OSBPL3 | ENSG00000070882 | NCBI 26031

Details for: OSBPL3

Gene ID: 26031

Symbol: OSBPL3

Ensembl ID: ENSG00000070882

Description: oxysterol binding protein like 3

Associated with

Bile acid and bile salt metabolism
(R-HSA-194068)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Bile acid biosynthetic process
(GO:0006699)
Cholesterol binding
(GO:0015485)
Cytosol
(GO:0005829)
Endoplasmic reticulum membrane
(GO:0005789)
Filopodium tip
(GO:0032433)
Membrane
(GO:0016020)
Nuclear membrane
(GO:0031965)
Perinuclear endoplasmic reticulum
(GO:0097038)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Sterol transport
(GO:0015918)
Sterol transporter activity
(GO:0015248)

Other Information

Proteins

Oxysterol-binding protein-related protein 3

Genular Protein ID: 3631822199

Symbol: OSBL3_HUMAN

Name: Oxysterol-binding protein-related protein 3

UniProtKB Accession Codes:

Q9H4L5 A4D167 A4D168 A4D169 A4D170 A4D171 A4D172 B8ZZ79 B8ZZP0 O14591 O43357 O43358 Q8N702 Q8N703 Q8N704 Q8NFH0 Q8NFH1 Q8NI12 Q8NI13 Q9BZF4 Q9UED6

Database IDs:

Citations:

PubMed ID: 11568019

Title: ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells.

PubMed ID: 11568019

DOI: 10.1182/blood.v98.7.2279

PubMed ID: 11735225

Title: A family of 12 human genes containing oxysterol-binding domains.

PubMed ID: 11735225

DOI: 10.1006/geno.2001.6663

PubMed ID: 12590732

Title: ORP3 splice variants and their expression in human tissues and hematopoietic cells.

PubMed ID: 12590732

DOI: 10.1089/104454903321112442

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11483621

Title: The OSBP-related protein family in humans.

PubMed ID: 11483621

PubMed ID: 14593528

Title: Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7.

PubMed ID: 14593528

DOI: 10.1007/s00441-003-0817-y

PubMed ID: 16143324

Title: Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.

PubMed ID: 16143324

DOI: 10.1016/j.yexcr.2005.08.003

PubMed ID: 17428193

Title: The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.

PubMed ID: 17428193

DOI: 10.1042/bj20070176

PubMed ID: 18270267

Title: The R-Ras interaction partner ORP3 regulates cell adhesion.

PubMed ID: 18270267

DOI: 10.1242/jcs.016964

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25447204

Title: OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.

PubMed ID: 25447204

DOI: 10.1016/j.yexcr.2014.10.019

Sequence Information:

Length: 887
Mass: 101224
Checksum: 12E16912BD3F2E99
Sequence:

MMSDEKNLGV SQKLVSPSRS TSSCSSKQGS RQDSWEVVEG LRGEMNYTQE PPVQKGFLLK 
KRKWPLKGWH KRFFYLDKGI LKYAKSQTDI EREKLHGCID VGLSVMSVKK SSKCIDLDTE 
EHIYHLKVKS EEVFDEWVSK LRHHRMYRQN EIAMFPHEVN HFFSGSTITD SSSGVFDSIS 
SRKRSSISKQ NLFQTGSNVS FSCGGETRVP LWLQSSEDME KCSKDLAHCH AYLVEMSQLL 
QSMDVLHRTY SAPAINAIQG GSFESPKKEK RSHRRWRSRA IGKDAKGTLQ VPKPFSGPVR 
LHSSNPNLST LDFGEEKNYS DGSETSSEFS KMQEDLCHIA HKVYFTLRSA FNIMSAEREK 
LKQLMEQDAS SSPSAQVIGL KNALSSALAQ NTDLKERLRR IHAESLLLDS PAVAKSGDNL 
AEENSRDENR ALVHQLSNES RLSITDSLSE FFDAQEVLLS PSSSENEISD DDSYVSDISD 
NLSLDNLSND LDNERQTLGP VLDSGREAKS RRRTCLPAPC PSSSNISLWN ILRNNIGKDL 
SKVAMPVELN EPLNTLQRLC EELEYSELLD KAAQIPSPLE RMVYVAAFAI SAYASSYYRA 
GSKPFNPVLG ETYECIREDK GFQFFSEQVS HHPPISACHA ESRNFVFWQD VRWKNKFWGK 
SMEIVPIGTT HVTLPVFGDH FEWNKVTSCI HNILSGQRWI EHYGEIVIKN LHDDSCYCKV 
NFIKAKYWST NAHEIEGTVF DRSGKAVHRL FGKWHESIYC GGGSSSACVW RANPMPKGYE 
QYYSFTQFAL ELNEMDPSSK SLLPPTDTRF RPDQRFLEEG NLEEAEIQKQ RIEQLQRERR 
RVLEENHVEH QPRFFRKSDD DSWVSNGTYL ELRKDLGFSK LDHPVLW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: OSBPL3

Associated with

Other Information

ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells. PubMed ID: 11568019

A family of 12 human genes containing oxysterol-binding domains. PubMed ID: 11735225

ORP3 splice variants and their expression in human tissues and hematopoietic cells. PubMed ID: 12590732

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. PubMed ID: 9734811

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The OSBP-related protein family in humans. PubMed ID: 11483621

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. PubMed ID: 14593528

Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants. PubMed ID: 16143324

The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. PubMed ID: 17428193

The R-Ras interaction partner ORP3 regulates cell adhesion. PubMed ID: 18270267

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. PubMed ID: 25447204