SLC39A6 | ENSG00000141424 | NCBI 25800

Details for: SLC39A6

Gene ID: 25800

Symbol: SLC39A6

Ensembl ID: ENSG00000141424

Description: solute carrier family 39 member 6

Associated with

Metal ion slc transporters
(R-HSA-425410)
Slc-mediated transmembrane transport
(R-HSA-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-HSA-425366)
Transport of small molecules
(R-HSA-382551)
Zinc influx into cells by the slc39 gene family
(R-HSA-442380)
Zinc transporters
(R-HSA-435354)
Apical plasma membrane
(GO:0016324)
Bicarbonate transport
(GO:0015701)
Cell surface
(GO:0009986)
Endoplasmic reticulum
(GO:0005783)
Epithelial to mesenchymal transition
(GO:0001837)
Intracellular zinc ion homeostasis
(GO:0006882)
Lamellipodium membrane
(GO:0031258)
Lymphocyte activation
(GO:0046649)
Membrane raft
(GO:0045121)
Monoatomic cation:bicarbonate symporter activity
(GO:0140410)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
T cell receptor signaling pathway
(GO:0050852)
Zinc ion import across plasma membrane
(GO:0071578)
Zinc ion transmembrane transport
(GO:0071577)
Zinc ion transmembrane transporter activity
(GO:0005385)

Other Information

Proteins

Estrogen-regulated protein LIV-1

Genular Protein ID: 1007288394

Symbol: S39A6_HUMAN

Name: Estrogen-regulated protein LIV-1

UniProtKB Accession Codes:

Q13433 B4DR49 B4E224 Q8IXR3 Q96HP5

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2903103

Title: Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line.

PubMed ID: 2903103

DOI: 10.1016/0303-7207(88)90105-0

PubMed ID: 12839489

Title: Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.

PubMed ID: 12839489

DOI: 10.1042/bj20030478

PubMed ID: 18272141

Title: Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions.

PubMed ID: 18272141

DOI: 10.1016/j.brainres.2008.01.015

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21422171

Title: Regulation of T cell receptor signaling by activation-induced zinc influx.

PubMed ID: 21422171

DOI: 10.1084/jem.20100031

PubMed ID: 23919497

Title: A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3).

PubMed ID: 23919497

DOI: 10.1042/bj20130483

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25143461

Title: Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.

PubMed ID: 25143461

DOI: 10.1093/molehr/gau066

PubMed ID: 27274087

Title: Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration.

PubMed ID: 27274087

DOI: 10.1042/bcj20160388

PubMed ID: 30552163

Title: Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery.

PubMed ID: 30552163

DOI: 10.4049/jimmunol.1800689

PubMed ID: 32797246

Title: The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.

PubMed ID: 32797246

DOI: 10.1007/s00018-020-03616-6

PubMed ID: 34394081

Title: Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse.

PubMed ID: 34394081

DOI: 10.3389/fimmu.2021.687367

Sequence Information:

Length: 755
Mass: 85047
Checksum: 8BC1D02CA116DD25
Sequence:

MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL 
FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSEH 
EHHSDHDHHS HHNHAASGKN KRKALCPDHD SDSSGKDPRN SQGKGAHRPE HASGRRNVKD 
SVSASEVTST VYNTVSEGTH FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT 
NESVSEPRKG FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA 
RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN RVFFKFLLSF 
LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR GPLFSHLSSQ NIEESAYFDS 
TWKGLTALGG LYFMFLVEHV LTLIKQFKDK KKKNQKKPEN DDDVEIKKQL SKYESQLSTN 
EEKVDTDDRT EGYLRADSQE PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC 
HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI 
MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA GMTVKQAVLY 
NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV ALVDMVPEML HNDASDHGCS 
RWGYFFLQNA GMLLGFGIML LISIFEHKIV FRINF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLC39A6

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line. PubMed ID: 2903103

Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. PubMed ID: 12839489

Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions. PubMed ID: 18272141

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Regulation of T cell receptor signaling by activation-induced zinc influx. PubMed ID: 21422171

A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3). PubMed ID: 23919497

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition. PubMed ID: 25143461

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. PubMed ID: 27274087

Zip6 Transporter Is an Essential Component of the Lymphocyte Activation Machinery. PubMed ID: 30552163

The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis. PubMed ID: 32797246

Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse. PubMed ID: 34394081