L3MBTL1 | ENSG00000185513 | NCBI 26013

Details for: L3MBTL1

Gene ID: 26013

Symbol: L3MBTL1

Ensembl ID: ENSG00000185513

Description: L3MBTL histone methyl-lysine binding protein 1

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through methylation
(R-HSA-6804760)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by tp53
(R-HSA-3700989)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin lock complex
(GO:0061793)
Chromatin organization
(GO:0006325)
Condensed chromosome
(GO:0000793)
Hemopoiesis
(GO:0030097)
Heterochromatin formation
(GO:0031507)
Histone binding
(GO:0042393)
Identical protein binding
(GO:0042802)
Methylated histone binding
(GO:0035064)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleosome binding
(GO:0031491)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of megakaryocyte differentiation
(GO:0045652)
Regulation of mitotic nuclear division
(GO:0007088)
Sam domain binding
(GO:0032093)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Lethal(3)malignant brain tumor-like protein 1

Genular Protein ID: 1592372461

Symbol: LMBL1_HUMAN

Name: Lethal(3)malignant brain tumor-like protein 1

UniProtKB Accession Codes:

Q9Y468 B4DRC9 E1P5W7 Q5H8Y8 Q5H8Y9 Q8IUV7 Q9H1E6 Q9H1G5 Q9UG06 Q9UJB9 Q9Y4C9

Database IDs:

Citations:

PubMed ID: 10445843

Title: A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes.

PubMed ID: 10445843

DOI: 10.1038/sj.onc.1202732

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12588862

Title: The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).

PubMed ID: 12588862

DOI: 10.1074/jbc.m300592200

PubMed ID: 15123827

Title: Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies.

PubMed ID: 15123827

DOI: 10.1073/pnas.0308195101

PubMed ID: 17540172

Title: L3MBTL1, a histone-methylation-dependent chromatin lock.

PubMed ID: 17540172

DOI: 10.1016/j.cell.2007.03.048

PubMed ID: 18408754

Title: Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1.

PubMed ID: 18408754

DOI: 10.1038/onc.2008.67

PubMed ID: 20870719

Title: Methylation of the retinoblastoma tumor suppressor by SMYD2.

PubMed ID: 20870719

DOI: 10.1074/jbc.m110.137612

PubMed ID: 22120668

Title: The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.

PubMed ID: 22120668

DOI: 10.1038/nsmb.2188

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12842041

Title: Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets.

PubMed ID: 12842041

DOI: 10.1016/s0969-2126(03)00127-8

PubMed ID: 18042461

Title: Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.

PubMed ID: 18042461

DOI: 10.1016/j.molcel.2007.10.023

PubMed ID: 18026117

Title: L3MBTL1 recognition of mono- and dimethylated histones.

PubMed ID: 18026117

DOI: 10.1038/nsmb1340

PubMed ID: 20870725

Title: The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.

PubMed ID: 20870725

DOI: 10.1074/jbc.m110.139527

Sequence Information:

Length: 840
Mass: 92297
Checksum: 70004D458897CB24
Sequence:

MHLVAGDSPG SGPHLPATAF IIPASSATLG LPSSALDVSC FPREPIHVGA PEQVAGCEPV 
SATVLPQLSA GPASSSTSTV RLLEWTEAAA PPPGGGLRFR ISEYKPLNMA GVEQPPSPEL 
RQEGVTEYED GGAPAGDGEA GPQQAEDHPQ NPPEDPNQDP PEDDSTCQCQ ACGPHQAAGP 
DLGSSNDGCP QLFQERSVIV ENSSGSTSAS ELLKPMKKRK RREYQSPSEE ESEPEAMEKQ 
EEGKDPEGQP TASTPESEEW SSSQPATGEK KECWSWESYL EEQKAITAPV SLFQDSQAVT 
HNKNGFKLGM KLEGIDPQHP SMYFILTVAE VCGYRLRLHF DGYSECHDFW VNANSPDIHP 
AGWFEKTGHK LQPPKGYKEE EFSWSQYLRS TRAQAAPKHL FVSQSHSPPP LGFQVGMKLE 
AVDRMNPSLV CVASVTDVVD SRFLVHFDNW DDTYDYWCDP SSPYIHPVGW CQKQGKPLTP 
PQDYPDPDNF CWEKYLEETG ASAVPTWAFK VRPPHSFLVN MKLEAVDRRN PALIRVASVE 
DVEDHRIKIH FDGWSHGYDF WIDADHPDIH PAGWCSKTGH PLQPPLGPRE PSSASPGGCP 
PLSYRSLPHT RTSKYSFHHR KCPTPGCDGS GHVTGKFTAH HCLSGCPLAE RNQSRLKAEL 
SDSEASARKK NLSGFSPRKK PRHHGRIGRP PKYRKIPQED FQTLTPDVVH QSLFMSALSA 
HPDRSLSVCW EQHCKLLPGV AGISASTVAK WTIDEVFGFV QTLTGCEDQA RLFKDEARIV 
RVTHVSGKTL VWTVAQLGDL VCSDHLQEGK GILETGVHSL LCSLPTHLLA KLSFASDSQY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: L3MBTL1

Associated with

Other Information

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. PubMed ID: 10445843

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9734811

The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). PubMed ID: 12588862

Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies. PubMed ID: 15123827

L3MBTL1, a histone-methylation-dependent chromatin lock. PubMed ID: 17540172

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. PubMed ID: 18408754

Methylation of the retinoblastoma tumor suppressor by SMYD2. PubMed ID: 20870719

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. PubMed ID: 22120668

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. PubMed ID: 12842041

Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. PubMed ID: 18042461

L3MBTL1 recognition of mono- and dimethylated histones. PubMed ID: 18026117

The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. PubMed ID: 20870725