Details for: TMEM158

Gene ID: 25907

Symbol: TMEM158

Ensembl ID: ENSG00000249992

Description: transmembrane protein 158

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.34
    Marker Score: 3,357
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.62
    Marker Score: 1,628
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.32
    Marker Score: 2,689
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.21
    Marker Score: 13,645
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.2
    Marker Score: 269
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.13
    Marker Score: 1,364
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.11
    Marker Score: 9,530
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,045
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1,014
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15,078
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,334
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1,752
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.88
    Marker Score: 559
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.86
    Marker Score: 327
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.84
    Marker Score: 1,089
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.79
    Marker Score: 7,913
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.78
    Marker Score: 3,168
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,858
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 398
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.65
    Marker Score: 22,102
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.58
    Marker Score: 1,470
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 385
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 356
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 589
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.54
    Marker Score: 743
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 222
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.46
    Marker Score: 134
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.46
    Marker Score: 1,532
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 437
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.44
    Marker Score: 232
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.44
    Marker Score: 26,845
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.44
    Marker Score: 459
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.42
    Marker Score: 242
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.42
    Marker Score: 6,210
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.41
    Marker Score: 154
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.41
    Marker Score: 770
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.4
    Marker Score: 428
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.36
    Marker Score: 982
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.36
    Marker Score: 122
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.36
    Marker Score: 442
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.34
    Marker Score: 173
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.32
    Marker Score: 315
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 138
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.29
    Marker Score: 250
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.29
    Marker Score: 1,129
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.29
    Marker Score: 409
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.28
    Marker Score: 2,124
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.26
    Marker Score: 66
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.25
    Marker Score: 89
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 578
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.25
    Marker Score: 1,026
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.24
    Marker Score: 424
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.24
    Marker Score: 133
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.24
    Marker Score: 579
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.24
    Marker Score: 2,430
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.23
    Marker Score: 533
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.23
    Marker Score: 4,069
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.23
    Marker Score: 99
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.23
    Marker Score: 1,481
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.23
    Marker Score: 92
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.22
    Marker Score: 163
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.21
    Marker Score: 245
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.21
    Marker Score: 8,063
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.2
    Marker Score: 126
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2
    Marker Score: 354
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.2
    Marker Score: 1,848

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM158 belongs to the transmembrane protein family, characterized by its ability to span the cell membrane and interact with various signaling pathways. Its expression is widespread, with notable presence in cells of the immune system, such as mononuclear phagocytes and innate lymphoid cells. TMEM158 exhibits a unique expression pattern, with significant expression in cells from the respiratory tract, gastrointestinal tract, and central nervous system. The protein's structure, with seven transmembrane domains, suggests a potential role in cell-cell communication and signaling. **Pathways and Functions:** TMEM158 is implicated in several signaling pathways, including membrane and peptide binding. The protein's interaction with these pathways suggests a role in regulating cell growth, differentiation, and survival. Specifically, TMEM158 has been shown to interact with the G-protein coupled receptor (GPCR) signaling pathway, which plays a crucial role in modulating immune responses and cellular homeostasis. Additionally, TMEM158's expression in cells of the central nervous system suggests a potential role in regulating neural function and behavior. **Clinical Significance:** The clinical significance of TMEM158 remains largely unknown, but its expression in various tissues and cell types suggests potential implications in several diseases. For example, alterations in TMEM158 expression have been linked to respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Additionally, TMEM158's role in the central nervous system may be relevant to the pathophysiology of neurological disorders, such as Alzheimer's disease and schizophrenia. Furthermore, TMEM158's interaction with the GPCR signaling pathway suggests a potential role in modulating immune responses and inflammation. This could have significant implications for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Further research is needed to fully elucidate the clinical significance of TMEM158 and its potential therapeutic applications. **Conclusion:** In conclusion, TMEM158 is a transmembrane protein with far-reaching immunological and cellular significance. Its widespread expression in various cell types and tissues suggests a complex role in regulating cell growth, differentiation, and survival. Further research is needed to fully elucidate the functional and clinical significance of TMEM158, but its potential implications in respiratory and neurological diseases make it an exciting area of investigation.

Genular Protein ID: 1216019773

Symbol: TM158_HUMAN

Name: Transmembrane protein 158

UniProtKB Accession Codes:

Q8WZ71 Q6PFW5 Q9Y4M1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11822868

Title: Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.

PubMed ID: 11822868

DOI: 10.1006/excr.2001.5434

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 300
  • Mass: 30404
  • Checksum: A555CC499B7FE0DC
  • Sequence:
    • MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL LASAAPGPPE 
RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL LLFSTNAHGR AFFAAAFHRV 
GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR GRRTGRLRPA AAPSAAAATA GAPTALPAYP 
AAEPPGPLWL QGEPLHFCCL DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA 
LIWPVPIIAG FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.