Details for: LETMD1

Gene ID: 25875

Symbol: LETMD1

Ensembl ID: ENSG00000050426

Description: LETM1 domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.39
    Marker Score: 48,045
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.34
    Marker Score: 969
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.34
    Marker Score: 2,371
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.31
    Marker Score: 1,646
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.3
    Marker Score: 1,875
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.29
    Marker Score: 679
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.29
    Marker Score: 16,973
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.26
    Marker Score: 2,071
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.25
    Marker Score: 834
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.23
    Marker Score: 2,923
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.22
    Marker Score: 392
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.22
    Marker Score: 7,925
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.2
    Marker Score: 1,213
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.19
    Marker Score: 62,903
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1,831
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.18
    Marker Score: 2,408
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.18
    Marker Score: 396
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.18
    Marker Score: 647
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42,649
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.15
    Marker Score: 672
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.15
    Marker Score: 13,393
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.15
    Marker Score: 24,521
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.14
    Marker Score: 329
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.14
    Marker Score: 7,260
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.13
    Marker Score: 4,457
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.13
    Marker Score: 4,877
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.12
    Marker Score: 4,678
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10,590
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.11
    Marker Score: 1,845
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.1
    Marker Score: 2,996
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9,438
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.1
    Marker Score: 1,162
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.09
    Marker Score: 67,004
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.09
    Marker Score: 381
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.08
    Marker Score: 2,892
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.08
    Marker Score: 253
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10,105
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.07
    Marker Score: 1,916
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.07
    Marker Score: 2,239
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1,132
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.06
    Marker Score: 2,499
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.06
    Marker Score: 1,559
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.06
    Marker Score: 2,068
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.05
    Marker Score: 4,493
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.04
    Marker Score: 7,764
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.03
    Marker Score: 498
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.01
    Marker Score: 287
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.01
    Marker Score: 3,737
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.01
    Marker Score: 4,094
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1
    Marker Score: 350
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,623
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,845
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.99
    Marker Score: 1,113
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.98
    Marker Score: 481
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.98
    Marker Score: 9,938
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,379
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Marker Score: 2,230
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.98
    Marker Score: 848
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.98
    Marker Score: 2,218
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.97
    Marker Score: 617
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.97
    Marker Score: 1,255
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.97
    Marker Score: 657
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.97
    Marker Score: 1,043
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.97
    Marker Score: 698
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.96
    Marker Score: 2,033
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.96
    Marker Score: 9,942
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.96
    Marker Score: 392
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.96
    Marker Score: 1,026
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.96
    Marker Score: 1,285
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.95
    Marker Score: 1,027
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.95
    Marker Score: 3,679
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.95
    Marker Score: 354
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.95
    Marker Score: 591
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.95
    Marker Score: 356
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.95
    Marker Score: 1,071
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.94
    Marker Score: 185
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.94
    Marker Score: 2,564
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1,334
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,387
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.93
    Marker Score: 9,369
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.93
    Marker Score: 985
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.93
    Marker Score: 4,453
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.92
    Marker Score: 1,419
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.92
    Marker Score: 3,767
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.91
    Marker Score: 2,301
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.91
    Marker Score: 860
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.91
    Marker Score: 1,100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.91
    Marker Score: 1,542
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,717
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.9
    Marker Score: 451
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.9
    Marker Score: 656
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9
    Marker Score: 215
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,130
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.89
    Marker Score: 261
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.89
    Marker Score: 833
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.89
    Marker Score: 17,652
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,440

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The LETMD1 gene exhibits a high degree of tissue specificity, with significant expression in hematopoietic stem cells, luminal epithelial cells of the mammary gland, and primordial germ cells. The protein encoded by this gene, LTMD1_HUMAN, has been implicated in several cellular processes, including: 1. **Mitochondrial function:** LETMD1 is involved in the regulation of mitochondrial inner and outer membrane dynamics, as well as mitochondrial organization. 2. **Molecular adaptor activity:** The LETMD1 protein exhibits molecular adaptor activity, allowing it to interact with various signaling pathways and regulate cellular responses. 3. **Regulation of inflammatory response:** LETMD1 has been shown to regulate the inflammatory response, suggesting its potential role in immune modulation. 4. **Phagocytosis regulation:** The protein encoded by LETMD1 is involved in the regulation of phagocytosis, highlighting its potential role in immune cell function. **Pathways and Functions:** The LETMD1 gene is involved in several cellular pathways, including: 1. **Mitochondrial inner membrane:** LETMD1 regulates the dynamics of the mitochondrial inner membrane, which is essential for energy production and cellular homeostasis. 2. **Mitochondrial outer membrane:** LETMD1 also regulates the dynamics of the mitochondrial outer membrane, which plays a crucial role in mitochondrial function and cellular homeostasis. 3. **Mitochondrion organization:** The LETMD1 protein is involved in the organization of mitochondria, which is essential for maintaining cellular homeostasis and energy production. 4. **Nucleolus and nucleoplasm:** LETMD1 has been implicated in the regulation of nucleolus and nucleoplasm, highlighting its potential role in gene expression and cellular regulation. 5. **Positive regulation of cold-induced thermogenesis:** The protein encoded by LETMD1 regulates cold-induced thermogenesis, a process essential for maintaining cellular homeostasis in response to cold stress. **Clinical Significance:** The LETMD1 gene has significant implications for various diseases, including: 1. **Cancer:** Alterations in LETMD1 expression have been implicated in cervical cancer, highlighting its potential role as a proto-oncogene. 2. **Immune disorders:** LETMD1 has been shown to regulate the inflammatory response, suggesting its potential role in immune disorders, such as autoimmune diseases. 3. **Metabolic disorders:** The protein encoded by LETMD1 regulates cold-induced thermogenesis, highlighting its potential role in metabolic disorders, such as obesity and type 2 diabetes. In conclusion, the LETMD1 gene is a multifaceted regulator of cellular processes, including mitochondrial function, regulation of inflammatory response, and phagocytosis. Its implications for various diseases, including cancer, immune disorders, and metabolic disorders, highlight the need for further research into the role of this gene in human disease.

Genular Protein ID: 648084067

Symbol: LTMD1_HUMAN

Name: Cervical cancer 1 proto-oncogene protein p40

UniProtKB Accession Codes:

Q6P1Q0 A6NER7 B3KXK7 Q6X2E4 Q6X2E5 Q7L2G9 Q7L690 Q8WXW6 Q96PK7 Q9BY59 Q9Y3X3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12879013

Title: Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization.

PubMed ID: 12879013

DOI: 10.1038/sj.onc.1206624

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18045496

Title: HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis.

PubMed ID: 18045496

DOI: 10.1186/1471-2121-8-50

PubMed ID: 17943721

Title: HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization.

PubMed ID: 17943721

DOI: 10.1002/ijc.23146

PubMed ID: 31980577

Title: LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-kappaB Activation in Macrophages.

PubMed ID: 31980577

DOI: 10.4049/jimmunol.1900551

Sequence Information:

  • Length: 360
  • Mass: 41790
  • Checksum: EC50BEFB0E4A6DF5
  • Sequence:
    • MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK ADVKNLMSYV 
VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA KKARRIKTNM WKHNIKFHQL 
PYREMEHLRQ FRQDVTKCLF LGIISIPPFA NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL 
DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS 
NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA 
QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR

Genular Protein ID: 153977462

Symbol: F8W1Z2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W1Z2

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 236
  • Mass: 27195
  • Checksum: 5CB16E73EBA86D96
  • Sequence:
    • MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK ADVKNLMSYV 
VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA KKARRIKTNM WKHNIKFHQL 
PYREMEHLRQ KALSRAMLLT SYLPPPLLRH RLKTHTTVIH QLDKALAKLG IGQLTAQEVK 
SACYLRGLNS THIGEDRCRT WLGEWLQISC SLKEAELSLL LHNVVLLSTN YLGTRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.