Details for: POT1
Associated with
Other Information
Genular Protein ID: 2137025161
Symbol: POTE1_HUMAN
Name: Protection of telomeres protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11349150
Title: Pot1, the putative telomere end-binding protein in fission yeast and humans.
PubMed ID: 11349150
PubMed ID: 12391173
Title: Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.
PubMed ID: 12391173
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12781132
Title: Human POT1 facilitates telomere elongation by telomerase.
PubMed ID: 12781132
PubMed ID: 12768206
Title: POT1 as a terminal transducer of TRF1 telomere length control.
PubMed ID: 12768206
DOI: 10.1038/nature01688
PubMed ID: 14715659
Title: DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites.
PubMed ID: 14715659
PubMed ID: 15231715
Title: POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
PubMed ID: 15231715
DOI: 10.1101/gad.1215404
PubMed ID: 15316005
Title: TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
PubMed ID: 15316005
PubMed ID: 15383534
Title: Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
PubMed ID: 15383534
PubMed ID: 16166375
Title: Shelterin: the protein complex that shapes and safeguards human telomeres.
PubMed ID: 16166375
DOI: 10.1101/gad.1346005
PubMed ID: 17237768
Title: The POT1-TPP1 telomere complex is a telomerase processivity factor.
PubMed ID: 17237768
DOI: 10.1038/nature05454
PubMed ID: 19179534
Title: A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.
PubMed ID: 19179534
PubMed ID: 20231318
Title: Functional interaction between telomere protein TPP1 and telomerase.
PubMed ID: 20231318
DOI: 10.1101/gad.1881810
PubMed ID: 24686849
Title: POT1 loss-of-function variants predispose to familial melanoma.
PubMed ID: 24686849
DOI: 10.1038/ng.2947
PubMed ID: 27013236
Title: A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus.
PubMed ID: 27013236
PubMed ID: 25482530
Title: Germline mutations in shelterin complex genes are associated with familial glioma.
PubMed ID: 25482530
DOI: 10.1093/jnci/dju384
PubMed ID: 35420632
Title: Telomere dysfunction implicates POT1 in patients with idiopathic pulmonary fibrosis.
PubMed ID: 35420632
DOI: 10.1084/jem.20211681
PubMed ID: 15558049
Title: Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
PubMed ID: 15558049
DOI: 10.1038/nsmb867
PubMed ID: 24686846
Title: Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.
PubMed ID: 24686846
DOI: 10.1038/ng.2941
PubMed ID: 30586141
Title: Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma.
PubMed ID: 30586141
PubMed ID: 37140166
Title: Familial Clonal Hematopoiesis in a Long Telomere Syndrome.
PubMed ID: 37140166
Sequence Information:
- Length: 634
- Mass: 71442
- Checksum: 123A12CABE708C91
- Sequence:
MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDYCSVVTIV DQTNVKLTCL LFSGNYEALP IIYKNGDIVR FHRLKIQVYK KETQGITSSG FASLTFEGTL GAPIIPRTSS KYFNFTTEDH KMVEALRVWA STHMSPSWTL LKLCDVQPMQ YFDLTCQLLG KAEVDGASFL LKVWDGTRTP FPSWRVLIQD LVLEGDLSHI HRLQNLTIDI LVYDNHVHVA RSLKVGSFLR IYSLHTKLQS MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN QHSDVICQSE PDDSFPSSGS VSLYEVERCQ QLSATILTDH QYLERTPLCA ILKQKAPQQY RIRAKLRSYK PRRLFQSVKL HCPKCHLLQE VPHEGDLDII FQDGATKTPD VKLQNTSLYD SKIWTTKNQK GRKVAVHFVK NNGILPLSNE CLLLIEGGTL SEICKLSNKF NSVIPVRSGH EDLELLDLSA PFLIQGTIHH YGCKQCSSLR SIQNLNSLVD KTSWIPSSVA EALGIVPLQY VFVMTFTLDD GTGVLEAYLM DSDKFFQIPA SEVLMDDDLQ KSVDMIMDMF CPPGIKIDAY PWLECFIKSY NVTNGTDNQI CYQIFDTTVA EDVI
Genular Protein ID: 3630853612
Symbol: A8MTK3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 12853948
Sequence Information:
- Length: 503
- Mass: 56817
- Checksum: 2CF6B188449D8AE3
- Sequence:
MVEALRVWAS THMSPSWTLL KLCDVQPMQY FDLTCQLLGK AEVDGASFLL KVWDGTRTPF PSWRVLIQDL VLEGDLSHIH RLQNLTIDIL VYDNHVHVAR SLKVGSFLRI YSLHTKLQSM NSENQTMLSL EFHLHGGTSY GRGIRVLPES NSDVDQLKKD LESANLTANQ HSDVICQSEP DDSFPSSGSV SLYEVERCQQ LSATILTDHQ YLERTPLCAI LKQKAPQQYR IRAKLRSYKP RRLFQSVKLH CPKCHLLQEV PHEGDLDIIF QDGATKTPDV KLQNTSLYDS KIWTTKNQKG RKVAVHFVKN NGILPLSNEC LLLIEGGTLS EICKLSNKFN SVIPVRSGHE DLELLDLSAP FLIQGTIHHY GCKQCSSLRS IQNLNSLVDK TSWIPSSVAE ALGIVPLQYV FVMTFTLDDG TGVLEAYLMD SDKFFQIPAS EVLMDDDLQK SVDMIMDMFC PPGIKIDAYP WLECFIKSYN VTNGTDNQIC YQIFDTTVAE DVI
Genular Protein ID: 3021899164
Symbol: Q5MJ33_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12391173
Title: Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.
PubMed ID: 12391173
PubMed ID: 12853948
Sequence Information:
- Length: 45
- Mass: 4923
- Checksum: 841205B2DC134228
- Sequence:
MSLVPATNYI YTPLNQLKGG TIVNVYGVVK FFKPPYLSKG TDSSI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.