Details for: BACE2
Associated with
Other Information
Genular Protein ID: 2394507627
Symbol: BACE2_HUMAN
Name: Beta-secretase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10591213
Title: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
PubMed ID: 10591213
DOI: 10.1038/990107
PubMed ID: 10838186
Title: Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines.
PubMed ID: 10838186
PubMed ID: 10965118
Title: A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase.
PubMed ID: 10965118
DOI: 10.1159/000015608
PubMed ID: 10683441
Title: The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region.
PubMed ID: 10683441
PubMed ID: 10749877
Title: Expression analysis of BACE2 in brain and peripheral tissues.
PubMed ID: 10749877
PubMed ID: 11083922
Title: ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
PubMed ID: 11083922
PubMed ID: 10677483
Title: Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
PubMed ID: 10677483
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15857888
Title: Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
PubMed ID: 15857888
PubMed ID: 11423558
Title: BACE2 functions as an alternative alpha-secretase in cells.
PubMed ID: 11423558
PubMed ID: 16816112
Title: BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.
PubMed ID: 16816112
PubMed ID: 16305800
Title: Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
PubMed ID: 16305800
PubMed ID: 11316808
Title: Prodomain processing of Asp1 (BACE2) is autocatalytic.
PubMed ID: 11316808
PubMed ID: 16965550
Title: Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
PubMed ID: 16965550
PubMed ID: 21907142
Title: Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass.
PubMed ID: 21907142
PubMed ID: 23754390
Title: BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.
PubMed ID: 23754390
Sequence Information:
- Length: 518
- Mass: 56180
- Checksum: 2E903150823760D3
- Sequence:
MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET PWSYFPKISI YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP STNALVIGAT VMEGFYVIFD RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI VSYALMSVCG AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.