Details for: ARIH1
Associated with
Other Information
Genular Protein ID: 659765028
Symbol: ARI1_HUMAN
Name: E3 ubiquitin-protein ligase ARIH1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10521492
Title: The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.
PubMed ID: 10521492
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10880484
Title: Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.
PubMed ID: 10880484
PubMed ID: 11124703
Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.
PubMed ID: 11124703
DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h
PubMed ID: 11124525
Title: Characterisation of the human and mouse orthologues of the Drosophila ariadne gene.
PubMed ID: 11124525
DOI: 10.1159/000056780
PubMed ID: 11278816
Title: Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.
PubMed ID: 11278816
PubMed ID: 14623119
Title: Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.
PubMed ID: 14623119
PubMed ID: 17289916
Title: ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.
PubMed ID: 17289916
DOI: 10.1101/gad.1521607
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21532592
Title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
PubMed ID: 21532592
DOI: 10.1038/nature09966
PubMed ID: 21590270
Title: The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies.
PubMed ID: 21590270
PubMed ID: 24076655
Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
PubMed ID: 24076655
PubMed ID: 23059369
Title: Human homolog of drosophila ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.
PubMed ID: 23059369
PubMed ID: 25624349
Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
PubMed ID: 25624349
DOI: 10.1128/mcb.01152-14
PubMed ID: 27565346
Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.
PubMed ID: 27565346
PubMed ID: 29689197
Title: Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.
PubMed ID: 29689197
PubMed ID: 15236971
Title: Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING.
PubMed ID: 15236971
PubMed ID: 24058416
Title: Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.
PubMed ID: 24058416
PubMed ID: 23707686
Title: Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.
PubMed ID: 23707686
Sequence Information:
- Length: 557
- Mass: 64118
- Checksum: DFFF8965DAB41DC8
- Sequence:
MDSDEGYNYE FDEDEECSEE DSGAEEEEDE DDDEPDDDTL DLGEVELVEP GLGVGGERDG LLCGETGGGG GSALGPGGGG GGGGGGGGGG PGHEQEEDYR YEVLTAEQIL QHMVECIREV NEVIQNPATI TRILLSHFNW DKEKLMERYF DGNLEKLFAE CHVINPSKKS RTRQMNTRSS AQDMPCQICY LNYPNSYFTG LECGHKFCMQ CWSEYLTTKI MEEGMGQTIS CPAHGCDILV DDNTVMRLIT DSKVKLKYQH LITNSFVECN RLLKWCPAPD CHHVVKVQYP DAKPVRCKCG RQFCFNCGEN WHDPVKCKWL KKWIKKCDDD SETSNWIAAN TKECPKCHVT IEKDGGCNHM VCRNQNCKAE FCWVCLGPWE PHGSAWYNCN RYNEDDAKAA RDAQERSRAA LQRYLFYCNR YMNHMQSLRF EHKLYAQVKQ KMEEMQQHNM SWIEVQFLKK AVDVLCQCRA TLMYTYVFAF YLKKNNQSII FENNQADLEN ATEVLSGYLE RDISQDSLQD IKQKVQDKYR YCESRRRVLL QHVHEGYEKD LWEYIED
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.