXO7

Associated with

Other Information

cDNA cloning and expression analysis of new members of the mammalian F-box protein family. PubMed ID: 10945468

Reevaluating human gene annotation: a second-generation analysis of chromosome 22. PubMed ID: 12529303

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a family of human F-box proteins. PubMed ID: 10531035

Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. PubMed ID: 12527899

Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. PubMed ID: 15145941

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. PubMed ID: 16096642

The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. PubMed ID: 16510124

Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. PubMed ID: 18495667

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling. PubMed ID: 22212761

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. PubMed ID: 23933751

The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-kappaB signaling pathway. PubMed ID: 33010352

The F-box protein, FBXO7, is required to maintain chromosome stability in humans. PubMed ID: 34791250

E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide. PubMed ID: 36646384

Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction. PubMed ID: 24419388

Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays. PubMed ID: 18513678

Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability. PubMed ID: 20853184

Segregation of ATP10B variants in families with autosomal recessive parkinsonism. PubMed ID: 32892229