RCHY1 | ENSG00000163743 | NCBI 25898

Details for: RCHY1

Gene ID: 25898

Symbol: RCHY1

Ensembl ID: ENSG00000163743

Description: ring finger and CHY zinc finger domain containing 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Dna damage bypass
(R-HSA-73893)
Dna repair
(R-HSA-73894)
Immune system
(R-HSA-168256)
Translesion synthesis by polh
(R-HSA-110320)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Error-free translesion synthesis
(GO:0070987)
Intracellular membrane-bounded organelle
(GO:0043231)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein ubiquitination
(GO:0031398)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein ubiquitination
(GO:0016567)
Rescue of stalled ribosome
(GO:0072344)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

RING finger and CHY zinc finger domain-containing protein 1

Genular Protein ID: 403771837

Symbol: ZN363_HUMAN

Name: RING finger and CHY zinc finger domain-containing protein 1

UniProtKB Accession Codes:

Q96PM5 B3KRG3 C7E541 C7E542 C7E543 D3YRV2 E7EMC8 E7ETW5 J3KPI0 Q2KN33 Q59GN7 Q86X26 Q96PR5

Database IDs:

Citations:

PubMed ID: 19483087

Title: Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains.

PubMed ID: 19483087

DOI: 10.1074/jbc.m109.024232

PubMed ID: 20452352

Title: A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma.

PubMed ID: 20452352

DOI: 10.1016/j.febslet.2010.04.075

PubMed ID: 20357911

Title: Identification of Pirh2D, an additional novel isoform of Pirh2 ubiquitin ligase.

PubMed ID: 20357911

DOI: 10.4255/mcpharmacol.10.04

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14701804

Title: Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome.

PubMed ID: 14701804

DOI: 10.1074/jbc.m312712200

PubMed ID: 15781263

Title: A new human gene hNTKL-BP1 interacts with hPirh2.

PubMed ID: 15781263

DOI: 10.1016/j.bbrc.2005.02.156

PubMed ID: 16914734

Title: Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer.

PubMed ID: 16914734

DOI: 10.1128/mcb.00147-06

PubMed ID: 17950244

Title: PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53.

PubMed ID: 17950244

DOI: 10.1016/j.bbrc.2007.10.003

PubMed ID: 18006823

Title: Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

PubMed ID: 18006823

DOI: 10.1158/0008-5472.can-07-2033

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 17721809

Title: Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA.

PubMed ID: 17721809

DOI: 10.1007/s11010-007-9586-3

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21994467

Title: Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination.

PubMed ID: 21994467

DOI: 10.1158/1541-7786.mcr-11-0157

PubMed ID: 21791603

Title: Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis.

PubMed ID: 21791603

DOI: 10.1128/mcb.05808-11

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33909987

Title: Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.

PubMed ID: 33909987

DOI: 10.1016/j.molcel.2021.03.004

PubMed ID: 19043414

Title: Molecular basis of Pirh2-mediated p53 ubiquitylation.

PubMed ID: 19043414

DOI: 10.1038/nsmb.1521

Sequence Information:

Length: 261
Mass: 30110
Checksum: AC03786F6B42A03D
Sequence:

MAATAREDGA SGQERGQRGC EHYDRGCLLK APCCDKLYTC RLCHDNNEDH QLDRFKVKEV 
QCINCEKIQH AQQTCEECST LFGEYYCDIC HLFDKDKKQY HCENCGICRI GPKEDFFHCL 
KCNLCLAMNL QGRHKCIENV SRQNCPICLE DIHTSRVVAH VLPCGHLLHR TCYEEMLKEG 
YRCPLCMHSA LDMTRYWRQL DDEVAQTPMP SEYQNMTVDI LCNDCNGRST VQFHILGMKC 
KICESYNTAQ AGGRRISLDQ Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RCHY1

Associated with

Other Information

Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. PubMed ID: 19483087

A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. PubMed ID: 20452352

Identification of Pirh2D, an additional novel isoform of Pirh2 ubiquitin ligase. PubMed ID: 20357911

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome. PubMed ID: 14701804

A new human gene hNTKL-BP1 interacts with hPirh2. PubMed ID: 15781263

Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. PubMed ID: 16914734

PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. PubMed ID: 17950244

Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. PubMed ID: 18006823

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. PubMed ID: 17721809

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Pirh2, a ubiquitin E3 ligase, inhibits p73 transcriptional activity by promoting its ubiquitination. PubMed ID: 21994467

Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. PubMed ID: 21791603

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. PubMed ID: 33909987

Molecular basis of Pirh2-mediated p53 ubiquitylation. PubMed ID: 19043414