Details for: PARS2

Gene ID: 25973

Symbol: PARS2

Ensembl ID: ENSG00000162396

Description: prolyl-tRNA synthetase 2, mitochondrial

Associated with

Other Information

Genular Protein ID: 1480792956

Symbol: SYPM_HUMAN

Name: Probable proline--tRNA ligase, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15779907

Title: Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.

PubMed ID: 15779907

DOI: 10.1021/bi047527z

PubMed ID: 25629079

Title: Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers syndrome.

PubMed ID: 25629079

DOI: 10.1002/mgg3.115

PubMed ID: 28077841

Title: PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder.

PubMed ID: 28077841

DOI: 10.1038/jhg.2016.163

PubMed ID: 28202951

Title:

PubMed ID: 28202951

DOI: 10.1038/jhg.2017.13

PubMed ID: 29410512

Title: Clinical and molecular characteristics of newly reported mitochondrial disease entity caused by biallelic PARS2 mutations.

PubMed ID: 29410512

DOI: 10.1038/s10038-017-0401-z

PubMed ID: 29915213

Title: The genotypic and phenotypic spectrum of PARS2-related infantile-onset encephalopathy.

PubMed ID: 29915213

DOI: 10.1038/s10038-018-0478-z

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

PubMed ID: 34585293

Title: Four pedigrees with aminoacyl-tRNA synthetase abnormalities.

PubMed ID: 34585293

DOI: 10.1007/s10072-021-05626-z

Sequence Information:

  • Length: 475
  • Mass: 53263
  • Checksum: E3B1B07CB6225BA2
  • Sequence:
  • MEGLLTRCRA LPALATCSRQ LSGYVPCRFH HCAPRRGRRL LLSRVFQPQN LREDRVLSLQ 
    DKSDDLTCKS QRLMLQVGLI YPASPGCYHL LPYTVRAMEK LVRVIDQEMQ AIGGQKVNMP 
    SLSPAELWQA TNRWDLMGKE LLRLRDRHGK EYCLGPTHEE AITALIASQK KLSYKQLPFL 
    LYQVTRKFRD EPRPRFGLLR GREFYMKDMY TFDSSPEAAQ QTYSLVCDAY CSLFNKLGLP 
    FVKVQADVGT IGGTVSHEFQ LPVDIGEDRL AICPRCSFSA NMETLDLSQM NCPACQGPLT 
    KTKGIEVGHT FYLGTKYSSI FNAQFTNVCG KPTLAEMGCY GLGVTRILAA AIEVLSTEDC 
    VRWPSLLAPY QACLIPPKKG SKEQAASELI GQLYDHITEA VPQLHGEVLL DDRTHLTIGN 
    RLKDANKFGY PFVIIAGKRA LEDPAHFEVW CQNTGEVAFL TKDGVMDLLT PVQTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.