Details for: ASF1A

Gene ID: 25842

Symbol: ASF1A

Ensembl ID: ENSG00000111875

Description: anti-silencing function 1A histone chaperone

Associated with

Other Information

Genular Protein ID: 4096072753

Symbol: ASF1A_HUMAN

Name: Histone chaperone ASF1A

UniProtKB Accession Codes:

Q9Y294 Q6IA08 Q9P014

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 17 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10759893

Title: A human homologue of yeast anti-silencing factor has histone chaperone activity.

PubMed ID: 10759893

DOI: 10.1046/j.1365-2443.2000.00319.x

PubMed ID: 11470414

Title: Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.

PubMed ID: 11470414

DOI: 10.1016/s0960-9822(01)00298-6

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11897662

Title: Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway.

PubMed ID: 11897662

DOI: 10.1093/embo-reports/kvf068

PubMed ID: 12093919

Title: Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.

PubMed ID: 12093919

DOI: 10.1073/pnas.142627899

PubMed ID: 14680630

Title: Structure and function of the conserved core of histone deposition protein Asf1.

PubMed ID: 14680630

DOI: 10.1016/j.cub.2003.11.027

PubMed ID: 12842904

Title: Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis.

PubMed ID: 12842904

DOI: 10.1074/jbc.m303549200

PubMed ID: 14718166

Title: Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.

PubMed ID: 14718166

DOI: 10.1016/s0092-8674(03)01064-x

PubMed ID: 15621527

Title: Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.

PubMed ID: 15621527

DOI: 10.1016/j.devcel.2004.10.019

PubMed ID: 16151251

Title: Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones.

PubMed ID: 16151251

DOI: 10.1128/ec.4.9.1583-1590.2005

PubMed ID: 15664198

Title: Human Asf1 regulates the flow of S phase histones during replicational stress.

PubMed ID: 15664198

DOI: 10.1016/j.molcel.2004.12.018

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19029251

Title: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.

PubMed ID: 19029251

DOI: 10.1128/mcb.01047-08

PubMed ID: 20016786

Title: Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.

PubMed ID: 20016786

DOI: 10.1371/journal.pone.0008328

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454524

Title: Sequential establishment of marks on soluble histones H3 and H4.

PubMed ID: 21454524

DOI: 10.1074/jbc.m111.223453

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22407294

Title: Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply.

PubMed ID: 22407294

DOI: 10.1038/emboj.2012.55

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24616510

Title: Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.

PubMed ID: 24616510

DOI: 10.1073/pnas.1319122111

PubMed ID: 29408485

Title: Integrative structural investigation on the architecture of human Importin4_Histone H3/H4_Asf1a complex and its histone H3 tail binding.

PubMed ID: 29408485

DOI: 10.1016/j.jmb.2018.01.015

PubMed ID: 29478807

Title: The histone chaperones ASF1 and CAF-1 promote MMS22L-TONSL-mediated Rad51 loading onto ssDNA during homologous recombination in human cells.

PubMed ID: 29478807

DOI: 10.1016/j.molcel.2018.01.031

PubMed ID: 33857403

Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.

PubMed ID: 33857403

DOI: 10.1016/j.molcel.2021.03.041

PubMed ID: 15840725

Title: Structural basis for the interaction of Asf1 with histone H3 and its functional implications.

PubMed ID: 15840725

DOI: 10.1073/pnas.0500149102

PubMed ID: 16980972

Title: Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.

PubMed ID: 16980972

DOI: 10.1038/nsmb1147

PubMed ID: 35136069

Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.

PubMed ID: 35136069

DOI: 10.1038/s41467-022-28427-0

Sequence Information:

  • Length: 204
  • Mass: 22969
  • Checksum: 9819D531D3A9FC68
  • Sequence:
    • MAKVQVNNVV VLDNPSPFYN PFQFEITFEC IEDLSEDLEW KIIYVGSAES EEYDQVLDSV 
LVGPVPAGRH MFVFQADAPN PGLIPDADAV GVTVVLITCT YRGQEFIRVG YYVNNEYTET 
ELRENPPVKP DFSKLQRNIL ASNPRVTRFH INWEDNTEKL EDAESSNPNL QSLLSTDALP 
SASKGWSTSE NSLNVMLESH MDCM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.