Details for: GEMIN5

Gene ID: 25929

Symbol: GEMIN5

Ensembl ID: ENSG00000082516

Description: gem nuclear organelle associated protein 5

Associated with

Other Information

Genular Protein ID: 3411633303

Symbol: GEMI5_HUMAN

Name: Gem-associated protein 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11714716

Title: Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins.

PubMed ID: 11714716

DOI: 10.1074/jbc.m109448200

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16857593

Title: The Gemin5 protein of the SMN complex identifies snRNAs.

PubMed ID: 16857593

DOI: 10.1016/j.molcel.2006.05.036

PubMed ID: 17178713

Title: A comprehensive interaction map of the human survival of motor neuron (SMN) complex.

PubMed ID: 17178713

DOI: 10.1074/jbc.m608528200

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19377484

Title: Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains.

PubMed ID: 19377484

DOI: 10.1038/nsmb.1584

PubMed ID: 19750007

Title: Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.

PubMed ID: 19750007

DOI: 10.1371/journal.pone.0007030

PubMed ID: 20513430

Title: Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis.

PubMed ID: 20513430

DOI: 10.1016/j.molcel.2010.03.014

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25911097

Title: Gemin5 binds to the survival motor neuron mRNA to regulate SMN expression.

PubMed ID: 25911097

DOI: 10.1074/jbc.m115.646257

PubMed ID: 27507887

Title: The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation.

PubMed ID: 27507887

DOI: 10.1093/nar/gkw702

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27834343

Title: Structural basis for specific recognition of pre-snRNA by Gemin5.

PubMed ID: 27834343

DOI: 10.1038/cr.2016.133

PubMed ID: 27881600

Title: Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.

PubMed ID: 27881600

DOI: 10.1101/gad.288340.116

PubMed ID: 27881601

Title: Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5.

PubMed ID: 27881601

DOI: 10.1101/gad.291377.116

PubMed ID: 33963192

Title: Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.

PubMed ID: 33963192

DOI: 10.1038/s41467-021-22627-w

Sequence Information:

  • Length: 1508
  • Mass: 168589
  • Checksum: EA5293F395BBF14E
  • Sequence:
  • MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG TPPFRVIGEL 
    VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISTLHWSPR 
    VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID 
    ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC 
    YLATGSKDQT IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV 
    SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ LLLSTSMDRD 
    VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG DGMIRVWNTL SIKNNYDVKN 
    FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP 
    PVPPMSLGGE GDRPSLALYS CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT 
    EISWKADGKI MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM 
    ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH HDGRLVSASY 
    DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS GADDFCVHKW LTSMQDHSRP 
    PQGKKSIELE KKRLSQPKAK PKKKKKPTLR TPVKLESIDG NEEESMKENS GPVENGVSDQ 
    EGEEQAREPE LPCGLAPAVS REPVICTPVS SGFEKSKVTI NNKVILLKKE PPKEKPETLI 
    KKRKARSLLP LSTSLDHRSK EELHQDCLVL ATAKHSRELN EDVSADVEER FHLGLFTDRA 
    TLYRMIDIEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDNLV AMAPAAGYHV 
    WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLKS NHFYREAIAI AKARLRPEDP 
    VLKDLYLSWG TVLERDGHYA VAAKCYLGAT CAYDAAKVLA KKGDAASLRT AAELAAIVGE 
    DELSASLALR CAQELLLANN WVGAQEALQL HESLQGQRLV FCLLELLSRH LEEKQLSEGK 
    SSSSYHTWNT GTEGPFVERV TAVWKSIFSL DTPEQYQEAF QKLQNIKYPS ATNNTPAKQL 
    LLHICHDLTL AVLSQQMASW DEAVQALLRA VVRSYDSGSF TIMQEVYSAF LPDGCDHLRD 
    KLGDHQSPAT PAFKSLEAFF LYGRLYEFWW SLSRPCPNSS VWVRAGHRTL SVEPSQQLDT 
    ASTEETDPET SQPEPNRPSE LDLRLTEEGE RMLSTFKELF SEKHASLQNS QRTVAEVQET 
    LAEMIRQHQK SQLCKSTANG PDKNEPEVEA EQPLCSSQSQ CKEEKNEPLS LPELTKRLTE 
    ANQRMAKFPE SIKAWPFPDV LECCLVLLLI RSHFPGCLAQ EMQQQAQELL QKYGNTKTYR 
    RHCQTFCM

Genular Protein ID: 3147531278

Symbol: B7ZLC9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1507
  • Mass: 168432
  • Checksum: E41812F7CBAE2526
  • Sequence:
  • MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG TPPFRVIGEL 
    VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISTLHWSPR 
    VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID 
    ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEETS EAEITNGNAV AQAPVTKGCY 
    LATGSKDQTI RIWSCSRGRG VMILKLPFLK RRGGGIDPTV KERLWLTLHW PSNQPTQLVS 
    SCFGGELLQW DLTQSWRRKY TLFSASSEGQ NHSRIVFNLC PLQTEDDKQL LLSTSMDRDV 
    KCWDIATLEC SWTLPSLGGF AYSLAFSSVD IGSLAIGVGD GMIRVWNTLS IKNNYDVKNF 
    WQGVKSKVTA LCWHPTKEGC LAFGTDDGKV GLYDTYSNKP PQISSTYHKK TVYTLAWGPP 
    VPPMSLGGEG DRPSLALYSC GGEGIVLQHN PWKLSGEAFD INKLIRDTNS IKYKLPVHTE 
    ISWKADGKIM ALGNEDGSIE IFQIPNLKLI CTIQQHHKLV NTISWHHEHG SQPELSYLMA 
    SGSNNAVIYV HNLKTVIESS PESPVTITEP YRTLSGHTAK ITSVAWSPHH DGRLVSASYD 
    GTAQVWDALR EEPLCNFRGH QGRLLCVAWS PLDPDCIYSG ADDFCVHKWL TSMQDHSRPP 
    QGKKSIELEK KRLSQPKAKP KKKKKPTLRT PVKLESIDGN EEESMKENSG PVENGVSDQE 
    GEEQAREPEL PCGLAPAVSR EPVICTPVSS GFEKSKVTIN NKVILLKKEP PKEKPETLIK 
    KRKARSLLPL STSLDHRSKE ELHQDCLVLA TAKHSRELNE DVSADVEERF HLGLFTDRAT 
    LYRMIDIEGK GHLENGHPEL FHQLMLWKGD LKGVLQTAAE RGELTDNLVA MAPAAGYHVW 
    LWAVEAFAKQ LCFQDQYVKA ASHLLSIHKV YEAVELLKSN HFYREAIAIA KARLRPEDPV 
    LKDLYLSWGT VLERDGHYAV AAKCYLGATC AYDAAKVLAK KGDAASLRTA AELAAIVGED 
    ELSASLALRC AQELLLANNW VGAQEALQLH ESLQGQRLVF CLLELLSRHL EEKQLSEGKS 
    SSSYHTWNTG TEGPFVERVT AVWKSIFSLD TPEQYQEAFQ KLQNIKYPSA TNNTPAKQLL 
    LHICHDLTLA VLSQQMASWD EAVQALLRAV VRSYDSGSFT IMQEVYSAFL PDGCDHLRDK 
    LGDHQSPATP AFKSLEAFFL YGRLYEFWWS LSRPCPNSSV WVRAGHRTLS VEPSQQLDTA 
    STEETDPETS QPEPNRPSEL DLRLTEEGER MLSTFKELFS EKHASLQNSQ RTVAEVQETL 
    AEMIRQHQKS QLCKSTANGP DKNEPEVEAE QPLCSSQSQC KEEKNEPLSL PELTKRLTEA 
    NQRMAKFPES IKAWPFPDVL ECCLVLLLIR SHFPGCLAQE MQQQAQELLQ KYGNTKTYRR 
    HCQTFCM

Genular Protein ID: 1547828253

Symbol: Q58EZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 746
  • Mass: 82929
  • Checksum: 40FB6E0DF0C454DE
  • Sequence:
  • MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG TPPFRVIGEL 
    VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISTLHWSPR 
    VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID 
    ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC 
    YLATGSKDQT IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV 
    SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ LLLSTSMDRD 
    VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG DGMIRVWNTL SIKNNYDVKN 
    FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP 
    PVPPMSLGGE GDRPSLALYS CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT 
    EISWKADGKI MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM 
    ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH HDGRLVSASY 
    DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS GADDFCVHKW LTSMQDHSRP 
    PQGKKSIELE KKRLSQPKAK PKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.