Details for: PRKD2

Gene ID: 25865

Symbol: PRKD2

Ensembl ID: ENSG00000105287

Description: protein kinase D2

Associated with

  • Metabolism
    (R-HSA-1430728)
  • Metabolism of lipids
    (R-HSA-556833)
  • Sphingolipid de novo biosynthesis
    (R-HSA-1660661)
  • Sphingolipid metabolism
    (R-HSA-428157)
  • Adaptive immune response
    (GO:0002250)
  • Angiogenesis
    (GO:0001525)
  • Atp binding
    (GO:0005524)
  • Cell adhesion
    (GO:0007155)
  • Cellular response to vascular endothelial growth factor stimulus
    (GO:0035924)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Diacylglycerol-dependent serine/threonine kinase activity
    (GO:0004697)
  • Endothelial tube morphogenesis
    (GO:0061154)
  • Golgi apparatus
    (GO:0005794)
  • Intracellular signal transduction
    (GO:0035556)
  • Metal ion binding
    (GO:0046872)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Peptidyl-serine phosphorylation
    (GO:0018105)
  • Peptidyl-threonine phosphorylation
    (GO:0018107)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna biosynthetic process
    (GO:2000573)
  • Positive regulation of endothelial cell chemotaxis
    (GO:2001028)
  • Positive regulation of endothelial cell chemotaxis by vegf-activated vascular endothelial growth factor receptor signaling pathway
    (GO:0038033)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast growth factor receptor signaling pathway
    (GO:0045743)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of intracellular signal transduction
    (GO:1902533)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of t cell receptor signaling pathway
    (GO:0050862)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030949)
  • Protein autophosphorylation
    (GO:0046777)
  • Protein binding
    (GO:0005515)
  • Protein kinase activity
    (GO:0004672)
  • Protein kinase c binding
    (GO:0005080)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine kinase activity
    (GO:0106310)
  • Regulation of t cell apoptotic process
    (GO:0070232)
  • Sphingolipid biosynthetic process
    (GO:0030148)
  • T cell receptor signaling pathway
    (GO:0050852)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)

Other Information

Genular Protein ID: 2304706259

Symbol: KPCD2_HUMAN

Name: Serine/threonine-protein kinase D2

UniProtKB Accession Codes:

Q9BZL6 B4DTS2 M0QZW1 M0R2R2 Q8NCK8 Q8TB08 Q9P0T6 Q9Y3X8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CPTAC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 9 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 6 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 2 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11062248

Title: Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase d family of serine threonine kinases.

PubMed ID: 11062248

DOI: 10.1074/jbc.m008719200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12058027

Title: Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor.

PubMed ID: 12058027

DOI: 10.1074/jbc.m200934200

PubMed ID: 15604256

Title: Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells.

PubMed ID: 15604256

DOI: 10.1158/0008-5472.can-04-0981

PubMed ID: 14743217

Title: Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.

PubMed ID: 14743217

DOI: 10.1038/ncb1090

PubMed ID: 17077180

Title: Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells.

PubMed ID: 17077180

DOI: 10.1093/intimm/dxl108

PubMed ID: 16928771

Title: Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB.

PubMed ID: 16928771

DOI: 10.1152/ajpcell.00308.2006

PubMed ID: 17962809

Title: Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.

PubMed ID: 17962809

DOI: 10.1038/sj.emboj.7601891

PubMed ID: 17951978

Title: Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation.

PubMed ID: 17951978

DOI: 10.1254/jphs.fp0070858

PubMed ID: 18076381

Title: Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.

PubMed ID: 18076381

DOI: 10.1042/bj20071334

PubMed ID: 18262756

Title: Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells.

PubMed ID: 18262756

DOI: 10.1016/j.cellsig.2008.01.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19192391

Title: PKD2 interacts with Lck and regulates NFAT activity in T cells.

PubMed ID: 19192391

DOI: 10.5483/bmbrep.2009.42.1.035

PubMed ID: 19001381

Title: Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis.

PubMed ID: 19001381

DOI: 10.1074/jbc.m807546200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23503467

Title: A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.

PubMed ID: 23503467

DOI: 10.1038/onc.2013.43

PubMed ID: 28428613

Title: Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

PubMed ID: 28428613

DOI: 10.1038/s41598-017-00800-w

PubMed ID: 18836451

Title: Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self.

PubMed ID: 18836451

DOI: 10.1038/ni.1660

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 878
  • Mass: 96722
  • Checksum: 8BAB45E8F99D23E7
  • Sequence:
    • MATAPSYPAG LPGSPGPGSP PPPGGLELQS PPPLLPQIPA PGSGVSFHIQ IGLTREFVLL 
PAASELAHVK QLACSIVDQK FPECGFYGLY DKILLFKHDP TSANLLQLVR SSGDIQEGDL 
VEVVLSASAT FEDFQIRPHA LTVHSYRAPA FCDHCGEMLF GLVRQGLKCD GCGLNYHKRC 
AFSIPNNCSG ARKRRLSSTS LASGHSVRLG TSESLPCTAE ELSRSTTELL PRRPPSSSSS 
SSASSYTGRP IELDKMLLSK VKVPHTFLIH SYTRPTVCQA CKKLLKGLFR QGLQCKDCKF 
NCHKRCATRV PNDCLGEALI NGDVPMEEAT DFSEADKSAL MDESEDSGVI PGSHSENALH 
ASEEEEGEGG KAQSSLGYIP LMRVVQSVRH TTRKSSTTLR EGWVVHYSNK DTLRKRHYWR 
LDCKCITLFQ NNTTNRYYKE IPLSEILTVE SAQNFSLVPP GTNPHCFEIV TANATYFVGE 
MPGGTPGGPS GQGAEAARGW ETAIRQALMP VILQDAPSAP GHAPHRQASL SISVSNSQIQ 
ENVDIATVYQ IFPDEVLGSG QFGVVYGGKH RKTGRDVAVK VIDKLRFPTK QESQLRNEVA 
ILQSLRHPGI VNLECMFETP EKVFVVMEKL HGDMLEMILS SEKGRLPERL TKFLITQILV 
ALRHLHFKNI VHCDLKPENV LLASADPFPQ VKLCDFGFAR IIGEKSFRRS VVGTPAYLAP 
EVLLNQGYNR SLDMWSVGVI MYVSLSGTFP FNEDEDINDQ IQNAAFMYPA SPWSHISAGA 
IDLINNLLQV KMRKRYSVDK SLSHPWLQEY QTWLDLRELE GKMGERYITH ESDDARWEQF 
AAEHPLPGSG LPTDRDLGGA CPPQDHDMQG LAERISVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.