Details for: PTPN23

Gene ID: 25930

Symbol: PTPN23

Ensembl ID: ENSG00000076201

Description: protein tyrosine phosphatase non-receptor type 23

Associated with

Other Information

Genular Protein ID: 2797730101

Symbol: PTN23_HUMAN

Name: Tyrosine-protein phosphatase non-receptor type 23

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11095967

Title: HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3.

PubMed ID: 11095967

DOI: 10.1006/bbrc.2000.3870

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18434552

Title: The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis.

PubMed ID: 18434552

DOI: 10.1073/pnas.0707601105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20393563

Title: Functional genomic screen for modulators of ciliogenesis and cilium length.

PubMed ID: 20393563

DOI: 10.1038/nature08895

PubMed ID: 21179510

Title: Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.

PubMed ID: 21179510

DOI: 10.1371/journal.pone.0014339

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21757351

Title: UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.

PubMed ID: 21757351

DOI: 10.1016/j.cub.2011.06.028

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 21889351

Title: The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.

PubMed ID: 21889351

DOI: 10.1016/j.str.2011.07.016

PubMed ID: 27839950

Title: Structural basis for selective interaction between the ESCRT regulator HD-PTP and UBAP1.

PubMed ID: 27839950

DOI: 10.1016/j.str.2016.10.006

PubMed ID: 25558065

Title: Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.

PubMed ID: 25558065

DOI: 10.1016/j.celrep.2014.12.015

PubMed ID: 27848944

Title: Clinical exome sequencing: results from 2819 samples reflecting 1000 families.

PubMed ID: 27848944

DOI: 10.1038/ejhg.2016.146

PubMed ID: 29090338

Title: Mutations of PTPN23 in developmental and epileptic encephalopathy.

PubMed ID: 29090338

DOI: 10.1007/s00439-017-1850-3

PubMed ID: 29899372

Title: Developmental epileptic encephalopathy with hypomyelination and brain atrophy associated with PTPN23 variants affecting the assembly of UsnRNPs.

PubMed ID: 29899372

DOI: 10.1038/s41431-018-0179-2

PubMed ID: 31395947

Title: Phenotype and mutation expansion of the PTPN23 associated disorder characterized by neurodevelopmental delay and structural brain abnormalities.

PubMed ID: 31395947

DOI: 10.1038/s41431-019-0487-1

Sequence Information:

  • Length: 1636
  • Mass: 178974
  • Checksum: 536BDDF9D3DC95C0
  • Sequence:
  • MEAVPRMPMI WLDLKEAGDF HFQPAVKKFV LKNYGENPEA YNEELKKLEL LRQNAVRVPR 
    DFEGCSVLRK YLGQLHYLQS RVPMGSGQEA AVPVTWTEIF SGKSVAHEDI KYEQACILYN 
    LGALHSMLGA MDKRVSEEGM KVSCTHFQCA AGAFAYLREH FPQAYSVDMS RQILTLNVNL 
    MLGQAQECLL EKSMLDNRKS FLVARISAQV VDYYKEACRA LENPDTASLL GRIQKDWKKL 
    VQMKIYYFAA VAHLHMGKQA EEQQKFGERV AYFQSALDKL NEAIKLAKGQ PDTVQDALRF 
    TMDVIGGKYN SAKKDNDFIY HEAVPALDTL QPVKGAPLVK PLPVNPTDPA VTGPDIFAKL 
    VPMAAHEASS LYSEEKAKLL REMMAKIEDK NEVLDQFMDS MQLDPETVDN LDAYSHIPPQ 
    LMEKCAALSV RPDTVRNLVQ SMQVLSGVFT DVEASLKDIR DLLEEDELLE QKFQEAVGQA 
    GAISITSKAE LAEVRREWAK YMEVHEKASF TNSELHRAMN LHVGNLRLLS GPLDQVRAAL 
    PTPALSPEDK AVLQNLKRIL AKVQEMRDQR VSLEQQLREL IQKDDITASL VTTDHSEMKK 
    LFEEQLKKYD QLKVYLEQNL AAQDRVLCAL TEANVQYAAV RRVLSDLDQK WNSTLQTLVA 
    SYEAYEDLMK KSQEGRDFYA DLESKVAALL ERTQSTCQAR EAARQQLLDR ELKKKPPPRP 
    TAPKPLLPRR EESEAVEAGD PPEELRSLPP DMVAGPRLPD TFLGSATPLH FPPSPFPSST 
    GPGPHYLSGP LPPGTYSGPT QLIQPRAPGP HAMPVAPGPA LYPAPAYTPE LGLVPRSSPQ 
    HGVVSSPYVG VGPAPPVAGL PSAPPPQFSG PELAMAVRPA TTTVDSIQAP IPSHTAPRPN 
    PTPAPPPPCF PVPPPQPLPT PYTYPAGAKQ PIPAQHHFSS GIPAGFPAPR IGPQPQPHPQ 
    PHPSQAFGPQ PPQQPLPLQH PHLFPPQAPG LLPPQSPYPY APQPGVLGQP PPPLHTQLYP 
    GPAQDPLPAH SGALPFPSPG PPQPPHPPLA YGPAPSTRPM GPQAAPLTIR GPSSAGQSTP 
    SPHLVPSPAP SPGPGPVPPR PPAAEPPPCL RRGAAAADLL SSSPESQHGG TQSPGGGQPL 
    LQPTKVDAAE GRRPQALRLI ERDPYEHPER LRQLQQELEA FRGQLGDVGA LDTVWRELQD 
    AQEHDARGRS IAIARCYSLK NRHQDVMPYD SNRVVLRSGK DDYINASCVE GLSPYCPPLV 
    ATQAPLPGTA ADFWLMVHEQ KVSVIVMLVS EAEMEKQKVA RYFPTERGQP MVHGALSLAL 
    SSVRSTETHV ERVLSLQFRD QSLKRSLVHL HFPTWPELGL PDSPSNLLRF IQEVHAHYLH 
    QRPLHTPIIV HCSSGVGRTG AFALLYAAVQ EVEAGNGIPE LPQLVRRMRQ QRKHMLQEKL 
    HLRFCYEAVV RHVEQVLQRH GVPPPCKPLA SASISQKNHL PQDSQDLVLG GDVPISSIQA 
    TIAKLSIRPP GGLESPVASL PGPAEPPGLP PASLPESTPI PSSSPPPLSS PLPEAPQPKE 
    EPPVPEAPSS GPPSSSLELL ASLTPEAFSL DSSLRGKQRM SKHNFLQAHN GQGLRATRPS 
    DDPLSLLDPL WTLNKT

Genular Protein ID: 3599291214

Symbol: B4DST5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1510
  • Mass: 164567
  • Checksum: 9FF204F75DEBA060
  • Sequence:
  • MLGAMDKRVS EEGMKVSCTH FQCAAGAFAY LREHFPQAYS VDMSRQILTL NVNLMLGQAQ 
    ECLLEKSMLD NRKSFLVARI SAQVVDYYKE ACRALENPDT ASLLGRIQKD WKKLVQMKIY 
    YFAAVAHLHM GKQAEEQQKF GERVAYFQSA LDKLNEAIKL AKGQPDTVQD ALRFTMDVIG 
    GKYNSAKKDN DFIYHEAVPA LDTLQPVKGA PLVKPLPVNP TDPAVTGPDI FAKLVPMAAH 
    EASSLYSEEK AKLLREMMAK IEDKNEVLDQ FMDSMQLDPE TVDNLDAYSH IPPQLMEKCA 
    ALSVRPDTVR NLVQSMQVLS GVFTDVEASL KDIRDLLEED ELLEQKFQEA VGQAGAISIT 
    SKAELAEVRR EWAKYMEVHE KASFTNSELH RAMNLHVGNL RLLSGPLDQV RAALPTPALS 
    PEDKAVLQNL KRILAKVQEM RDQRVSLEQQ LRELIQKDDI TASLVTTDHS EMKKLFEEQL 
    KKYDQLKVYL EQNLAAQDRV LCALTEANVQ YAAVRRVLSD LDQKWNSTLQ TLVASYEAYE 
    DLMKKSQEGR DFYADLESKV AALLERTQST CQAREAARQQ LLDRELKKKP PPRPTAPKPL 
    LPRREESEAV EAGDPPEELR SLPPDMVAGP RLPDTFLGSA TPLHFPPSPF PSSTGPGPHY 
    LSGPLPPGTY SGPTQLIQPR APGPHAMPVA PGPALYPAPA YTPELGLVPR SSPQHGVVSS 
    PYVGVGPAPP VAGLPSAPPP QFSGPELAMA VRPATTTVDS IQAPIPSHTA PRPNPTPAPP 
    PPCFPVPPPQ PLPTPYTYPA GAKQPIPAQH HFSSGIPAGF PAPRIGPQPQ PHPQPHPSQA 
    FGPQPPQQPL PLQHPHLFPP QAPGLLPPQS PYPYAPQPGV LGQPPPPLHT QLYPGPAQDP 
    LPAHSGALPF PSPGPPQPPH PPLAYGPAPS TRPMGPQAAP LTIRGPSSAG QSTPSPHLVP 
    SPAPSPGPGP VPPRPPAAEP PPCLRRGAAA ADLLSSSPES QHGGTQSPGG GQPLLQPTKV 
    DAAEGRRPQA LRLIERDPYE HPERLRQLQQ ELEAFRGQLG DVGALDTVWR ELQDAQEHDA 
    RGRSIAIARC YSLKNRHQDV MPYDSNRVVL RSGKDDYINA SCVEGLSPYC PPLVATQAPL 
    PGTAADFWLM VHEQKVSVIV MLVSEAEMEK QKVARYFPTE RGQPMVHGAL SLALSSVRST 
    ETHVERVLSL QFRDQSLKRS LVHLHFPTWP ELGLPDSPSN LLRFIQEVHA HYLHQRPLHT 
    PIIVHCSSGV GRTGAFALLY AAVQEVEAGN GIPELPQLVR RMRQQRKHML QEKLHLRFCY 
    EAVVRHVEQV LQRHGVPPPC KPLASASISQ KNHLPQDSQD LVLGGDVPIS SIQATIAKLS 
    IRPPGGLESP VASLPGPAEP PGLPPASLPE STPIPSSSPP PLSSPLPEAP QPKEEPPVPE 
    APSSGPPSSS LELLASLTPE AFSLDSSLRG KQRMSKHNFL QAHNGQGLRA TRPSDDPLSL 
    LDPLWTLNKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.