Details for: FBXL2

Gene ID: 25827

Symbol: FBXL2

Ensembl ID: ENSG00000153558

Description: F-box and leucine rich repeat protein 2

Associated with

Other Information

Genular Protein ID: 3804565217

Symbol: FBXL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10531035

Title: Identification of a family of human F-box proteins.

PubMed ID: 10531035

DOI: 10.1016/s0960-9822(00)80020-2

PubMed ID: 10531037

Title: A family of mammalian F-box proteins.

PubMed ID: 10531037

DOI: 10.1016/s0960-9822(00)80021-4

PubMed ID: 10945468

Title: cDNA cloning and expression analysis of new members of the mammalian F-box protein family.

PubMed ID: 10945468

DOI: 10.1006/geno.2000.6211

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15893726

Title: Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication.

PubMed ID: 15893726

DOI: 10.1016/j.molcel.2005.04.004

PubMed ID: 22323446

Title: F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation.

PubMed ID: 22323446

DOI: 10.1182/blood-2011-06-358911

PubMed ID: 22020328

Title: F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest.

PubMed ID: 22020328

DOI: 10.1038/onc.2011.432

PubMed ID: 23604317

Title: FBXL2- and PTPL1-mediated degradation of p110-free p85beta regulatory subunit controls the PI(3)K signalling cascade.

PubMed ID: 23604317

DOI: 10.1038/ncb2731

PubMed ID: 26037928

Title: Lipopolysaccharide primes the NALP3 inflammasome by inhibiting its ubiquitination and degradation mediated by the SCFFBXL2 E3 ligase.

PubMed ID: 26037928

DOI: 10.1074/jbc.m115.645549

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 423
  • Mass: 47062
  • Checksum: 61938E434618BA3D
  • Sequence:
  • MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF 
    QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS 
    TCYSLSRFCS KLKHLDLTSC VSITNSSLKG ISEGCRNLEY LNLSWCDQIT KDGIEALVRG 
    CRGLKALLLR GCTQLEDEAL KHIQNYCHEL VSLNLQSCSR ITDEGVVQIC RGCHRLQALC 
    LSGCSNLTDA SLTALGLNCP RLQILEAARC SHLTDAGFTL LARNCHELEK MDLEECILIT 
    DSTLIQLSIH CPKLQALSLS HCELITDDGI LHLSNSTCGH ERLRVLELDN CLLITDVALE 
    HLENCRGLER LELYDCQQVT RAGIKRMRAQ LPHVKVHAYF APVTPPTAVA GSGQRLCRCC 
    VIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.