Details for: AMBN

Gene ID: 258

Symbol: AMBN

Ensembl ID: ENSG00000178522

Description: ameloblastin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 4.6707
    Cell Significance Index: 64.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5241
    Cell Significance Index: 12.7000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.4742
    Cell Significance Index: 6.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3971
    Cell Significance Index: 5.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.3884
    Cell Significance Index: -0.8500
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.3847
    Cell Significance Index: 2.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3830
    Cell Significance Index: 10.0700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.3342
    Cell Significance Index: 2.4300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3057
    Cell Significance Index: 4.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2144
    Cell Significance Index: 3.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1861
    Cell Significance Index: 3.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1055
    Cell Significance Index: 1.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0916
    Cell Significance Index: 2.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0671
    Cell Significance Index: 0.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0438
    Cell Significance Index: 0.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0356
    Cell Significance Index: 4.5700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0253
    Cell Significance Index: 0.8000
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.0218
    Cell Significance Index: 0.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0194
    Cell Significance Index: 3.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0165
    Cell Significance Index: 0.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0128
    Cell Significance Index: 0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0096
    Cell Significance Index: 3.4600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0042
    Cell Significance Index: 0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0034
    Cell Significance Index: 0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0031
    Cell Significance Index: 4.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0028
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0026
    Cell Significance Index: 0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0024
    Cell Significance Index: 4.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0014
    Cell Significance Index: 1.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0001
    Cell Significance Index: 0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0009
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0022
    Cell Significance Index: -1.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0057
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0060
    Cell Significance Index: -1.2700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0080
    Cell Significance Index: -1.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0091
    Cell Significance Index: -0.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0102
    Cell Significance Index: -1.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0124
    Cell Significance Index: -1.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0148
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0152
    Cell Significance Index: -1.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0157
    Cell Significance Index: -0.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0174
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0177
    Cell Significance Index: -0.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0211
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0218
    Cell Significance Index: -0.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0231
    Cell Significance Index: -0.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0232
    Cell Significance Index: -1.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0250
    Cell Significance Index: -0.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0253
    Cell Significance Index: -1.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0254
    Cell Significance Index: -0.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0257
    Cell Significance Index: -0.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0296
    Cell Significance Index: -1.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0304
    Cell Significance Index: -0.3900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0311
    Cell Significance Index: -0.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0320
    Cell Significance Index: -0.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0323
    Cell Significance Index: -0.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0344
    Cell Significance Index: -0.8600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0361
    Cell Significance Index: -0.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0363
    Cell Significance Index: -0.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0377
    Cell Significance Index: -1.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0378
    Cell Significance Index: -0.9400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0391
    Cell Significance Index: -0.4100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0403
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0406
    Cell Significance Index: -0.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0413
    Cell Significance Index: -0.9900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0413
    Cell Significance Index: -0.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0417
    Cell Significance Index: -0.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0421
    Cell Significance Index: -1.4800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0431
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0438
    Cell Significance Index: -0.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0438
    Cell Significance Index: -1.2500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0441
    Cell Significance Index: -0.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0449
    Cell Significance Index: -0.4700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0455
    Cell Significance Index: -0.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0465
    Cell Significance Index: -0.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0466
    Cell Significance Index: -0.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0471
    Cell Significance Index: -1.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0476
    Cell Significance Index: -0.8000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0480
    Cell Significance Index: -0.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0486
    Cell Significance Index: -0.9700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0492
    Cell Significance Index: -0.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0494
    Cell Significance Index: -1.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0501
    Cell Significance Index: -0.9800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0505
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0525
    Cell Significance Index: -0.7800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0552
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Ameloblastin is a secreted protein that exhibits a unique molecular structure, comprising 10 cysteine residues and a highly conserved N-terminal domain. Its expression is observed in cells of the hematopoietic system, including erythrocytes, megakaryocytes, and hematopoietic stem cells. AMBN is also expressed in neuronal cells, including retinal cone cells and cerebral cortex GABAergic interneurons, suggesting a broader role in the nervous system. Notably, AMBN is also found in cells of the dental epithelium, where it may play a crucial role in tooth development and biomineralization. **Pathways and Functions:** The AMBN protein is involved in various cellular processes, including biomineralization, cell adhesion, and signal transduction. Biomineralization, the process by which cells deposit minerals to form hard tissues, is a critical aspect of tooth development and bone formation. AMBN has been shown to interact with other proteins involved in biomineralization, such as osteopontin and amelogenin, suggesting a key role in regulating the mineralization process. Additionally, AMBN has been implicated in cell adhesion, where it interacts with integrins and other adhesion molecules to regulate cell-cell interactions. **Clinical Significance:** The AMBN gene has been associated with various diseases, including periodontal disease, where it is thought to play a role in the regulation of immune responses and tissue remodeling. Mutations in the AMBN gene have also been linked to tooth development disorders, such as ameloblastoma, a rare tumor of the dental epithelium. Furthermore, AMBN has been shown to interact with other proteins involved in the regulation of insulin-like growth factor (IGF) transport and uptake by IGF binding proteins (IGFBPs), suggesting a potential role in metabolic regulation. In conclusion, AMBN is a multifunctional protein with a complex expression profile and a range of cellular functions. While its exact mechanisms of action remain poorly understood, recent studies have highlighted its potential role in immune regulation, tooth development, and metabolic regulation. Further research is needed to fully elucidate the functional significance of AMBN and its potential therapeutic applications. **Signaling Pathways:** The AMBN protein is involved in the following signaling pathways: 1. **Biomineralization:** AMBN interacts with osteopontin and amelogenin to regulate mineralization. 2. **Cell adhesion:** AMBN interacts with integrins and other adhesion molecules to regulate cell-cell interactions. 3. **Signal transduction:** AMBN interacts with various signaling proteins to regulate cellular responses. **Regulated by:** The AMBN protein is regulated by various cellular processes, including: 1. **Protein phosphorylation:** AMBN is phosphorylated by various kinases, including PKA and PKC. 2. **Post-translational modification:** AMBN is modified by various enzymes, including glycosylation and ubiquitination. **Regulates:** 1. **Cell proliferation:** AMBN regulates cell proliferation by interacting with cell cycle regulators. 2. **Cell differentiation:** AMBN regulates cell differentiation by interacting with transcription factors. 3. **Tissue remodeling:** AMBN regulates tissue remodeling by interacting with matrix metalloproteinases.

Genular Protein ID: 397126073

Symbol: AMBN_HUMAN

Name: Ameloblastin

UniProtKB Accession Codes:

Q9NP70 Q3B862 Q9H2X1 Q9H4L1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11054529

Title: Cloning and characterization of the human ameloblastin gene.

PubMed ID: 11054529

DOI: 10.1016/s0378-1119(00)00379-6

PubMed ID: 10946765

Title: Cloning, characterization and immunolocalization of human ameloblastin.

PubMed ID: 10946765

DOI: 10.1034/j.1600-0722.2000.108004303.x

PubMed ID: 11330937

Title: Human ameloblastin gene: genomic organization and mutation analysis in amelogenesis imperfecta patients.

PubMed ID: 11330937

DOI: 10.1034/j.1600-0722.2001.00979.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24858907

Title: Deletion of ameloblastin exon 6 is associated with amelogenesis imperfecta.

PubMed ID: 24858907

DOI: 10.1093/hmg/ddu247

Sequence Information:

  • Length: 447
  • Mass: 48283
  • Checksum: D5CAFAA76B55758C
  • Sequence:
    • MSASKIPLFK MKDLILILCL LEMSFAVPFF PQQSGTPGMA SLSLETMRQL GSLQRLNTLS 
QYSRYGFGKS FNSLWMHGLL PPHSSLPWMR PREHETQQYE YSLPVHPPPL PSQPSLKPQQ 
PGLKPFLQSA AATTNQATAL KEALQPPIHL GHLPLQEGEL PLVQQQVAPS DKPPKPELPG 
VDFADPQGPS LPGMDFPDPQ GPSLPGLDFA DPQGSTIFQI ARLISHGPMP QNKQSPLYPG 
MLYVPFGANQ LNAPARLGIM SSEEVAGGRE DPMAYGAMFP GFGGMRPGFE GMPHNPAMGG 
DFTLEFDSPV AATKGPENEE GGAQGSPMPE ANPDNLENPA FLTELEPAPH AGLLALPKDD 
IPGLPRSPSG KMKGLPSVTP AAADPLMTPE LADVYRTYDA DMTTSVDFQE EATMDTTMAP 
NSLQTSMPGN KAQEPEMMHD AWHFQEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.