Details for: SAMHD1

Gene ID: 25939

Symbol: SAMHD1

Ensembl ID: ENSG00000101347

Description: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

Associated with

Other Information

Genular Protein ID: 1277055728

Symbol: SAMH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y3Z3 B4E2A5 E1P5V2 Q5JXG8 Q8N491 Q9H004 Q9H005 Q9H3U9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 92 PDBsum 66 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11064105

Title: Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells.

PubMed ID: 11064105

DOI: 10.1016/s0165-2478(00)00276-5

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18546154

Title: Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts.

PubMed ID: 18546154

DOI: 10.1002/pmic.200700954

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20842748

Title: Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutieres syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.

PubMed ID: 20842748

DOI: 10.1002/humu.21357

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21613998

Title: SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.

PubMed ID: 21613998

DOI: 10.1038/nature10117

PubMed ID: 21720370

Title: Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.

PubMed ID: 21720370

DOI: 10.1038/nature10195

PubMed ID: 23092512

Title: Identification and characterization of naturally occurring splice variants of SAMHD1.

PubMed ID: 23092512

DOI: 10.1186/1742-4690-9-86

PubMed ID: 23602554

Title: Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

PubMed ID: 23602554

DOI: 10.1016/j.celrep.2013.03.017

PubMed ID: 24035396

Title: Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1.

PubMed ID: 24035396

DOI: 10.1016/j.celrep.2013.08.019

PubMed ID: 23601106

Title: The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.

PubMed ID: 23601106

DOI: 10.1016/j.chom.2013.03.005

PubMed ID: 23364794

Title: Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.

PubMed ID: 23364794

DOI: 10.1074/jbc.m112.431148

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23858451

Title: The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells.

PubMed ID: 23858451

DOI: 10.1073/pnas.1312033110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25038827

Title: The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.

PubMed ID: 25038827

DOI: 10.1038/nm.3626

PubMed ID: 26101257

Title: SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity.

PubMed ID: 26101257

DOI: 10.1093/nar/gkv633

PubMed ID: 27477283

Title: Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1.

PubMed ID: 27477283

DOI: 10.1016/j.celrep.2016.07.002

PubMed ID: 28834754

Title: SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination.

PubMed ID: 28834754

DOI: 10.1016/j.celrep.2017.08.008

PubMed ID: 28229507

Title: A SAMHD1 mutation associated with Aicardi-Goutieres Syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.

PubMed ID: 28229507

DOI: 10.1002/humu.23201

PubMed ID: 28871089

Title: CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.

PubMed ID: 28871089

DOI: 10.1038/s41564-017-0019-0

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29610582

Title: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.

PubMed ID: 29610582

DOI: 10.1186/s13100-018-0116-5

PubMed ID: 29670289

Title: SAMHD1 acts at stalled replication forks to prevent interferon induction.

PubMed ID: 29670289

DOI: 10.1038/s41586-018-0050-1

PubMed ID: 29379009

Title: The SAM domain of mouse SAMHD1 is critical for its activation and regulation.

PubMed ID: 29379009

DOI: 10.1038/s41467-017-02783-8

PubMed ID: 31291580

Title: Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication.

PubMed ID: 31291580

DOI: 10.1016/j.celrep.2019.04.020

PubMed ID: 31548682

Title: Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.

PubMed ID: 31548682

DOI: 10.1038/s41564-019-0557-8

PubMed ID: 22056990

Title: HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.

PubMed ID: 22056990

DOI: 10.1038/nature10623

PubMed ID: 24217394

Title: Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase.

PubMed ID: 24217394

DOI: 10.1038/ncomms3722

PubMed ID: 24141705

Title: Mechanism of allosteric activation of SAMHD1 by dGTP.

PubMed ID: 24141705

DOI: 10.1038/nsmb.2692

PubMed ID: 25288794

Title: Structural basis of allosteric activation of sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.

PubMed ID: 25288794

DOI: 10.1074/jbc.m114.591958

PubMed ID: 24336198

Title: Structural basis of lentiviral subversion of a cellular protein degradation pathway.

PubMed ID: 24336198

DOI: 10.1038/nature12815

PubMed ID: 25267621

Title: Structural basis of cellular dNTP regulation by SAMHD1.

PubMed ID: 25267621

DOI: 10.1073/pnas.1412289111

PubMed ID: 25760601

Title: The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.

PubMed ID: 25760601

DOI: 10.1107/s1399004714027527

PubMed ID: 26294762

Title: Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592.

PubMed ID: 26294762

DOI: 10.1074/jbc.m115.677435

PubMed ID: 26431200

Title: Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.

PubMed ID: 26431200

DOI: 10.1371/journal.ppat.1005194

PubMed ID: 19525956

Title: Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response.

PubMed ID: 19525956

DOI: 10.1038/ng.373

PubMed ID: 20131292

Title: Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome.

PubMed ID: 20131292

DOI: 10.1002/art.27367

PubMed ID: 21204240

Title: Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus.

PubMed ID: 21204240

DOI: 10.1002/ajmg.a.33778

PubMed ID: 24183309

Title: Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.

PubMed ID: 24183309

DOI: 10.1016/s1474-4422(13)70258-8

Sequence Information:

  • Length: 626
  • Mass: 72201
  • Checksum: 559CB6BB029E6558
  • Sequence:
    • MQRADSEQPS KRPRCDDSPR TPSNTPSAEA DWSPGLELHP DYKTWGPEQV CSFLRRGGFE 
EPVLLKNIRE NEITGALLPC LDESRFENLG VSSLGERKKL LSYIQRLVQI HVDTMKVIND 
PIHGHIELHP LLVRIIDTPQ FQRLRYIKQL GGGYYVFPGA SHNRFEHSLG VGYLAGCLVH 
ALGEKQPELQ ISERDVLCVQ IAGLCHDLGH GPFSHMFDGR FIPLARPEVK WTHEQGSVMM 
FEHLINSNGI KPVMEQYGLI PEEDICFIKE QIVGPLESPV EDSLWPYKGR PENKSFLYEI 
VSNKRNGIDV DKWDYFARDC HHLGIQNNFD YKRFIKFARV CEVDNELRIC ARDKEVGNLY 
DMFHTRNSLH RRAYQHKVGN IIDTMITDAF LKADDYIEIT GAGGKKYRIS TAIDDMEAYT 
KLTDNIFLEI LYSTDPKLKD AREILKQIEY RNLFKYVGET QPTGQIKIKR EDYESLPKEV 
ASAKPKVLLD VKLKAEDFIV DVINMDYGMQ EKNPIDHVSF YCKTAPNRAI RITKNQVSQL 
LPEKFAEQLI RVYCKKVDRK SLYAARQYFV QWCADRNFTK PQDGDVIAPL ITPQKKEWND 
STSVQNPTRL REASKSRVQL FKDDPM

Genular Protein ID: 2061322970

Symbol: Q59H15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H15

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 DNASU 1 EMBL 2 GO 6 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 336
  • Mass: 38229
  • Checksum: 7D3FD7D6DD441452
  • Sequence:
    • LLCRTPGVAM QRADSEQPSK RPRCDDSPRT PSNTPSAEAD WSPGLELHPD YKTWGPEQVC 
SFLRRGGFEE PVLLKNIREN EITGALLPCL DESRFENLGV SSLGERKKLL SYIQRLVQIH 
VDTMKVINDP IHGHIELHPL LVRIIDTPQF QRLRYIKQLG GGYYVFPGAS HNRFEHSLGV 
GYLAGCLVHA LGEKQPELQI SERDVLCVQI AGLCHDLGHG PFSHMFDGRF IPLARPEVKW 
THEQGSVMMF EHLINSNGIK PVMEQYGLIP EEDICFIKEQ IVGPLESPVE DSLWPYKGRP 
ENKSFLYEIV SNKRNGIDVD KWDYFARDCH HLGIQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.