TXN2 | ENSG00000100348 | NCBI 25828

Details for: TXN2

Gene ID: 25828

Symbol: TXN2

Ensembl ID: ENSG00000100348

Description: thioredoxin 2

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Degradation of cysteine and homocysteine
(R-HSA-1614558)
Detoxification of reactive oxygen species
(R-HSA-3299685)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Sulfur amino acid metabolism
(R-HSA-1614635)
Cell redox homeostasis
(GO:0045454)
Cellular response to nutrient levels
(GO:0031669)
Dendrite
(GO:0030425)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Neuronal cell body
(GO:0043025)
Nucleolus
(GO:0005730)
Peptide-methionine (r)-s-oxide reductase activity
(GO:0033743)
Peptide-methionine (s)-s-oxide reductase activity
(GO:0008113)
Protein-containing complex binding
(GO:0044877)
Protein-disulfide reductase activity
(GO:0015035)
Protein binding
(GO:0005515)
Response to axon injury
(GO:0048678)
Response to glucose
(GO:0009749)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

Thioredoxin, mitochondrial

Genular Protein ID: 2160340132

Symbol: THIOM_HUMAN

Name: Thioredoxin, mitochondrial

UniProtKB Accession Codes:

Q99757 Q5JZA0 Q6FH60 Q9UH29

Database IDs:

Citations:

PubMed ID: 12032145

Title: Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells.

PubMed ID: 12032145

DOI: 10.1074/jbc.m202026200

PubMed ID: 12080052

Title: Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.

PubMed ID: 12080052

DOI: 10.1074/jbc.m203036200

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26626369

Title: Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.

PubMed ID: 26626369

DOI: 10.1093/brain/awv350

PubMed ID: 16195549

Title: Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2.

PubMed ID: 16195549

DOI: 10.1110/ps.051632905

Sequence Information:

Length: 166
Mass: 18383
Checksum: C4CA8CDAD485D499
Sequence:

MAQRLLLRRF LASVISRKPS QGQWPPLTSR ALQTPQCSPG GLTVTPNPAR TIYTTRISLT 
TFNIQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL EKMVAKQHGK VVMAKVDIDD 
HTDLAIEYEV SAVPTVLAMK NGDVVDKFVG IKDEDQLEAF LKKLIG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TXN2

Associated with

Other Information

Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. PubMed ID: 12032145

Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. PubMed ID: 12080052

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration. PubMed ID: 26626369

Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2. PubMed ID: 16195549