Details for: RNF19A

Gene ID: 25897

Symbol: RNF19A

Ensembl ID: ENSG00000034677

Description: ring finger protein 19A, RBR E3 ubiquitin protein ligase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.67
    Marker Score: 56,987
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.26
    Marker Score: 1,743
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.18
    Marker Score: 6,122
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.15
    Marker Score: 1,256
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.11
    Marker Score: 3,102
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.07
    Marker Score: 1,234
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.07
    Marker Score: 1,360
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.02
    Marker Score: 45,067
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.97
    Marker Score: 1,132
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.96
    Marker Score: 74,441
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.96
    Marker Score: 607
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.95
    Marker Score: 6,937
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.94
    Marker Score: 1,680
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.86
    Marker Score: 14,288
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.85
    Marker Score: 2,554
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.85
    Marker Score: 896
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.84
    Marker Score: 687
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.83
    Marker Score: 1,385
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.82
    Marker Score: 761
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.81
    Marker Score: 36,071
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.78
    Marker Score: 1,234
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.76
    Marker Score: 65,025
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.76
    Marker Score: 17,412
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.75
    Marker Score: 980
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.72
    Marker Score: 741
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.72
    Marker Score: 496
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.7
    Marker Score: 1,820
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7
    Marker Score: 104,376
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.7
    Marker Score: 1,682
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.69
    Marker Score: 1,462
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.69
    Marker Score: 624
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.68
    Marker Score: 1,398
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.68
    Marker Score: 2,439
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.67
    Marker Score: 2,241
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.65
    Marker Score: 6,361
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.64
    Marker Score: 4,146
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.64
    Marker Score: 2,037
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.62
    Marker Score: 1,279
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.62
    Marker Score: 3,561
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.61
    Marker Score: 693
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.6
    Marker Score: 807
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13,713
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.59
    Marker Score: 2,247
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.56
    Marker Score: 16,106
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.56
    Marker Score: 1,886
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.55
    Marker Score: 24,880
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.55
    Marker Score: 1,571
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.55
    Marker Score: 1,053
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.54
    Marker Score: 23,098
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.54
    Marker Score: 14,527
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.54
    Marker Score: 1,659
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.52
    Marker Score: 846
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.52
    Marker Score: 5,398
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.52
    Marker Score: 545
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.51
    Marker Score: 6,154
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.5
    Marker Score: 1,477
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.5
    Marker Score: 1,403
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5
    Marker Score: 438
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.5
    Marker Score: 1,807
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.49
    Marker Score: 357
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1,551
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.49
    Marker Score: 8,822
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.48
    Marker Score: 14,092
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.48
    Marker Score: 1,329
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.48
    Marker Score: 6,134
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.47
    Marker Score: 364
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.46
    Marker Score: 1,147
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.46
    Marker Score: 880
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.45
    Marker Score: 743
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.43
    Marker Score: 1,205
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.43
    Marker Score: 705
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.43
    Marker Score: 7,500
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.43
    Marker Score: 1,343
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.42
    Marker Score: 449
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.42
    Marker Score: 502
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.42
    Marker Score: 1,542
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.42
    Marker Score: 2,727
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.42
    Marker Score: 326
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.42
    Marker Score: 884
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,182
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.41
    Marker Score: 423
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.41
    Marker Score: 306
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.4
    Marker Score: 569
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4
    Marker Score: 48,630
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.4
    Marker Score: 1,283
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.39
    Marker Score: 1,325
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.39
    Marker Score: 3,268
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.39
    Marker Score: 1,994
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.39
    Marker Score: 1,595
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.38
    Marker Score: 1,457
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.37
    Marker Score: 475
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.37
    Marker Score: 557
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.36
    Marker Score: 898
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.36
    Marker Score: 717
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.36
    Marker Score: 298
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.36
    Marker Score: 2,227
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.35
    Marker Score: 1,578
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.34
    Marker Score: 1,350
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.34
    Marker Score: 487
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.34
    Marker Score: 467

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF19A is a member of the ring finger protein family, characterized by its unique RING domain, which confers ubiquitin ligase activity. This enzyme is predominantly expressed in cells of the immune system, including CD8+ T cells, alpha-beta memory T cells, and exhausted T cells, suggesting its critical role in regulating T cell function. Additionally, RNF19A is also found in astrocytes of the cerebral cortex, suggesting a potential role in neural function and synaptic transmission. **Pathways and Functions:** RNF19A's ubiquitin ligase activity is pivotal in regulating protein degradation and modulating synaptic transmission. The enzyme is involved in the ubiquitination and proteasome degradation of proteins, which is essential for maintaining protein homeostasis and regulating cellular processes. Furthermore, RNF19A has been implicated in the regulation of synaptic transmission, modulating the activity of glutamate receptors and GABAergic cortical interneurons. RNF19A's involvement in the adaptive immune system is also noteworthy. The enzyme is expressed in CD8+ T cells and alpha-beta memory T cells, suggesting its role in T cell activation, proliferation, and differentiation. RNF19A's ubiquitin ligase activity may regulate the degradation of proteins involved in T cell signaling, thereby modulating immune responses. **Clinical Significance:** RNF19A's involvement in immune regulation and synaptic transmission has significant clinical implications. Dysregulation of RNF19A's ubiquitin ligase activity may contribute to various diseases, including autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. Furthermore, RNF19A's role in regulating synaptic transmission may be relevant to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In addition, RNF19A's expression in astrocytes of the cerebral cortex suggests a potential link between immune system dysfunction and neurological disorders. Further research is needed to elucidate the relationship between RNF19A and these diseases, as well as to explore its therapeutic potential. **Conclusion:** RNF19A is a multifaceted enzyme with far-reaching implications for our understanding of immune regulation and synaptic transmission. Its ubiquitin ligase activity plays a critical role in regulating protein degradation and modulating cellular processes, including T cell function and synaptic transmission. Further research is needed to fully elucidate RNF19A's functions and its clinical significance, but its unique expression pattern and involvement in various cellular processes make it an exciting area of study in the field of immunology and neuroscience.

Genular Protein ID: 3173227645

Symbol: RN19A_HUMAN

Name: E3 ubiquitin-protein ligase RNF19A

UniProtKB Accession Codes:

Q9NV58 A3KCU9 Q52LG1 Q9H5H9 Q9H8M8 Q9UFG0 Q9UFX6 Q9Y4Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 24 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11237715

Title: A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.

PubMed ID: 11237715

DOI: 10.1006/bbrc.2001.4414

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10976766

Title: A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

PubMed ID: 10976766

DOI: 10.1023/a:1007177623283

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12145308

Title: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.

PubMed ID: 12145308

DOI: 10.1074/jbc.m206559200

PubMed ID: 12750386

Title: Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.

PubMed ID: 12750386

DOI: 10.1074/jbc.m302763200

PubMed ID: 15456787

Title: Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.

PubMed ID: 15456787

DOI: 10.1074/jbc.m406683200

PubMed ID: 16513638

Title: Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.

PubMed ID: 16513638

DOI: 10.1074/jbc.m513552200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 838
  • Mass: 90696
  • Checksum: 00A7DED5023FDC06
  • Sequence:
    • MQEQEIGFIS KYNEGLCVNT DPVSILTSIL DMSLHRQMGS DRDLQSSASS VSLPSVKKAP 
KKRRISIGSL FRRKKDNKRK SRELNGGVDG IASIESIHSE MCTDKNSIFS TNTSSDNGLT 
SISKQIGDFI ECPLCLLRHS KDRFPDIMTC HHRSCVDCLR QYLRIEISES RVNISCPECT 
ERFNPHDIRL ILSDDVLMEK YEEFMLRRWL VADPDCRWCP APDCGYAVIA FGCASCPKLT 
CGREGCGTEF CYHCKQIWHP NQTCDAARQE RAQSLRLRTI RSSSISYSQE SGAAADDIKP 
CPRCAAYIIK MNDGSCNHMT CAVCGCEFCW LCMKEISDLH YLSPSGCTFW GKKPWSRKKK 
ILWQLGTLVG APVGIALIAG IAIPAMIIGI PVYVGRKIHN RYEGKDVSKH KRNLAIAGGV 
TLSVIVSPVV AAVTVGIGVP IMLAYVYGVV PISLCRSGGC GVSAGNGKGV RIEFDDENDI 
NVGGTNTAVD TTSVAEARHN PSIGEGSVGG LTGSLSASGS HMDRIGAIRD NLSETASTMA 
LAGASITGSL SGSAMVNCFN RLEVQADVQK ERYSLSGESG TVSLGTVSDN ASTKAMAGSI 
LNSYIPLDKE GNSMEVQVDI ESKPSKFRHN SGSSSVDDGS ATRSHAGGSS SGLPEGKSSA 
TKWSKEATAG KKSKSGKLRK KGNMKINETR EDMDAQLLEQ QSTNSSEFEA PSLSDSMPSV 
ADSHSSHFSE FSCSDLESMK TSCSHGSSDY HTRFATVNIL PEVENDRLEN SPHQCSISVV 
TQTASCSEVS QLNHIAEEHG NNGIKPNVDL YFGDALKETN NNHSHQTMEL KVAIQTEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.