Details for: QPCT

Gene ID: 25797

Symbol: QPCT

Ensembl ID: ENSG00000115828

Description: glutaminyl-peptide cyclotransferase

Associated with

Other Information

Genular Protein ID: 604906942

Symbol: QPCT_HUMAN

Name: Glutaminyl-peptide cyclotransferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7999256

Title: Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase.

PubMed ID: 7999256

DOI: 10.1677/jme.0.0130077

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15063747

Title: Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.

PubMed ID: 15063747

DOI: 10.1016/s0014-5793(04)00300-x

PubMed ID: 18486145

Title: Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.

PubMed ID: 18486145

DOI: 10.1016/j.jmb.2008.03.078

PubMed ID: 16135565

Title: Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.

PubMed ID: 16135565

DOI: 10.1073/pnas.0504184102

PubMed ID: 18072935

Title: A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.

PubMed ID: 18072935

DOI: 10.1042/bj20071073

PubMed ID: 21671571

Title: Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

PubMed ID: 21671571

DOI: 10.1021/bi200249h

PubMed ID: 21288892

Title: Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding.

PubMed ID: 21288892

DOI: 10.1074/jbc.m110.208595

Sequence Information:

  • Length: 361
  • Mass: 40877
  • Checksum: 32C26041BCF5ED75
  • Sequence:
  • MAGGRHRRVV GTLHLLLLVA ALPWASRGVS PSASAWPEEK NYHQPAILNS SALRQIAEGT 
    SISEMWQNDL QPLLIERYPG SPGSYAARQH IMQRIQRLQA DWVLEIDTFL SQTPYGYRSF 
    SNIISTLNPT AKRHLVLACH YDSKYFSHWN NRVFVGATDS AVPCAMMLEL ARALDKKLLS 
    LKTVSDSKPD LSLQLIFFDG EEAFLHWSPQ DSLYGSRHLA AKMASTPHPP GARGTSQLHG 
    MDLLVLLDLI GAPNPTFPNF FPNSARWFER LQAIEHELHE LGLLKDHSLE GRYFQNYSYG 
    GVIQDDHIPF LRRGVPVLHL IPSPFPEVWH TMDDNEENLD ESTIDNLNKI LQVFVLEYLH 
    L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.