Details for: MMACHC
Associated with
Other Information
Genular Protein ID: 3763954612
Symbol: MMAC_HUMAN
Name: Cyanocobalamin reductase / alkylcobalamin dealkylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18779575
Title: Decyanation of vitamin B12 by a trafficking chaperone.
PubMed ID: 18779575
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19801555
Title: A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.
PubMed ID: 19801555
PubMed ID: 19700356
Title: Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria.
PubMed ID: 19700356
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21071249
Title: Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B(1)(2) metabolism.
PubMed ID: 21071249
PubMed ID: 23415655
Title: The C-terminal domain of CblD interacts with CblC and influences intracellular cobalamin partitioning.
PubMed ID: 23415655
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23270877
Title: Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism.
PubMed ID: 23270877
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25535791
Title: Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.
PubMed ID: 25535791
PubMed ID: 26483544
Title: Structural insights into the MMACHC-MMADHC protein complex involved in vitamin B12 trafficking.
PubMed ID: 26483544
PubMed ID: 27771510
Title: Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC.
PubMed ID: 27771510
PubMed ID: 21697092
Title: Structural basis of multifunctionality in a vitamin B12-processing enzyme.
PubMed ID: 21697092
PubMed ID: 22642810
Title: Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
PubMed ID: 22642810
DOI: 10.1021/bi300150y
PubMed ID: 16311595
Title: Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type.
PubMed ID: 16311595
DOI: 10.1038/ng1683
PubMed ID: 20219402
Title: Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder.
PubMed ID: 20219402
PubMed ID: 25809485
Title: Pathogenic mutations differentially affect the catalytic activities of the human B12-processing chaperone CblC and increase futile redox cycling.
PubMed ID: 25809485
Sequence Information:
- Length: 282
- Mass: 31728
- Checksum: 3A7E6BC774CB5D17
- Sequence:
MEPKVAELKQ KIEDTLCPFG FEVYPFQVAW YNELLPPAFH LPLPGPTLAF LVLSTPAMFD RALKPFLQSC HLRMLTDPVD QCVAYHLGRV RESLPELQIE IIADYEVHPN RRPKILAQTA AHVAGAAYYY QRQDVEADPW GNQRISGVCI HPRFGGWFAI RGVVLLPGIE VPDLPPRKPH DCVPTRADRI ALLEGFNFHW RDWTYRDAVT PQERYSEEQK AYFSTPPAQR LALLGLAQPS EKPSSPSPDL PFTTPAPKKP GNPSRARSWL SPRVSPPASP GP
Genular Protein ID: 1724804648
Symbol: A0A0C4DGU2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 225
- Mass: 25331
- Checksum: D0C3014E49A1233F
- Sequence:
MFDRALKPFL QSCHLRMLTD PVDQCVAYHL GRVRESLPEL QIEIIADYEV HPNRRPKILA QTAAHVAGAA YYYQRQDVEA DPWGNQRISG VCIHPRFGGW FAIRGVVLLP GIEVPDLPPR KPHDCVPTRA DRIALLEGFN FHWRDWTYRD AVTPQERYSE EQKAYFSTPP AQRLALLGLA QPSEKPSSPS PDLPFTTPAP KKPGNPSRAR SWLSPRVSPP ASPGP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.