NECTIN3 | ENSG00000177707 | NCBI 25945

Details for: NECTIN3

Gene ID: 25945

Symbol: NECTIN3

Ensembl ID: ENSG00000177707

Description: nectin cell adhesion molecule 3

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Nectin/necl trans heterodimerization
(R-HSA-420597)
Adherens junction
(GO:0005912)
Apical junction complex
(GO:0043296)
Axon
(GO:0030424)
Cell-cell contact zone
(GO:0044291)
Cell-cell junction
(GO:0005911)
Cell adhesion molecule binding
(GO:0050839)
Dendrite
(GO:0030425)
Establishment of protein localization to plasma membrane
(GO:0061951)
Fertilization
(GO:0009566)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Lens morphogenesis in camera-type eye
(GO:0002089)
Plasma membrane
(GO:0005886)
Postsynaptic density membrane
(GO:0098839)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein localization to cell junction
(GO:1902414)
Retina morphogenesis in camera-type eye
(GO:0060042)
Symbiont entry into host cell
(GO:0046718)

Other Information

Proteins

Nectin-3

Genular Protein ID: 2782367366

Symbol: NECT3_HUMAN

Name: Nectin-3

UniProtKB Accession Codes:

Q9NQS3 E9PFR0 Q6NVZ3 Q8NC05 Q8WVU4 Q9BVA9 Q9Y412

Database IDs:

Citations:

PubMed ID: 11024295

Title: Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin.

PubMed ID: 11024295

DOI: 10.1016/s0378-1119(00)00316-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12759359

Title: Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.

PubMed ID: 12759359

DOI: 10.1074/jbc.m304166200

PubMed ID: 16216929

Title: Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.

PubMed ID: 16216929

DOI: 10.1083/jcb.200501090

PubMed ID: 19011627

Title: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

PubMed ID: 19011627

DOI: 10.1038/ni.1674

PubMed ID: 26038560

Title: Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.

PubMed ID: 26038560

DOI: 10.1073/pnas.1500791112

PubMed ID: 27680706

Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

PubMed ID: 27680706

DOI: 10.1038/nature19799

PubMed ID: 22902367

Title: Nectin ectodomain structures reveal a canonical adhesive interface.

PubMed ID: 22902367

DOI: 10.1038/nsmb.2366

Sequence Information:

Length: 549
Mass: 61002
Checksum: 6D1104CCB4A9D731
Sequence:

MARTLRPSPL CPGGGKAQLS SASLLGAGLL LQPPTPPPLL LLLFPLLLFS RLCGALAGPI 
IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSSQ TVAVHHPQYG FSVQGEYQGR 
VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS 
LIDGGNETVA AICIAATGKP VAHIDWEGDL GEMESTTTSF PNETATIISQ YKLFPTRFAR 
GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF 
KSVWSRLDGQ WPDGLLASDN TLHFVHPLTF NYSGVYICKV TNSLGQRSDQ KVIYISDPPT 
TTTLQPTIQW HPSTADIEDL ATEPKKLPFP LSTLATIKDD TIATIIASVV GGALFIVLVS 
VLAGIFCYRR RRTFRGDYFA KNYIPPSDMQ KESQIDVLQQ DELDSYPDSV KKENKNPVNN 
LIRKDYLEEP EKTQWNNVEN LNRFERPMDY YEDLKMGMKF VSDEHYDENE DDLVSHVDGS 
VISRREWYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NECTIN3

Associated with

Other Information

Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. PubMed ID: 11024295

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains. PubMed ID: 12759359

Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. PubMed ID: 16216929

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. PubMed ID: 19011627

Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity. PubMed ID: 26038560

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. PubMed ID: 27680706

Nectin ectodomain structures reveal a canonical adhesive interface. PubMed ID: 22902367