TKFC | ENSG00000149476 | NCBI 26007

Details for: TKFC

Gene ID: 26007

Symbol: TKFC

Ensembl ID: ENSG00000149476

Description: triokinase and FMN cyclase

Associated with

Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Disease
(R-HSA-1643685)
Fructose catabolism
(R-HSA-70350)
Fructose metabolism
(R-HSA-5652084)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Carbohydrate metabolic process
(GO:0005975)
Carbohydrate phosphorylation
(GO:0046835)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Fad-amp lyase (cyclizing) activity
(GO:0034012)
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
(GO:0061624)
Glycerol catabolic process
(GO:0019563)
Glycerone kinase activity
(GO:0004371)
Metal ion binding
(GO:0046872)
Negative regulation of mda-5 signaling pathway
(GO:0039534)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of innate immune response
(GO:0045088)
Triokinase activity
(GO:0050354)

Other Information

Proteins

Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

Genular Protein ID: 222012333

Symbol: TKFC_HUMAN

Name: Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)

UniProtKB Accession Codes:

Q3LXA3 Q2L9C1 Q53EQ9 Q9BVA7 Q9H895

Database IDs:

Citations:

PubMed ID: 16289032

Title: Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases.

PubMed ID: 16289032

DOI: 10.1016/j.bbrc.2005.10.142

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4688871

Title: Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization.

PubMed ID: 4688871

PubMed ID: 17600090

Title: Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.

PubMed ID: 17600090

DOI: 10.1073/pnas.0700544104

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24569995

Title: Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements.

PubMed ID: 24569995

DOI: 10.1074/jbc.m113.525626

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32004446

Title: Bi-allelic variants in TKFC encoding triokinase/FMN cyclase are associated with cataracts and multisystem disease.

PubMed ID: 32004446

DOI: 10.1016/j.ajhg.2020.01.005

Sequence Information:

Length: 575
Mass: 58947
Checksum: 4DB8C5326F65122C
Sequence:

MTSKKLVNSV AGCADDALAG LVACNPNLQL LQGHRVALRS DLDSLKGRVA LLSGGGSGHE 
PAHAGFIGKG MLTGVIAGAV FTSPAVGSIL AAIRAVAQAG TVGTLLIVKN YTGDRLNFGL 
AREQARAEGI PVEMVVIGDD SAFTVLKKAG RRGLCGTVLI HKVAGALAEA GVGLEEIAKQ 
VNVVAKAMGT LGVSLSSCSV PGSKPTFELS ADEVELGLGI HGEAGVRRIK MATADEIVKL 
MLDHMTNTTN ASHVPVQPGS SVVMMVNNLG GLSFLELGII ADATVRSLEG RGVKIARALV 
GTFMSALEMP GISLTLLLVD EPLLKLIDAE TTAAAWPNVA AVSITGRKRS RVAPAEPQEA 
PDSTAAGGSA SKRMALVLER VCSTLLGLEE HLNALDRAAG DGDCGTTHSR AARAIQEWLK 
EGPPPASPAQ LLSKLSVLLL EKMGGSSGAL YGLFLTAAAQ PLKAKTSLPA WSAAMDAGLE 
AMQKYGKAAP GDRTMLDSLW AAGQELQAWK SPGADLLQVL TKAVKSAEAA AEATKNMEAG 
AGRASYISSA RLEQPDPGAV AAAAILRAIL EVLQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TKFC

Associated with

Other Information

Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases. PubMed ID: 16289032

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization. PubMed ID: 4688871

Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. PubMed ID: 17600090

Initial characterization of the human central proteome. PubMed ID: 21269460

Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements. PubMed ID: 24569995

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Bi-allelic variants in TKFC encoding triokinase/FMN cyclase are associated with cataracts and multisystem disease. PubMed ID: 32004446