Details for: LYSET

Gene ID: 26175

Symbol: LYSET

Ensembl ID: ENSG00000153485

Description: lysosomal enzyme trafficking factor

Associated with

Other Information

Genular Protein ID: 3637221146

Symbol: LYSET_HUMAN

Name: Transmembrane protein 251

UniProtKB Accession Codes:

Q8N6I4 J3KQ65 Q9Y4S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 4 GO 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 STRING 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33252156

Title: Biallelic TMEM251 variants in patients with severe skeletal dysplasia and extreme short stature.

PubMed ID: 33252156

DOI: 10.1002/humu.24139

PubMed ID: 36074822

Title: Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.

PubMed ID: 36074822

DOI: 10.1126/science.abn5637

PubMed ID: 36074821

Title: The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

PubMed ID: 36074821

DOI: 10.1126/science.abn5648

PubMed ID: 36096887

Title: GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.

PubMed ID: 36096887

DOI: 10.1038/s41467-022-33025-1

Sequence Information:

  • Length: 163
  • Mass: 18747
  • Checksum: 805D11CD73B20650
  • Sequence:
    • MPKPPDYSEL SDSLTLAVGT GRFSGPLHRA WRMMNFRQRM GWIGVGLYLL ASAAAFYYVF 
EISETYNRLA LEHIQQHPEE PLEGTTWTHS LKAQLLSLPF WVWTVIFLVP YLQMFLFLYS 
CTRADPKTVG YCIIPICLAV ICNRHQAFVK ASNQISRLQL IDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.