SIN3A | ENSG00000169375 | NCBI 25942

Details for: SIN3A

Gene ID: 25942

Symbol: SIN3A

Ensembl ID: ENSG00000169375

Description: SIN3 transcription regulator family member A

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Disease
(R-HSA-1643685)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Epigenetic regulation of gene expression
(R-HSA-212165)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hemostasis
(R-HSA-109582)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to 5mc-dna
(R-HSA-9022538)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Pervasive developmental disorders
(R-HSA-9005895)
Post-translational protein modification
(R-HSA-597592)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Signaling by alk
(R-HSA-201556)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Stat3 nuclear events downstream of alk signaling
(R-HSA-9701898)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by runx1
(R-HSA-8878171)
Activation of innate immune response
(GO:0002218)
Cellular response to dopamine
(GO:1903351)
Cellular response to glucose stimulus
(GO:0071333)
Cerebral cortex neuron differentiation
(GO:0021895)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Dna binding
(GO:0003677)
Dna replication
(GO:0006260)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Heterochromatin formation
(GO:0031507)
Histone deacetylase complex
(GO:0000118)
In utero embryonic development
(GO:0001701)
Kinetochore
(GO:0000776)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of circadian rhythm
(GO:0042754)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of protein localization to nucleus
(GO:1900181)
Negative regulation of stem cell population maintenance
(GO:1902455)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of stem cell population maintenance
(GO:1902459)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of axon extension
(GO:0030516)
Regulation of hormone levels
(GO:0010817)
Response to methylglyoxal
(GO:0051595)
Rhythmic process
(GO:0048511)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sin3-type complex
(GO:0070822)
Transcription corepressor activity
(GO:0003714)
Transcription regulator inhibitor activity
(GO:0140416)
Transcription repressor complex
(GO:0017053)
Type i interferon-mediated signaling pathway
(GO:0060337)

Other Information

Proteins

Paired amphipathic helix protein Sin3a

Genular Protein ID: 3157348874

Symbol: SIN3A_HUMAN

Name: Paired amphipathic helix protein Sin3a

UniProtKB Accession Codes:

Q96ST3 B2RNS5 Q8N8N4 Q8NC83 Q8WV18 Q96L98 Q9UFQ1

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11259580

Title: PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.

PubMed ID: 11259580

DOI: 10.1128/mcb.21.7.2298-2311.2001

PubMed ID: 12150998

Title: Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.

PubMed ID: 12150998

DOI: 10.1016/s0092-8674(02)00810-3

PubMed ID: 11897684

Title: Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.

PubMed ID: 11897684

DOI: 10.1210/endo.143.4.8748

PubMed ID: 14525983

Title: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

PubMed ID: 14525983

DOI: 10.1074/jbc.m310021200

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 12724404

Title: Identification and characterization of three new components of the mSin3A corepressor complex.

PubMed ID: 12724404

DOI: 10.1128/mcb.23.10.3456-3467.2003

PubMed ID: 15451426

Title: Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.

PubMed ID: 15451426

DOI: 10.1016/j.bbrc.2004.08.227

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16820529

Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.

PubMed ID: 16820529

DOI: 10.1093/nar/gkl401

PubMed ID: 17963697

Title: CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.

PubMed ID: 17963697

DOI: 10.1016/j.bbrc.2007.10.090

PubMed ID: 17803295

Title: TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

PubMed ID: 17803295

DOI: 10.1021/pr0703674

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21490601

Title: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.

PubMed ID: 21490601

DOI: 10.1038/nature10066

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27399968

Title: Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.

PubMed ID: 27399968

DOI: 10.1038/ng.3619

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30267900

Title: Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome.

PubMed ID: 30267900

DOI: 10.1016/j.ejmg.2018.09.014

Sequence Information:

Length: 1273
Mass: 145175
Checksum: E6A329BE0EAD84CD
Sequence:

MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS ATGIQYSVTP 
SYQVSAMPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ SHAHPAPPVA PVQGQQQFQR 
LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI MKEFKSQSID TPGVISRVSQ LFKGHPDLIM 
GFNTFLPPGY KIEVQTNDMV NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SAQSAPAPAQ 
PAPQPPPAKV SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ 
PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT PALTEQEVYA 
QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV RNDHGGTVKK PQLNNKPQRP 
SQNGCQIRRH PTGTTPPVKK KPKLLNLKDS SMADASKHGG GTESLFFDKV RKALRSAEAY 
ENFLRCLVIF NQEVISRAEL VQLVSPFLGK FPELFNWFKN FLGYKESVHL ETYPKERATE 
GIAMEIDYAS CKRLGSSYRA LPKSYQQPKC TGRTPLCKEV LNDTWVSFPS WSEDSTFVSS 
KKTQYEEHIY RCEDERFELD VVLETNLATI RVLEAIQKKL SRLSAEEQAK FRLDNTLGGT 
SEVIHRKALQ RIYADKAADI IDGLRKNPSI AVPIVLKRLK MKEEEWREAQ RGFNKVWREQ 
NEKYYLKSLD HQGINFKQND TKVLRSKSLL NEIESIYDER QEQATEENAG VPVGPHLSLA 
YEDKQILEDA AALIIHHVKR QTGIQKEDKY KIKQIMHHFI PDLLFAQRGD LSDVEEEEEE 
EMDVDEATGA VKKHNGVGGS PPKSKLLFSN TAAQKLRGMD EVYNLFYVNN NWYIFMRLHQ 
ILCLRLLRIC SQAERQIEEE NREREWEREV LGIKRDKSDS PAIQLRLKEP MDVDVEDYYP 
AFLDMVRSLL DGNIDSSQYE DSLREMFTIH AYIAFTMDKL IQSIVRQLQH IVSDEICVQV 
TDLYLAENNN GATGGQLNTQ NSRSLLESTY QRKAEQLMSD ENCFKLMFIQ SQGQVQLTIE 
LLDTEEENSD DPVEAERWSD YVERYMNSDT TSPELREHLA QKPVFLPRNL RRIRKCQRGR 
EQQEKEGKEG NSKKTMENVD SLDKLECRFK LNSYKMVYVI KSEDYMYRRT ALLRAHQSHE 
RVSKRLHQRF QAWVDKWTKE HVPREMAAET SKWLMGEGLE GLVPCTTTCD TETLHFVSIN 
KYRVKYGTVF KAP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SIN3A

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. PubMed ID: 11259580

Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. PubMed ID: 12150998

Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription. PubMed ID: 11897684

DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. PubMed ID: 14525983

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. PubMed ID: 12670868

Identification and characterization of three new components of the mSin3A corepressor complex. PubMed ID: 12724404

Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. PubMed ID: 15451426

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. PubMed ID: 16820529

CR/periphilin is a transcriptional co-repressor involved in cell cycle progression. PubMed ID: 17963697

TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins. PubMed ID: 17803295

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. PubMed ID: 19729656

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. PubMed ID: 21490601

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. PubMed ID: 27399968

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome. PubMed ID: 30267900