Details for: PPP1R16B

Gene ID: 26051

Symbol: PPP1R16B

Ensembl ID: ENSG00000101445

Description: protein phosphatase 1 regulatory subunit 16B

Associated with

  • Cell projection
    (GO:0042995)
  • Cytoplasm
    (GO:0005737)
  • Enzyme inhibitor activity
    (GO:0004857)
  • Establishment of endothelial barrier
    (GO:0061028)
  • Myosin phosphatase regulator activity
    (GO:0017020)
  • Negative regulation of peptidyl-serine dephosphorylation
    (GO:1902309)
  • Negative regulation of protein dephosphorylation
    (GO:0035308)
  • Nuclear speck
    (GO:0016607)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903589)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of protein dephosphorylation
    (GO:0035307)
  • Protein binding
    (GO:0005515)
  • Protein phosphatase regulator activity
    (GO:0019888)
  • Regulation of filopodium assembly
    (GO:0051489)
  • Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051896)
  • Regulation of protein dephosphorylation
    (GO:0035304)
  • Regulation of sprouting angiogenesis
    (GO:1903670)

Other Information

Genular Protein ID: 3490170434

Symbol: PP16B_HUMAN

Name: Protein phosphatase 1 regulatory inhibitor subunit 16B

UniProtKB Accession Codes:

Q96T49 A2RRR6 E9PFS8 O94912 Q5W9G4 Q9NQG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 9 Ensembl 2 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12055102

Title: TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells.

PubMed ID: 12055102

DOI: 10.1152/ajpcell.00442.2001

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15491607

Title: Alternative splice variants encoding unstable protein domains exist in the human brain.

PubMed ID: 15491607

DOI: 10.1016/j.jmb.2004.09.028

PubMed ID: 16263087

Title: The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation.

PubMed ID: 16263087

DOI: 10.1016/j.bbrc.2005.10.089

PubMed ID: 18586956

Title: TIMAP is a positive regulator of pulmonary endothelial barrier function.

PubMed ID: 18586956

DOI: 10.1152/ajplung.00325.2007

PubMed ID: 21907835

Title: TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS.

PubMed ID: 21907835

DOI: 10.1016/j.resp.2011.08.012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25007873

Title: TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells.

PubMed ID: 25007873

DOI: 10.1152/ajprenal.00070.2014

PubMed ID: 26497934

Title: Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex.

PubMed ID: 26497934

DOI: 10.1016/j.biocel.2015.10.021

Sequence Information:

  • Length: 567
  • Mass: 63551
  • Checksum: 8418CE26D0035CF1
  • Sequence:
    • MASHVDLLTE LQLLEKVPTL ERLRAAQKRR AQQLKKWAQY EQDLQHRKRK HERKRSTGGR 
RKKVSFEASV ALLEASLRND AEEVRYFLKN KVSPDLCNED GLTALHQCCI DNFEEIVKLL 
LSHGANVNAK DNELWTPLHA AATCGHINLV KILVQYGADL LAVNSDGNMP YDLCEDEPTL 
DVIETCMAYQ GITQEKINEM RVAPEQQMIA DIHCMIAAGQ DLDWIDAQGA TLLHIAGANG 
YLRAAELLLD HGVRVDVKDW DGWEPLHAAA FWGQMQMAEL LVSHGASLSA RTSMDEMPID 
LCEEEEFKVL LLELKHKHDV IMKSQLRHKS SLSRRTSSAG SRGKVVRRAS LSDRTNLYRK 
EYEGEAILWQ RSAAEDQRTS TYNGDIRETR TDQENKDPNP RLEKPVLLSE FPTKIPRGEL 
DMPVENGLRA PVSAYQYALA NGDVWKVHEV PDYSMAYGNP GVADATPPWS SYKEQSPQTL 
LELKRQRAAA KLLSHPFLST HLGSSMARTG ESSSEGKAPL IGGRTSPYSS NGTSVYYTVT 
SGDPPLLKFK APIEEMEEKV HGCCRIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.