Details for: AOC1

Gene ID: 26

Symbol: AOC1

Ensembl ID: ENSG00000002726

Description: amine oxidase copper containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.4759
    Cell Significance Index: -7.7300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 6.2106
    Cell Significance Index: 47.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 5.0083
    Cell Significance Index: 227.0100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 5.0000
    Cell Significance Index: 50.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.9341
    Cell Significance Index: 113.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6993
    Cell Significance Index: -9.9100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.5845
    Cell Significance Index: 28.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.3801
    Cell Significance Index: 258.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1910
    Cell Significance Index: 32.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4418
    Cell Significance Index: 99.7100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3004
    Cell Significance Index: 8.0800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.2547
    Cell Significance Index: 14.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0626
    Cell Significance Index: 105.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0382
    Cell Significance Index: 22.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8987
    Cell Significance Index: 14.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8845
    Cell Significance Index: 21.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7818
    Cell Significance Index: 25.0400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.7264
    Cell Significance Index: 12.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6349
    Cell Significance Index: 120.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5780
    Cell Significance Index: 20.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4765
    Cell Significance Index: 11.9100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4425
    Cell Significance Index: 2.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0552
    Cell Significance Index: 30.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0493
    Cell Significance Index: 0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0445
    Cell Significance Index: 32.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0365
    Cell Significance Index: 1.5900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0162
    Cell Significance Index: 0.1000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0048
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.5200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0052
    Cell Significance Index: -0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0145
    Cell Significance Index: -2.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0152
    Cell Significance Index: -0.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0165
    Cell Significance Index: -3.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0188
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0196
    Cell Significance Index: -2.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0205
    Cell Significance Index: -7.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0276
    Cell Significance Index: -2.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0284
    Cell Significance Index: -8.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0294
    Cell Significance Index: -1.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0316
    Cell Significance Index: -6.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0394
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0402
    Cell Significance Index: -8.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0451
    Cell Significance Index: -6.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0479
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0510
    Cell Significance Index: -8.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0525
    Cell Significance Index: -1.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0586
    Cell Significance Index: -7.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0620
    Cell Significance Index: -0.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0646
    Cell Significance Index: -4.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0655
    Cell Significance Index: -1.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0750
    Cell Significance Index: -7.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0775
    Cell Significance Index: -8.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0782
    Cell Significance Index: -1.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0819
    Cell Significance Index: -9.6600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0820
    Cell Significance Index: -1.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0968
    Cell Significance Index: -2.8500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1066
    Cell Significance Index: -0.7500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1084
    Cell Significance Index: -1.4200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1128
    Cell Significance Index: -1.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1208
    Cell Significance Index: -7.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1210
    Cell Significance Index: -5.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1214
    Cell Significance Index: -8.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1274
    Cell Significance Index: -1.3900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1355
    Cell Significance Index: -1.1700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1422
    Cell Significance Index: -1.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1474
    Cell Significance Index: -9.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1561
    Cell Significance Index: -8.7600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1614
    Cell Significance Index: -1.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1634
    Cell Significance Index: -4.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1634
    Cell Significance Index: -1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1676
    Cell Significance Index: -4.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1867
    Cell Significance Index: -8.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1971
    Cell Significance Index: -10.2400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2002
    Cell Significance Index: -2.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2110
    Cell Significance Index: -9.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2205
    Cell Significance Index: -8.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2229
    Cell Significance Index: -7.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2231
    Cell Significance Index: -8.1900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2318
    Cell Significance Index: -1.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2403
    Cell Significance Index: -6.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2430
    Cell Significance Index: -7.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2444
    Cell Significance Index: -3.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2447
    Cell Significance Index: -8.0100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2537
    Cell Significance Index: -3.7100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2560
    Cell Significance Index: -3.0100
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.2581
    Cell Significance Index: -2.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2598
    Cell Significance Index: -5.3900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2599
    Cell Significance Index: -2.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2601
    Cell Significance Index: -9.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AOC1 is a copper-dependent enzyme, meaning that it requires copper ions to catalyze its reactions. The AOC1 protein is a homodimer, consisting of two identical subunits. It is also a membrane-bound enzyme, with a transmembrane domain that anchors it to the plasma membrane. The AOC1 protein has a specific substrate specificity, primarily targeting primary and secondary amines, such as putrescine and methylputrescine. The enzyme's activity is inhibited by amiloride, a known inhibitor of amine oxidases. **Pathways and Functions** AOC1 is involved in several cellular pathways, including: 1. **Amine Metabolism**: AOC1 plays a crucial role in the metabolism of primary and secondary amines, which are involved in various physiological processes, including neurotransmission, blood pressure regulation, and immune responses. 2. **Immune System**: AOC1 is expressed in immune cells and is involved in the regulation of immune responses, including neutrophil degranulation and the production of reactive oxygen species. 3. **Neurotransmission**: AOC1 is expressed in neurons and is involved in the regulation of neurotransmission, including the modulation of glutamate and GABA neurotransmission. 4. **Blood Pressure Regulation**: AOC1 is involved in the regulation of blood pressure, with its activity influencing the production of aldehydes and hydrogen peroxide, which have vasoconstrictive properties. 5. **Cellular Response to Stress**: AOC1 is involved in the cellular response to stress, including the regulation of reactive oxygen species production and the induction of apoptosis. **Clinical Significance** Dysregulation of AOC1 has been implicated in various diseases, including: 1. **Hypertension**: Elevated AOC1 activity has been linked to hypertension, with the enzyme's activity influencing blood pressure regulation. 2. **Neurodegenerative Diseases**: AOC1 dysregulation has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, with the enzyme's activity influencing neurotransmission and oxidative stress. 3. **Cancer**: AOC1 has been shown to be overexpressed in certain types of cancer, including colon cancer, with the enzyme's activity influencing tumor growth and metastasis. 4. **Immune System Disorders**: AOC1 dysregulation has been implicated in immune system disorders, including autoimmune diseases and immunodeficiency diseases. In conclusion, AOC1 is a critical enzyme involved in various cellular processes, including amine metabolism, immune system regulation, neurotransmission, and blood pressure regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of AOC1 in maintaining cellular homeostasis.

Genular Protein ID: 104605540

Symbol: AOC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P19801 C9J690 Q16683 Q16684 Q56II4 Q6GU42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChEBI 39 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 6 Rhea 8 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2217167

Title: Human kidney amiloride-binding protein: cDNA structure and functional expression.

PubMed ID: 2217167

DOI: 10.1073/pnas.87.19.7347

PubMed ID: 8182053

Title: The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter.

PubMed ID: 8182053

DOI: 10.1016/s0021-9258(17)36648-6

PubMed ID: 8595053

Title: cDNA sequences of variant forms of human placenta diamine oxidase.

PubMed ID: 8595053

DOI: 10.1007/bf02401856

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8144586

Title: Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.

PubMed ID: 8144586

DOI: 10.1016/s0021-9258(17)36970-3

PubMed ID: 239684

Title: Oxidation of polymines by diamine oxidase from human seminal plasma.

PubMed ID: 239684

DOI: 10.1042/bj1450373

PubMed ID: 12072962

Title: Human kidney diamine oxidase: heterologous expression, purification, and characterization.

PubMed ID: 12072962

DOI: 10.1007/s00775-001-0331-1

PubMed ID: 19764817

Title: Structure and inhibition of human diamine oxidase.

PubMed ID: 19764817

DOI: 10.1021/bi9014192

Sequence Information:

  • Length: 751
  • Mass: 85378
  • Checksum: 37114CD0D446639C
  • Sequence:
    • MPALGWAVAA ILMLQTAMAE PSPGTLPRKA GVFSDLSNQE LKAVHSFLWS KKELRLQPSS 
TTTMAKNTVF LIEMLLPKKY HVLRFLDKGE RHPVREARAV IFFGDQEHPN VTEFAVGPLP 
GPCYMRALSP RPGYQSSWAS RPISTAEYAL LYHTLQEATK PLHQFFLNTT GFSFQDCHDR 
CLAFTDVAPR GVASGQRRSW LIIQRYVEGY FLHPTGLELL VDHGSTDAGH WAVEQVWYNG 
KFYGSPEELA RKYADGEVDV VVLEDPLPGG KGHDSTEEPP LFSSHKPRGD FPSPIHVSGP 
RLVQPHGPRF RLEGNAVLYG GWSFAFRLRS SSGLQVLNVH FGGERIAYEV SVQEAVALYG 
GHTPAGMQTK YLDVGWGLGS VTHELAPGID CPETATFLDT FHYYDADDPV HYPRALCLFE 
MPTGVPLRRH FNSNFKGGFN FYAGLKGQVL VLRTTSTVYN YDYIWDFIFY PNGVMEAKMH 
ATGYVHATFY TPEGLRHGTR LHTHLIGNIH THLVHYRVDL DVAGTKNSFQ TLQMKLENIT 
NPWSPRHRVV QPTLEQTQYS WERQAAFRFK RKLPKYLLFT SPQENPWGHK RTYRLQIHSM 
ADQVLPPGWQ EEQAITWARY PLAVTKYRES ELCSSSIYHQ NDPWHPPVVF EQFLHNNENI 
ENEDLVAWVT VGFLHIPHSE DIPNTATPGN SVGFLLRPFN FFPEDPSLAS RDTVIVWPRD 
NGPNYVQRWI PEDRDCSMPP PFSYNGTYRP V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.